A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
Public ClinicalTrials.gov record NCT06966453. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1B/2, OPEN-LABEL, MULTICOHORT STUDY OF DISITAMAB VEDOTIN IN ADULTS WITH HER2 EXPRESSING ADVANCED BREAST CANCER
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study is to learn about the safety and effects of the study medicine (called disitamab vedotin) for the possible treatment of people with breast cancer that is hard to treat and has spread in the body (advanced cancer). This study is seeking participants who: * have breast cancer that is hard to treat and has spread in the body (advanced cancer) * have tumors that have HER2 on them * have received previous treatment for their advanced breast cancer All participants in this study will receive disitamab vedotin at the study clinic once every 2 weeks as an intravenous (IV) infusion (given directly into a vein). Participants will take the study medicine until they or their doctor decides to stop. This might be because their cancer is getting worse, the study medicine is no longer helping, they have bad side effects, or they wish to stop taking the study medicine. During this time, the participants will have study visits every 2 weeks. After the participants have stopped taking the study medicine, they will have follow-up visits about every 6 weeks unless their cancer gets worse. After that, they will have follow-up phone calls about every 12 weeks. The study team will look at the experiences of people receiving the study medicine. This will help the study team decide if the study medicine is safe and effective.
Study identification
- NCT ID
- NCT06966453
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 74 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2025 (Actual)
- Primary completion
- Oct 25, 2027 (Estimated)
- Completion
- Jan 27, 2030 (Estimated)
- Last update posted
- Sep 9, 2026
2025 – 2030
United States locations
- U.S. sites
- 136
- U.S. states
- 14
- U.S. cities
- 110
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center, PC | Daphne | Alabama | 36526 | — |
| Southern Cancer Center, PC | Foley | Alabama | 36535 | — |
| Southern Cancer Center, PC | Mobile | Alabama | 36608 | — |
| Banner Gateway Medical Center | Gilbert | Arizona | 85234 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Oncura Health - Anaheim | Anaheim | California | 92805 | — |
| City of Hope National Medical Center | Duarte | California | 91010 | — |
| Stanford Cancer Center Emeryville | Emeryville | California | 94608 | — |
| Oncura Health - Fountain Valley | Fountain Valley | California | 92708 | — |
| Oncura Health - Corporate | Glendale | California | 91204 | — |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | — |
| Oncura Health - Good Samaritan | Los Angeles | California | 90017 | — |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | — |
| Mission Community Hospital (Satellite Site) | Los Angeles | California | 91402 | — |
| Clinical and Translational Research Unit (CTRU) | Palo Alto | California | 94304 | — |
| Stanford Cancer Center | Palo Alto | California | 94304 | — |
| Stanford Women's Cancer Center | Palo Alto | California | 94304 | — |
| Stanford Cancer Center Pleasanton | Pleasanton | California | 94588 | — |
| Stanford Healthcare - Portola Valley | Portola | California | 94208 | — |
| Stanford University Cancer Center South Bay | San Jose | California | 95124 | — |
| Stanford Health Care, Investigational Drug Service | Stanford | California | 94305 | — |
| Oncura Health -Valley Presbyterian | Van Nuys | California | 91405 | — |
| Rocky Mountain Cancer Centers, LLP | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers, LLP | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers, LLP | Centennial | Colorado | 80112 | — |
| Rocky Mountain Cancer Centers, LLP | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers, LLP | Colorado Springs | Colorado | 80923 | — |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers, LLP | Englewood | Colorado | 80113 | — |
| Rocky Mountain Cancer Centers, LLP | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers, LLP | Littleton | Colorado | 80120 | — |
| Rocky Mountain Cancer Centers, LLP | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers, LLP | Longmont | Colorado | 80504 | — |
| Rocky Mountain Cancer Centers, LLP | Pueblo | Colorado | 81003 | — |
| Rocky Mountain Cancer Centers, LLP | Thornton | Colorado | 80260 | — |
| Smilow Cancer Hospital - Derby | Derby | Connecticut | 06418 | — |
| Smilow Cancer Hospital - Fairfield | Fairfield | Connecticut | 06824 | — |
| Smilow Cancer Hospital - Glastonbury | Glastonbury | Connecticut | 06033 | — |
| Smilow Cancer Hospital - Greenwich | Greenwich | Connecticut | 06830 | — |
| Smilow Cancer Hospital - Guilford | Guilford | Connecticut | 06437 | — |
| Smilow Cancer Hospital at St. Francis | Hartford | Connecticut | 06105 | — |
| Smilow Cancer Hospital - Yale New Haven Health | New Haven | Connecticut | 06510 | — |
| Yale-New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Yale University - Smilow Cancer Hospital; C/O Thomas Ferencz, RPh, BCOP | New Haven | Connecticut | 06511 | — |
| Yale School of Medicine | New Haven | Connecticut | 06520 | — |
| Smilow Cancer Hospital - North Haven | North Haven | Connecticut | 06473 | — |
| Smilow Cancer Hospital - Long Ridge | Stamford | Connecticut | 06902 | — |
| Smilow Cancer Hospital - Torrington | Torrington | Connecticut | 06790 | — |
| Smilow Cancer Hospital - Trumbull | Trumbull | Connecticut | 06611 | — |
