An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)
Public ClinicalTrials.gov record NCT06996652. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 2 study to assess the ability of adalimumab as compared to placebo to reduce or prevent progression of synuclein-related neurodegeneration in persons with idiopathic REM Sleep Behavior Disorder (RBD). The Primary Endpoint will be change from baseline in expression of the Parkinson Disease Related Pattern (PDRP) will be assessed using change in 18-flurodeoxyglucose (FDG) Positron Emission Tomography (PET) imaging.
Study identification
- NCT ID
- NCT06996652
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 108 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 16, 2026
- Primary completion
- Jul 31, 2029
- Completion
- Dec 31, 2029
- Last update posted
- Aug 23, 2026
2026 – 2030
United States locations
- U.S. sites
- 18
- U.S. states
- 16
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | Not yet recruiting |
| University of Colorado Anschutz | Aurora | Colorado | 80045 | Recruiting |
| Yale Medicine | North Haven | Connecticut | 06473 | Not yet recruiting |
| Parkinson's Disease & Movement Disorders Center of Boca Raton | Boca Raton | Florida | 33486 | Not yet recruiting |
| Emory University School of Medicine | Atlanta | Georgia | 30329 | Not yet recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21287 | Not yet recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Not yet recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55414 | Not yet recruiting |
| Washington University | St Louis | Missouri | 63110 | Not yet recruiting |
| Cleveland Clinic Lou Ruvo Center for Brain Health - Las Vegas | Las Vegas | Nevada | 89106 | Not yet recruiting |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | Not yet recruiting |
| Weill Medical College of Cornell University | New York | New York | 10021 | Not yet recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Not yet recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19107 | Not yet recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29403 | Not yet recruiting |
| University of Texas Houston Medical Center | Houston | Texas | 77030 | Not yet recruiting |
| University of Texas Health Science Center- San Antonio | San Antonio | Texas | 78229 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06996652, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2026 · Synced Sep 13, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06996652 live on ClinicalTrials.gov.