ClinicalTrials.gov record
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
ClinicalTrials.gov ID: NCT06935370
Public ClinicalTrials.gov record NCT06935370. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 2:08 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EASi-HF Reduced - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Chronic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) < 40%
Study identification
- NCT ID
- NCT06935370
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Boehringer Ingelheim
- Industry
- Enrollment
- 4,200 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- empagliflozin Drug
- vicadrostat Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 19, 2025
- Primary completion
- Feb 3, 2029
- Completion
- Feb 21, 2029
- Last update posted
- Apr 28, 2026
2025 – 2029
United States locations
- U.S. sites
- 107
- U.S. states
- 26
- U.S. cities
- 94
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alliance for Multispecialty Research, LLC | Mobile | Alabama | 36608 | Not yet recruiting |
| Drug Research and Analysis Corporation | Montgomery | Alabama | 36106 | Not yet recruiting |
| Cure Clinical Research | Beverly Hills | California | 90211 | Recruiting |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | Recruiting |
| North Coast Cardiology | Encinitas | California | 92024 | Not yet recruiting |
| Orange County Research Center | Lake Forest | California | 92630 | Not yet recruiting |
| Merced Vein and Vascular Center | Merced | California | 95340 | Recruiting |
| Radin Cardiovascular Medical Group | Newport Beach | California | 92663 | Not yet recruiting |
| Amicis Research Center - Nordhoff | Northridge | California | 91324 | Terminated |
| University of California San Diego | San Diego | California | 92103 | Not yet recruiting |
| Paradigm Clinical Research - San Diego | San Diego | California | 92108 | Not yet recruiting |
| Amicis Research Corporate | Santa Clarita | California | 91355 | Suspended |
| Care Access Research | Thousand Oaks | California | 91360 | Not yet recruiting |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | Not yet recruiting |
| Bay Area Cardiology | Brandon | Florida | 33511 | Recruiting |
| Cardiology Associates Research Co. | Daytona Beach | Florida | 32117 | Recruiting |
| Suncoast Research Associates, LLC | Doral | Florida | 33172 | Recruiting |
| Malcom Randall VA Medical Center | Gainesville | Florida | 32608 | Recruiting |
| Velocity Clinical Research-Hallandale Beach-67888 | Hallandale | Florida | 33009 | Recruiting |
| University of Florida | Jacksonville | Florida | 32209 | Recruiting |
| East Coast Institute For Research, LLC | Jacksonville | Florida | 32216 | Recruiting |
| First Coast Cardiovascular Institute | Jacksonville | Florida | 32216 | Not yet recruiting |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | Recruiting |
| University of Miami - Miller School of Medicine | Miami | Florida | 33125 | Not yet recruiting |
| Infinite Clinical Research Inc | Miami | Florida | 33133 | Recruiting |
| Inpatient Research Clinic, LLC | Miami Lakes | Florida | 33014 | Recruiting |
| Innovation Medical Research Center | Palmetto Bay | Florida | 33157 | Recruiting |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | Recruiting |
| St. Johns Center for Clinical Research | Saint Augustine | Florida | 32086 | Recruiting |
| Cardiology Partners Clinical Research Institute | Wellington | Florida | 33449 | Recruiting |
| Cozy Research LLC | Wesley Chapel | Florida | 33544 | Recruiting |
| Clinical Site Partners, LLC | Winter Park | Florida | 32789 | Recruiting |
| Atlanta Clinical Research Centers | Atlanta | Georgia | 30342 | Recruiting |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | Not yet recruiting |
| NSC Research Inc | Johns Creek | Georgia | 30024 | Recruiting |
| Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois | 60005 | Not yet recruiting |
| Illinois Masonic Hospital | Chicago | Illinois | 60657 | Not yet recruiting |
| Chicago Medical Research | Hazel Crest | Illinois | 60429 | Recruiting |
| Clinical Investigation Specialists, Inc. | Libertyville | Illinois | 60048 | Recruiting |
| AMR Park Ridge | Park Ridge | Illinois | 60068 | Recruiting |
| Springfield Clinic | Springfield | Illinois | 62703 | Recruiting |
| Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana | 46514 | Not yet recruiting |
| St. Francis Medical Group-Indiana Heart Physicians, Inc | Indianapolis | Indiana | 46237 | Not yet recruiting |
| Indiana Medical Research Institute | Merrillville | Indiana | 46410 | Not yet recruiting |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | Recruiting |
| Reid Hospital | Richmond | Indiana | 47374 | Recruiting |
| The Iowa Clinic, PC | West Des Moines | Iowa | 50266 | Recruiting |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | Not yet recruiting |
