ClinicalTrials.gov record
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
ClinicalTrials.gov ID: NCT06992427
Public ClinicalTrials.gov record NCT06992427. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 11:20 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
High-Dose Prophylactic Gabapentin (HOPE) to Prevent Opioid Use for Oral Mucositis Pain During Head and Neck Chemoradiotherapy: A Phase III Clinical Trial
Study identification
- NCT ID
- NCT06992427
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Alliance for Clinical Trials in Oncology
- Other
- Enrollment
- 228 participants
Conditions and interventions
Conditions
Interventions
- Analgesic Agent Drug
- Biospecimen Collection Procedure
- Chemotheraphy Drug
- Gabapentin Drug
- Placebo Drug
- Radiation Therapy Radiation
- Survey Administration Other
Drug · Procedure · Radiation + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 4, 2025
- Primary completion
- Aug 14, 2029
- Completion
- Apr 14, 2031
- Last update posted
- Apr 6, 2026
2025 – 2031
United States locations
- U.S. sites
- 187
- U.S. states
- 21
- U.S. cities
- 152
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Center for Cancer Care - Gilbert | Gilbert | Arizona | 85297 | Recruiting |
| Arizona Center for Cancer Care-Peoria | Peoria | Arizona | 85381 | Recruiting |
| Arizona Center for Cancer Care - Biltmore | Phoenix | Arizona | 85016 | Recruiting |
| Arizona Center for Cancer Care - Phoenix | Phoenix | Arizona | 85027 | Recruiting |
| Arizona Center for Cancer Care - Osborn | Scottsdale | Arizona | 85251 | Recruiting |
| Arizona Center for Cancer Care - Scottsdale | Scottsdale | Arizona | 85258 | Recruiting |
| Arizona Center for Cancer Care-Surprise | Surprise | Arizona | 85374 | Recruiting |
| Arizona Center for Cancer Care | Tempe | Arizona | 85284 | Recruiting |
| AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California | 93301 | Recruiting |
| Kaiser Permanente Dublin | Dublin | California | 94568 | Recruiting |
| Kaiser Permanente-Fremont | Fremont | California | 94538 | Recruiting |
| Kaiser Permanente Fresno Orchard Plaza | Fresno | California | 93720 | Recruiting |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | Suspended |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Suspended |
| Kaiser Permanente- Modesto MOB II | Modesto | California | 95356 | Recruiting |
| Kaiser Permanente-Modesto | Modesto | California | 95356 | Recruiting |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | Recruiting |
| Kaiser Permanente-Roseville | Roseville | California | 95661 | Recruiting |
| Kaiser Permanente Downtown Commons | Sacramento | California | 95814 | Recruiting |
| Kaiser Permanente-South Sacramento | Sacramento | California | 95823 | Recruiting |
| Kaiser Permanente-San Francisco | San Francisco | California | 94115 | Recruiting |
| Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | 95119 | Recruiting |
| Kaiser Permanente San Leandro | San Leandro | California | 94577 | Recruiting |
| Kaiser San Rafael-Gallinas | San Rafael | California | 94903 | Recruiting |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | Recruiting |
| Kaiser Permanente-Santa Rosa | Santa Rosa | California | 95403 | Recruiting |
| Kaiser Permanente-South San Francisco | South San Francisco | California | 94080 | Recruiting |
| Kaiser Permanente-Vallejo | Vallejo | California | 94589 | Recruiting |
| Kaiser Permanente-Walnut Creek | Walnut Creek | California | 94596 | Recruiting |
| Saint Anthony Hospital | Lakewood | Colorado | 80228 | Recruiting |
| Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | 96819 | Recruiting |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | Recruiting |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | Recruiting |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| Rush-Copley Medical Center | Aurora | Illinois | 60504 | Recruiting |
| Advocate Outpatient Center - Aurora | Aurora | Illinois | 60506 | Recruiting |
| Advocate Good Shepherd Hospital | Barrington | Illinois | 60010 | Recruiting |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | Recruiting |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | Recruiting |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | Recruiting |
| Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | Recruiting |
| AMG Crystal Lake - Oncology | Crystal Lake | Illinois | 60014 | Recruiting |
| Carle at The Riverfront | Danville | Illinois | 61832 | Recruiting |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | Recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Recruiting |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | Recruiting |
| Advocate Good Samaritan Hospital | Downers Grove | Illinois | 60515 | Recruiting |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | Recruiting |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | Recruiting |
| Advocate Sherman Hospital | Elgin | Illinois | 60123 | Recruiting |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | Recruiting |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | Recruiting |
| Advocate South Suburban Hospital | Hazel Crest | Illinois | 60429 | Recruiting |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | Recruiting |
| AMG Libertyville - Oncology | Libertyville | Illinois | 60048 | Recruiting |
| Condell Memorial Hospital | Libertyville | Illinois | 60048 | Recruiting |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | Recruiting |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | Recruiting |
| Trinity Medical Center | Moline | Illinois | 61265 | Recruiting |
| Carle BroMenn Medical Center | Normal | Illinois | 61761 | Recruiting |
| Carle Cancer Institute Normal | Normal | Illinois | 61761 | Recruiting |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | Recruiting |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | Recruiting |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | Recruiting |
| Advocate Outpatient Center - Oak Lawn | Oak Lawn | Illinois | 60453 | Recruiting |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | Recruiting |
| Advocate High Tech Medical Park | Palos Heights | Illinois | 60463 | Recruiting |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | Recruiting |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | Recruiting |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | Recruiting |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | Recruiting |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | Recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Springfield Clinic | Springfield | Illinois | 62702 | Recruiting |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | Recruiting |
| Carle Cancer Center | Urbana | Illinois | 61801 | Recruiting |
