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Active, not recruiting Phase 3 Interventional

A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)

ClinicalTrials.gov ID: NCT06941844

Public ClinicalTrials.gov record NCT06941844. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 22, 2026, 3:03 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Emerge

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Emerge

Study identification

NCT ID
NCT06941844
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Definium Therapeutics US, Inc.
Industry
Enrollment
149 participants

Conditions and interventions

Interventions

Other · Drug

Eligibility (public fields only)

Age range
18 Years to 74 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 14, 2025 (Actual)
Primary completion
May 20, 2026 (Actual)
Completion
Feb 2027 (Estimated)
Last update posted
Aug 28, 2026

2025 – 2027

United States locations

U.S. sites
22
U.S. states
16
U.S. cities
20
Facility City State ZIP Site status
Preferred Research Partners, Inc Little Rock Arkansas 72211 —
Kadima Neuropsychiatry Institute La Jolla California 92037 —
Psychedelic Science Institute Santa Monica California 90404 —
Mountain View Clinical Research, Inc Denver Colorado 80209 —
CNS, LLC (Jacksonville) Jacksonville Florida 32256 —
CNS, LLC (Orlando) Orlando Florida 32801 —
Charter Research Orlando Florida 32803 —
Uptown Research Institute (URI), LLC Chicago Illinois 60640 —
Sheppard Pratt Baltimore Maryland 21204 —
Adams Clinical Boston Boston Massachusetts 02116 —
Adams Clinical Watertown Massachusetts 02472 —
University of Missouri Columbia Missouri 65212 —
Cenexel HRI Berlin New Jersey 08053 —
Adams Clinical Harlem New York New York 10029 —
Columbia - New York State Psychiatric Institute New York New York 10032 —
Neuro-Behavioral Clinical Research Canton Ohio 44720 —
University of Cincinnati Cincinnati Ohio 45219 —
Adams Clinical Philadelphia Philadelphia Pennsylvania 19104 —
CNS, LLC (Memphis) Memphis Tennessee 38119 —
Austin Clinical Trial Partners Austin Texas 78737 —
Cedar Clinical Research Murray Utah 84020 —
Memory Clinic, Inc Bennington Vermont 05201 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06941844, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 28, 2026 · Synced Oct 22, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06941844 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →