A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Public ClinicalTrials.gov record NCT06908226. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-Label Study to Investigate the Long-Term Safety and Efficacy of LP352 in the Treatment of Seizures in Children and Adults With Developmental and Epileptic Encephalopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This (DEEp OLE Study) is a multicentre, open-label study to investigate the long-term safety, efficacy, tolerability, and pharmacokinetics (PK) of LP352 in the treatment of seizures in children and adults with DEE who completed Study LP352-301 or LP352-302. The study consists of 3 main phases: Screening, Titration period and Maintenance period, followed by a Taper period and Follow-Up. The total duration of the study will be approximately 14 months.
Study identification
- NCT ID
- NCT06908226
- Recruitment status
- Enrolling by invitation
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 324 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 2 Years to 66 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 12, 2025 (Actual)
- Primary completion
- Nov 11, 2027 (Estimated)
- Completion
- Dec 17, 2027 (Estimated)
- Last update posted
- Oct 14, 2026
2025 – 2027
United States locations
- U.S. sites
- 21
- U.S. states
- 13
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arkansas Children's Hospital - Cardiology Clinic | Little Rock | Arkansas | 72202-3500 | — |
| University of California Los Angeles (UCLA) - David Geffen School of Medicine - Global Health Pro... | Los Angeles | California | 90095 | — |
| Stanford University - Stanford School of Medicine - Pulmonary and Cystic Fibrosis Center | Palo Alto | California | 94304-1511 | — |
| UCSF Benioff Children's Hospitals - San Francisco | San Francisco | California | 94158 | — |
| Children's Hospital Colorado - Heart Institute | Aurora | Colorado | 80045-7106 | — |
| NW FL Clinical Research Group, LLC | Gulf Breeze | Florida | 32561-4495 | — |
| University of Miami Medical Group (UMMG) | Miami | Florida | 33136-2117 | — |
| Research Institute of Orlando LLC | Orlando | Florida | 32806 | — |
| Pediatric Epilepsy & Neurology Specialists (PENS) | Tampa | Florida | 33609-4191 | — |
| University of South Florida (USF) - Tampa Campus | Tampa | Florida | 33620 | — |
| Consultants in Epilepsy & Neurology, PLLC | Boise | Idaho | 83702-5029 | — |
| University of Iowa Health Care Medical Center (University of Iowa Hospitals & Clinics) | Iowa City | Iowa | 52242-1009 | — |
| Mid-Atlantic Epilepsy and Sleep Center - Bethesda | Bethesda | Maryland | 20817-1844 | — |
| Massachusetts General Hospital (MGH) | Boston | Massachusetts | 02114 | — |
| Mayo Clinic - Children's Center - Rochester | Rochester | Minnesota | 55905-0001 | — |
| Barnabas Health - Institute of Neurology and Neurosurgery | Livingston | New Jersey | 07039-5817 | — |
| Northeast Regional Epilepsy Group - Morristown | Morristown | New Jersey | 07960-6092 | — |
| NYU Langone Health-NYU Comprehensive Epilepsy Center | New York | New York | 10016-4852 | — |
| Oregon Health & Science University - Blood Brain Barrier and Neuro-Oncology Program | Portland | Oregon | 97239-3098 | — |
| Child Neurology Consultants of Austin - Austin | Austin | Texas | 78731-3157 | — |
| The University of Texas Medical School at Houston - UT Gastroenterology | Houston | Texas | 77030-1517 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06908226, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06908226 live on ClinicalTrials.gov.