A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT06972446. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderately to Severely Active Rheumatoid Arthritis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Study identification
- NCT ID
- NCT06972446
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 180 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 20, 2025 (Actual)
- Primary completion
- Feb 2027 (Estimated)
- Completion
- Nov 2027 (Estimated)
- Last update posted
- Oct 8, 2026
2025 – 2027
United States locations
- U.S. sites
- 49
- U.S. states
- 17
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sun Valley Arthritis Center /ID# 278331 | Peoria | Arizona | 85381 | Recruiting |
| Arthritis And Rheumatism Associates (Ara) - Jonesboro /ID# 272896 | Jonesboro | Arkansas | 72401 | Recruiting |
| Private Practice - Dr. David S. Hallegua /ID# 277608 | Beverly Hills | California | 90211 | Recruiting |
| Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826 | Chula Vista | California | 91910 | Recruiting |
| Newport Huntington Medical Group /ID# 272439 | Huntington Beach | California | 92648-5994 | Recruiting |
| Cohen Medical Centers /ID# 278341 | Thousand Oaks | California | 91360 | Recruiting |
| The Lundquist Institute /ID# 272481 | Torrance | California | 90502 | Recruiting |
| Inland Rheumatology and Osteoporosis Medical Group /ID# 272449 | Upland | California | 91786 | Recruiting |
| Tekton Research - Fort Collins - East Harmony Road /ID# 272472 | Fort Collins | Colorado | 80528 | Recruiting |
| Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298 | Avon Park | Florida | 33825 | Recruiting |
| Clinical Research Of West Florida - Phase I Unit /ID# 272428 | Clearwater | Florida | 33765 | Recruiting |
| Finlay Medical Research - Greenacres /ID# 281654 | Greenacres City | Florida | 33467 | Recruiting |
| Neoclinical Research - Hialeah /ID# 272070 | Hialeah | Florida | 33016 | Recruiting |
| South Florida Rheumatology /ID# 278339 | Hollywood | Florida | 33026 | Recruiting |
| Swati Shah, MD Rheumatology /ID# 273624 | Jacksonville | Florida | 32257 | Recruiting |
| Life Clinical Trials - Colonial Drive - Margate /ID# 272589 | Margate | Florida | 33063 | Recruiting |
| HMD Research LLC /ID# 272432 | Orlando | Florida | 32819 | Recruiting |
| Vitalia Research /ID# 272478 | Palm Beach Gardens | Florida | 33410 | Recruiting |
| Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 272755 | Tampa | Florida | 33606 | Recruiting |
| Northwestern Medicine - Northwestern Memorial Hospital /ID# 275422 | Chicago | Illinois | 60611 | Recruiting |
| Deerbrook Medical Associates /ID# 273439 | Libertyville | Illinois | 60048 | Recruiting |
| Advanced Quality Medical Research /ID# 277824 | Orland Park | Illinois | 60462 | Recruiting |
| Arnold Arthritis & Rheumatology /ID# 278354 | Skokie | Illinois | 60076 | Recruiting |
| Willow Rheumatology and Wellness /ID# 272691 | Willowbrook | Illinois | 60527 | Recruiting |
| Accurate Clinical Research (SMO/Network/Consortium) /ID# 272650 | Lake Charles | Louisiana | 70605 | Recruiting |
| AA Medical Research Center - Grand Blanc /ID# 272496 | Grand Blanc | Michigan | 48439 | Recruiting |
| Sahni Rheumatology & Therapy /ID# 278352 | West Long Branch | New Jersey | 07764 | Recruiting |
| Albuquerque Center For Rheumatology /ID# 272301 | Albuquerque | New Mexico | 87102 | Recruiting |
| Northwell Health Physician Partners Rheumatology At Great Neck /ID# 275621 | Great Neck | New York | 11021 | Recruiting |
| Joint And Muscle Research Institute /ID# 277290 | Charlotte | North Carolina | 28204 | Recruiting |
| DJL Clinical Research - Charlotte /ID# 272387 | Charlotte | North Carolina | 28211-1064 | Recruiting |
| Paramount Medical Research and Consulting /ID# 272474 | Middleburg Heights | Ohio | 44130 | Recruiting |
| Altoona Center For Clinical Research /ID# 272479 | Duncansville | Pennsylvania | 16635 | Recruiting |
| Low Country Rheumatology /ID# 277607 | Summerville | South Carolina | 29486 | Recruiting |
| West Tennessee Research Institute /ID# 272453 | Jackson | Tennessee | 38305 | Recruiting |
| Tekton Research - West Gate /ID# 272270 | Austin | Texas | 78745 | Recruiting |
| Trinity Universal Research Associates - Carrollton /ID# 272577 | Carrollton | Texas | 75007 | Recruiting |
| Arthritis Care Of Texas /ID# 277961 | Corpus Christi | Texas | 78415 | Recruiting |
| Arthritis and Rheumatology Research Institute - Frisco /ID# 272299 | Frisco | Texas | 75035 | Recruiting |
| Accurate Clinical Research - Houston /ID# 272271 | Houston | Texas | 77089-6142 | Recruiting |
| Private Practice - Dr. Laila A. Hassan /ID# 272297 | Houston | Texas | 77089 | Recruiting |
| Care & Cure Clinic /ID# 281684 | Houston | Texas | 77909 | Recruiting |
| Biopharma Informatic /ID# 279189 | Katy | Texas | 77494 | Recruiting |
| Southwest Rheumatology Research /ID# 272268 | Mesquite | Texas | 75150 | Recruiting |
| Texas Rheumatology Research Institute /ID# 278010 | Plano | Texas | 75024 | Recruiting |
| Epic Medical Research /ID# 272656 | Red Oak | Texas | 75154 | Recruiting |
| Fort Bend Rheumatology Associates /ID# 280761 | Sugar Land | Texas | 77479 | Recruiting |
| DM Clinical Research - Tomball /ID# 272452 | Tomball | Texas | 77375 | Recruiting |
| Dm Clinical Research -Tomball Rch /ID# 281787 | Tomball | Texas | 77377 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 47 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06972446, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06972446 live on ClinicalTrials.gov.