Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Public ClinicalTrials.gov record NCT06990867. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Optimizing Reperfusion to Improve Outcomes and Neurologic Function (ORION): A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group, Phase 2/3 Study to Evaluate the Efficacy and Safety of JX10 in Acute Ischemic Stroke With Late Presentations
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question the study aims to answer are: 1. JX10 improves functional outcomes as measured by the modified Rankin Scale score when compared with placebo following AIS. 2. Risk of symptomatic intracranial hemorrhage of JX10 in participants with AIS. During Part 1, participants will be randomized to JX 10 (1mg/kg, 3 mg/kg) or placebo. During Part 2, participants will receive JX10 (optimal dose chosen from Part 1) or placebo.
Study identification
- NCT ID
- NCT06990867
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 740 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 14, 2025
- Primary completion
- Oct 30, 2029
- Completion
- Dec 30, 2029
- Last update posted
- Mar 12, 2026
2025 – 2029
United States locations
- U.S. sites
- 17
- U.S. states
- 13
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Corxel Investigational Site | Long Beach | California | 90806 | Recruiting |
| Corxel Investigational Site | Sacramento | California | 95817 | Recruiting |
| Corxel Investigational Site | Colorado Springs | Colorado | 80909 | Recruiting |
| Corxel Investigational Site | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Corxel Investigational Site | Delray Beach | Florida | 33484 | Recruiting |
| Corxel Investigational Site | Chicago | Illinois | 60616 | Recruiting |
| Corxel Investigational Site | Wichita | Kansas | 67214 | Recruiting |
| Corxel Investigational Site | Baltimore | Maryland | 21215 | Recruiting |
| Corxel Investigational Site | Kalamazoo | Michigan | 49048 | Recruiting |
| Corxel Investigational Site | Traverse City | Michigan | 49684 | Recruiting |
| Corxel Investigational Site | St Louis | Missouri | 63110 | Recruiting |
| Corxel Investigational Site | Great Neck | New York | 11021 | Recruiting |
| Corxel Investigational Site | New York | New York | 10029 | Recruiting |
| Corxel Investigational Site | Toledo | Ohio | 43606 | Recruiting |
| Corxel Investigational Site | Tulsa | Oklahoma | 74104 | Recruiting |
| Corxel Investigational Site | Dallas | Texas | 75246 | Recruiting |
| Corxel Investigational Site | Houston | Texas | 77030 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 65 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06990867, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 12, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06990867 live on ClinicalTrials.gov.