A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

ClinicalTrials.gov ID: NCT06963710

Public ClinicalTrials.gov record NCT06963710. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 6:58 PM EDT

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Official title

A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

Study identification

NCT ID: NCT06963710
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Aligos Therapeutics; Industry
Enrollment: 200 participants

Conditions and interventions

Conditions

Chronic Hepatitis B Infection

Interventions

ALG-000184 Drug
TDF Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 14, 2025
Primary completion: Feb 28, 2027
Completion: Jul 31, 2028
Last update posted: Apr 30, 2026

2025 – 2028

United States locations

U.S. sites: 18
U.S. states: 8
U.S. cities: 17

Facility	City	State	ZIP	Site status
Aligos Investigational Site	Chandler	Arizona	85224	Recruiting
Aligos Investigational Site	Coronado	California	92118	Recruiting
Aligos Investigational Site	Garden Grove	California	92840	Recruiting
Aligos Investigational Site	Los Angeles	California	90033	Recruiting
Aligos Investigational Site	Palo Alto	California	94304	Recruiting
Aligos Investigational Site	Pasadena	California	91105	Recruiting
Aligos Investigational Site	Rialto	California	92377	Recruiting
Aligos Investigational Site	San Francisco	California	94117	Recruiting
Aligos Investigational Site	San Jose	California	95116	Recruiting
Aligos Investigational Site	Miami	Florida	33136	Recruiting
Aligos Investigational Site	Miami	Florida	33173	Recruiting
Aligos Investigational Site	Marrero	Louisiana	70072	Recruiting
Aligos Investigational Site	Baltimore	Maryland	21287	Recruiting
Aligos Investigational Site	Chevy Chase	Maryland	20815	Recruiting
Aligos Investigational Site	Boston	Massachusetts	02114	Recruiting
Aligos Investigational Site	Manhasset	New York	10075	Recruiting
Aligos Investigational Site	New York	New York	10016	Recruiting
Aligos Investigational Site	Durham	North Carolina	27710	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 40 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06963710, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced Jul 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06963710 live on ClinicalTrials.gov.

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