| Illinois CancerCare - Washington | Washington | Illinois | 61571 | Recruiting |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | Recruiting |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | Recruiting |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | Suspended |
| Saint Luke's Hospital | Cedar Rapids | Iowa | 52402 | Recruiting |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | Recruiting |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | Recruiting |
| Methodist Jennie Edmundson Hospital | Council Bluffs | Iowa | 51503 | Suspended |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | 50501 | Recruiting |
| McFarland Clinic - Jefferson | Jefferson | Iowa | 50129 | Suspended |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | 50158 | Recruiting |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | Recruiting |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | Recruiting |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | Recruiting |
| Freeman Health System | Joplin | Missouri | 64804 | Recruiting |
| Mercy Hospital South | St Louis | Missouri | 63128 | Recruiting |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Logan Health Medical Center | Kalispell | Montana | 59901 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| Nebraska Medicine-Bellevue | Bellevue | Nebraska | 68123 | Recruiting |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | Suspended |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | Recruiting |
| Nebraska Medicine-Village Pointe | Omaha | Nebraska | 68118 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Recruiting |
| Northwell Health Physicians Partners Radiation Medicine at Queens | Forest Hills | New York | 11375 | Recruiting |
| Northwell Health/Center for Advanced Medicine | Lake Success | New York | 11042 | Recruiting |
| Manhattan Eye Ear and Throat Hospital | New York | New York | 10065 | Recruiting |
| Lenox Hill Hospital | New York | New York | 10075 | Recruiting |
| Queens Cancer Center | Rego Park | New York | 11374 | Recruiting |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | Recruiting |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | Recruiting |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | Recruiting |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | Recruiting |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | Recruiting |
| Aultman Health Foundation | Canton | Ohio | 44710 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | Recruiting |
| Geisinger Cancer Center Dickson City | Dickson City | Pennsylvania | 18519 | Recruiting |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | Recruiting |
| Saint Vincent Hospital | Erie | Pennsylvania | 16544 | Recruiting |
| UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | 16121 | Recruiting |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | Recruiting |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | 17109 | Recruiting |
| Jefferson Hospital | Jefferson Hills | Pennsylvania | 15025 | Recruiting |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | Recruiting |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | Recruiting |
| Forbes Hospital | Monroeville | Pennsylvania | 15146 | Recruiting |
| UPMC Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | Recruiting |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | Recruiting |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | 19114 | Recruiting |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | Recruiting |
| Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | 17901 | Recruiting |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | Recruiting |
| Wexford Health and Wellness Pavilion | Wexford | Pennsylvania | 15090 | Recruiting |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | Recruiting |
| Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | Recruiting |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | Recruiting |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | Recruiting |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | Recruiting |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | Recruiting |
| Farmington Health Center | Farmington | Utah | 84025 | Recruiting |
| University of Utah Sugarhouse Health Center | Salt Lake City | Utah | 84106 | Recruiting |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | Recruiting |
| South Jordan Health Center | South Jordan | Utah | 84009 | Recruiting |
| United Hospital Center | Bridgeport | West Virginia | 26330 | Recruiting |
| WVUH-Berkely Medical Center | Martinsburg | West Virginia | 25401 | Recruiting |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | Recruiting |
| Camden Clark Medical Center | Parkersburg | West Virginia | 26101 | Recruiting |
| Princeton Community Hospital | Princeton | West Virginia | 24740 | Recruiting |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | Recruiting |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | Recruiting |
| Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | 53105 | Recruiting |
| Aurora Saint Luke's South Shore | Cudahy | Wisconsin | 53110 | Recruiting |
| Aurora Health Care Germantown Health Center | Germantown | Wisconsin | 53022 | Recruiting |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | Recruiting |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | Recruiting |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | Recruiting |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | Recruiting |
| Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | 54143 | Recruiting |
| Aspirus Medford Hospital | Medford | Wisconsin | 54451 | Recruiting |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | Recruiting |
| Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | 53209 | Recruiting |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | Recruiting |
| Drexel Town Square Health Center | Oak Creek | Wisconsin | 53154 | Recruiting |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | Recruiting |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406 | Recruiting |
| Aspirus Cancer Care - James Beck Cancer Center | Rhinelander | Wisconsin | 54501 | Recruiting |
| Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | 53081 | Recruiting |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Wisconsin | 54481 | Recruiting |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | Recruiting |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | Recruiting |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | Recruiting |
| Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | 53226 | Recruiting |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | Recruiting |
| Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin | 53095 | Recruiting |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06992427, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 6, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06992427 live on ClinicalTrials.gov.