| Kansas Nephrology Research Institute, LLC | Wichita | Kansas | 67214 | Recruiting |
| Robert J Dole Veterans Affairs Medical Center | Wichita | Kansas | 67218 | Recruiting |
| West Houston Area Clinical Trial Consultants, LLC | Wichita | Kansas | 67226 | Recruiting |
| Norton Healtcare - Norton Heart and Vascular Institute | Louisville | Kentucky | 40217 | Not yet recruiting |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | Recruiting |
| Grace Research, LLC-Shreveport-64616 | Shreveport | Louisiana | 71105 | Recruiting |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | Recruiting |
| Metropolitan Cardiovascular Consultants | Beltsville | Maryland | 20705 | Not yet recruiting |
| Capitol Cardiology Associates | Lanham | Maryland | 20706 | Recruiting |
| McLaren Bay Region Medical Center | Bay City | Michigan | 48708 | Not yet recruiting |
| Cardiology and Vascular Associates - CAVA | Bloomfield Hills | Michigan | 48304 | Recruiting |
| Michigan Healthcare Professionals Pulse Cardiology | Farmington Hills | Michigan | 48334 | Not yet recruiting |
| St. John Providence Hospital | Novi | Michigan | 48374 | Not yet recruiting |
| Michigan Heart, PC | Ypsilanti | Michigan | 48197 | Not yet recruiting |
| Minneapolis VA Health Care System | Minneapolis | Minnesota | 55417 | Not yet recruiting |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | Not yet recruiting |
| Regions Hospital | Saint Paul | Minnesota | 55101 | Not yet recruiting |
| Jackson Heart Clinic, P.A. | Jackson | Mississippi | 39216 | Not yet recruiting |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | Not yet recruiting |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | Not yet recruiting |
| St. Louis Heart and Vascular, P.C. | St Louis | Missouri | 63136 | Recruiting |
| Be Well Clinical Studies | Omaha | Nebraska | 68144 | Recruiting |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | Recruiting |
| Garden State Heart Care, PC | Manalapan | New Jersey | 07726 | Not yet recruiting |
| Bassett Medical Center | Cooperstown | New York | 13326 | Not yet recruiting |
| Mount Sinai Hospital-New York-52529 | New York | New York | 10019 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| IMA Clinical Research Lenoir | Lenoir | North Carolina | 28645 | Not yet recruiting |
| Pinehurst Medical Clinic, Inc. - East | Pinehurst | North Carolina | 28374 | Not yet recruiting |
| WakeMed | Raleigh | North Carolina | 27610 | Not yet recruiting |
| Piedmont Healthcare, Inc. | Statesville | North Carolina | 28625 | Recruiting |
| Wilmington Health | Wilmington | North Carolina | 28401 | Not yet recruiting |
| VA Northeast Ohio Healthcare System | Cleveland | Ohio | 44106 | Not yet recruiting |
| K and R Research LLC | Marion | Ohio | 43302 | Recruiting |
| Cardiology Consultants of Philadelphia | Yardley | Pennsylvania | 19067 | Recruiting |
| Bon Secours Medical Group Greenville Specialty Care, LLC | Greenville | South Carolina | 29607 | Terminated |
| Monument Health | Rapid City | South Dakota | 57701 | Not yet recruiting |
| Pharmatex Research | Amarillo | Texas | 79109 | Recruiting |
| Amarillo Heart Clinical Research Institute, Incorporated | Amarillo | Texas | 79124 | Recruiting |
| NextStage Clinical Research | Beaumont | Texas | 77702-1513 | Recruiting |
| Headlands Research Brownsville | Brownsville | Texas | 78526 | Not yet recruiting |
| Texas Health Research and Education Institute | Dallas | Texas | 75231 | Recruiting |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | Recruiting |
| Helios CR Inc - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | Not yet recruiting |
| DM Clinical Research Dallas | Irving | Texas | 75061 | Recruiting |
| DCOL Center for Clinical Research | Longview | Texas | 75605 | Recruiting |
| North Texas Research Associates | McKinney | Texas | 75071 | Recruiting |
| Revival Research Institute, LLC - McKinney | McKinney | Texas | 75071 | Recruiting |
| Texas Institute Of Cardiology | McKinney | Texas | 75071 | Recruiting |
| Stryde Research | Plano | Texas | 75093 | Not yet recruiting |
| Accurate Clinical Research, Inc. | Richmond | Texas | 77469 | Recruiting |
| Baylor Scott and White Health | Temple | Texas | 76508 | Not yet recruiting |
| Northwest Heart Center | Tomball | Texas | 77375 | Recruiting |
| NextStage Clinical Research | Waco | Texas | 76712 | Recruiting |
| Virginia Heart - Falls Church | Falls Church | Virginia | 22042 | Not yet recruiting |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | Recruiting |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | Not yet recruiting |
| Carilion Clinic | Roanoke | Virginia | 24014 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 528 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06935370, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06935370 live on ClinicalTrials.gov.