A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

ClinicalTrials.gov ID: NCT06925542

Public ClinicalTrials.gov record NCT06925542. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 8:58 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1 Dose Evaluation Study of the Safety and Preliminary Efficacy of Anti-CD19 Allogeneic CRISPR-Cas9-Engineered T Cells (CTX112) in Adult Subjects With Refractory Autoimmune Disease

Study identification

NCT ID: NCT06925542
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: CRISPR Therapeutics; Industry
Enrollment: 80 participants

Conditions and interventions

Conditions

Interventions

CTX112 Biological

Biological

Eligibility (public fields only)

Age range: 18 Years to 70 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 9, 2025
Primary completion: Dec 30, 2031
Completion: Dec 30, 2031
Last update posted: Jul 21, 2026

2025 – 2031

United States locations

U.S. sites: 7
U.S. states: 7
U.S. cities: 7

Facility	City	State	ZIP	Site status
Stanford University Medical Center	Redwood City	California	94063	Recruiting
Northwestern Medicine, Robert H. Lurie Comprehensive Cancer Center	Chicago	Illinois	63110	Recruiting
University of Iowa	Iowa City	Iowa	52242	Recruiting
Manning Family Children's Hospital of New Orleans	New Orleans	Louisiana	70118	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Washington University School of Medicine	St Louis	Missouri	63130	Recruiting
University of North Carolina TraCS Institute - CTRC	Chapel Hill	North Carolina	27599	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06925542, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 21, 2026 · Synced Jul 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06925542 live on ClinicalTrials.gov.

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