| Smilow Cancer Hospital - Waterbury | Waterbury | Connecticut | 06708 | — |
| Smilow Cancer Hospital - Waterford | Waterford | Connecticut | 06385 | — |
| Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy | Washington D.C. | District of Columbia | 20007 | — |
| Medstar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists | Clearwater | Florida | 33761 | — |
| Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center | Coral Gables | Florida | 33146 | — |
| Sylvester Comprehensive Cancer Center - Coral Springs | Coral Springs | Florida | 33065 | — |
| University of Miami Hospital and Clinics - Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Sylvester Comprehensive Cancer Center- Doral | Doral | Florida | 33166 | — |
| Florida Cancer Specialists | Gainesville | Florida | 32605 | — |
| Sylvester Comprehensive Cancer Center - Hollywood | Hollywood | Florida | 33021 | — |
| Florida Cancer Specialists | Largo | Florida | 33770 | — |
| Florida Cancer Specialists | Lecanto | Florida | 34461 | — |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| University of Miami Hospital and Clinics | Miami | Florida | 33136 | — |
| Sylvester Comprehensive Cancer Center - Kendall | Miami | Florida | 33176 | — |
| Sylvester Comprehensive Cancer Center - Sole Mia | North Miami | Florida | 33181 | — |
| Florida Cancer Specialists | Ocala | Florida | 34474 | — |
| Florida Cancer Specialists | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists | Orlando | Florida | 32806 | — |
| Sylvester Comprehensive Cancer Center - Plantation | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33701 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists | Tallahassee | Florida | 32308 | — |
| Florida Cancer Specialists | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists | The Villages | Florida | 32159 | — |
| Florida Cancer Specialists | Trinity | Florida | 34655 | — |
| Florida Cancer Specialists | Winter Park | Florida | 32789 | — |
| Winship Cancer Institute @ Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory Clinic Investigational Drug Services | Atlanta | Georgia | 30322 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Oncology Associates of Oregon, P.C. | Albany | Oregon | 97321 | — |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | — |
| Oncology Associates of Oregon, P.C. | Springfield | Oregon | 97477 | — |
| Alliance Cancer Specialists, PC | Bensalem | Pennsylvania | 19020 | — |
| Alliance Cancer Specialists, PC | Doylestown | Pennsylvania | 18901 | — |
| Alliance Cancer Specialists, PC | Horsham | Pennsylvania | 19044 | — |
| Alliance Cancer Specialists, PC | Langhorne | Pennsylvania | 19047 | — |
| Alliance Cancer Specialists, PC | Media | Pennsylvania | 19063 | — |
| Alliance Cancer Specialists, PC | Sellersville | Pennsylvania | 18960 | — |
| Alliance Cancer Specialists, PC | Wynnewood | Pennsylvania | 19096 | — |
| Sarah Cannon Research Institute - Pharmacy | Nashville | Tennessee | 37203 | — |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | — |
| Texas Oncology-Northeast Texas | Allen | Texas | 75013 | — |
| Texas Oncology - DFW | Arlington | Texas | 76012 | — |
| Texas Oncology - DFW | Arlington | Texas | 76014 | — |
| Texas Oncology - DFW | Bedford | Texas | 76022 | — |
| Texas Oncology - DFW | Dallas | Texas | 75203 | — |
| Texas Oncology - DFW | Dallas | Texas | 75230 | — |
| Texas Oncology - DFW | Dallas | Texas | 75231 | — |
| Texas Oncology - DFW | Dallas | Texas | 75237 | — |
| Texas Oncology - DFW | Dallas | Texas | 75246 | — |
| Texas Oncology-Northeast Texas | Denison | Texas | 75020 | — |
| Texas Oncology-Northeast Texas | Denton | Texas | 76201 | — |
| Texas Oncology-Northeast Texas | Flower Mound | Texas | 75028 | — |
| Texas Oncology - DFW | Fort Worth | Texas | 76104 | — |
| Texas Oncology - DFW | Grapevine | Texas | 76051 | — |
| US Oncology Investigation Products Center(IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | — |
| Texas Oncology-Northeast Texas | Lewisville | Texas | 75056 | — |
| Texas Oncology-Northeast Texas | Longview | Texas | 75601 | — |
| Texas Oncology-Northeast Texas | McKinney | Texas | 75071 | — |
| Texas Oncology-Northeast Texas | Palestine | Texas | 75801 | — |
| Texas Oncology-Northeast Texas | Paris | Texas | 75460 | — |
| Texas Oncology - DFW | Plano | Texas | 75075 | — |
| Texas Oncology - DFW | Plano | Texas | 75093 | — |
| Texas Oncology - San Antonio | San Antonio | Texas | 78217 | — |
| Texas Oncology - San Antonio | San Antonio | Texas | 78240 | — |
| Texas Oncology-Northeast Texas | Tyler | Texas | 75702 | — |
| Virginia Cancer Specialists, PC | Arlington | Virginia | 22201 | — |
| Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | — |
| Virginia Oncology Associates | Chesapeake | Virginia | 23320 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | — |
| Virginia Cancer Specialists, PC | Manassas | Virginia | 20110 | — |
| Virginia Oncology Associates | Newport News | Virginia | 23606 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Cancer Specialists, PC | Reston | Virginia | 20190 | — |
| Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | — |
| Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care | Salem | Virginia | 24153 | — |
| Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Virginia Oncology Associates | Williamsburg | Virginia | 23188 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06966453, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2026 · Synced Oct 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06966453 live on ClinicalTrials.gov.