A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
Public ClinicalTrials.gov record NCT06977581. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-group, Dose-Ranging Study to Investigate the Efficacy and Safety of PF-07275315 in Adult Participants With Inadequately Controlled Moderate-to-Severe Asthma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 7.5 months. During this time, they will have 9 visits at the study clinic.
Study identification
- NCT ID
- NCT06977581
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 252 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 19, 2025
- Primary completion
- Mar 7, 2027
- Completion
- May 30, 2027
- Last update posted
- May 3, 2026
2025 – 2027
United States locations
- U.S. sites
- 36
- U.S. states
- 19
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Velocity Clinical Research, Mobile | Mobile | Alabama | 36608 | Recruiting |
| Chandler Clinical Trials | Chandler | Arizona | 85224 | Recruiting |
| Antelope Valley Clinical Trials | Lancaster | California | 93534 | Recruiting |
| NewportNativeMD, Inc. | Newport Beach | California | 92663 | Recruiting |
| California Medical Research Associates | Northridge | California | 91324 | Recruiting |
| Allergy and Asthma Associates of Santa Clara Valley Research Center | San Jose | California | 95117 | Recruiting |
| Allergy & Asthma Clinical Research | Walnut Creek | California | 94598 | Recruiting |
| Colorado ENT & Allergy | Colorado Springs | Colorado | 80923 | Recruiting |
| Cpcc-Research Llc | East Point | Georgia | 30344 | Not yet recruiting |
| Christie Clinic - University | Champaign | Illinois | 61820 | Recruiting |
| Innovo Research - Christie Clinic | Champaign | Illinois | 61820 | Recruiting |
| Christie Clinic - Windsor | Champaign | Illinois | 61822 | Recruiting |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | Recruiting |
| North Ingalls Building | Ann Arbor | Michigan | 48109 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Henderson Clinical Trials | Henderson | Nevada | 89052 | Recruiting |
| Rutgers, Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901 | Recruiting |
| Circuit Clinical / Impact Medical Allergy, Asthma & Immunology | Riverdale | New Jersey | 07457 | Recruiting |
| American Health Research | Charlotte | North Carolina | 28277 | Recruiting |
| Clinical Research Of Gastonia | Gastonia | North Carolina | 28054 | Not yet recruiting |
| Stern Research Partners, LLC | Huntersville | North Carolina | 28078 | Recruiting |
| Toledo Institute of Clinical Research Inc. | Toledo | Ohio | 43617 | Recruiting |
| OK Clinical Research | Edmond | Oklahoma | 73034 | Recruiting |
| Allergy, Asthma and Clinical Research | Oklahoma City | Oklahoma | 73120 | Not yet recruiting |
| Layrek Clinical Research | Tulsa | Oklahoma | 74133 | Recruiting |
| Clinical Research Associates of Central PA, LLC | DuBois | Pennsylvania | 15801 | Recruiting |
| Clinical Research of Rock Hill | Rock Hill | South Carolina | 29732 | Recruiting |
| Premier Research Center, LLC | Hendersonville | Tennessee | 37075 | Recruiting |
| South Texas Medical Research Institute, Inc., DBA TTS Research | Boerne | Texas | 78006 | Recruiting |
| Horizon Clinical Research Group | Cypress | Texas | 77429 | Recruiting |
| Alina Clinical Trials, LLC. | Dallas | Texas | 75209 | Recruiting |
| Greater Heights & Memorial Pulmonary and Sleep | Houston | Texas | 77008 | Recruiting |
| Houston Pulmonary Sleep and Allergy Associates | Houston | Texas | 77065 | Recruiting |
| Metroplex Pulmonary and Sleep Center | McKinney | Texas | 75069 | Active, not recruiting |
| Clinical Research Partners, LLC | Richmond | Virginia | 23226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 96 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06977581, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06977581 live on ClinicalTrials.gov.