Optimizing Pain Treatment in Children On Mechanical Ventilation
Public ClinicalTrials.gov record NCT06994442. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help with pain while they are on the ventilator, but investigators don't know if this is the best way to manage their pain. Even with strong doses of opioids, more than 90% of these children still feel pain. Other pain medicines, like acetaminophen (also called Tylenol) and ketorolac (also called Toradol), are available but aren't commonly used because we don't know if they help. The goal of this clinical trial is to test if acetaminophen and/or ketorolac can improve pain control and reduce the need for stronger pain medications (opioids) in these children. To learn more about this, participants will be randomly placed in one of four study treatment groups. This means that a computer will decide by chance which group each participant is in, not the doctors running the study. Each group will receive a combination of intravenous acetaminophen, ketorolac or a harmless substance called a placebo. In this clinical trial, placebos help investigators see if the actual medications (acetaminophen and ketorolac) work better than something that doesn't contain medicine. By comparing participants who get the real medicine with those who get the placebo, investigators can find out if these medications effectively decrease pain.
Study identification
- NCT ID
- NCT06994442
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 644 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 2 Months to 17 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2025
- Primary completion
- Jul 30, 2029
- Completion
- Aug 30, 2029
- Last update posted
- Jul 29, 2026
2025 – 2029
United States locations
- U.S. sites
- 16
- U.S. states
- 11
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | Recruiting |
| Children's National Hospital | Washington D.C. | District of Columbia | 20010-2916 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109-1274 | Recruiting |
| Children's Hospital of Michigan | Detroit | Michigan | 48201-2119 | Recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55454-1450 | Recruiting |
| Duke Children's Hospital & Health Center | Durham | North Carolina | 27705-4677 | Recruiting |
| Rainbow Babies and Children's Hospital | Cleveland | Ohio | 44106-4919 | Recruiting |
| Nationwide Children's Hospital | Columbus | Ohio | 43205-2664 | Recruiting |
| Penn State Health/Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | Recruiting |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104-4319 | Recruiting |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15261-0001 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Not yet recruiting |
| Texas Children's Hospital/Baylor College of Medicine | Houston | Texas | 77030-3411 | Not yet recruiting |
| Primary Children's Medical Center | Salt Lake City | Utah | 84112-9023 | Recruiting |
| Wisconsin Children's | Milwaukee | Wisconsin | 53226-3548 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06994442, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 29, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06994442 live on ClinicalTrials.gov.