A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH
Public ClinicalTrials.gov record NCT07000136. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Effect of AZD0780 on Low-Density Lipoprotein Cholesterol in Patients With Heterozygous Familial Hypercholesterolaemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study to evaluate the efficacy and safety of AZD0780 in adults with HeFH and elevated LDL-C, either with clinical ASCVD and LDL-C levels of 55 mg/dL or higher or without clinical ASCVD and LDL-C levels of 70 mg/dL or higher. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood. Placebo will be used for comparison, and neither the participants nor the Investigators will know who is receiving the AZD0780 medication and who is receiving the placebo until the end of study. The total length of the study for an individual participant will be up to approximately 56 weeks, including a screening period of up to 14 days, treatment with AZD0780 or placebo for 52 weeks, and a safety follow-up period of 10 days.
Study identification
- NCT ID
- NCT07000136
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 473 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 9, 2025
- Primary completion
- Jan 3, 2027
- Completion
- Jan 3, 2027
- Last update posted
- Jul 15, 2026
2025 – 2027
United States locations
- U.S. sites
- 19
- U.S. states
- 12
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Garden Grove | California | 92844 | — |
| Research Site | San Diego | California | 92111 | — |
| Research Site | Miami Lakes | Florida | 33016 | — |
| Research Site | Orlando | Florida | 32807 | — |
| Research Site | Peachtree Corners | Georgia | 30092 | — |
| Research Site | Chicago | Illinois | 60607 | — |
| Research Site | Hammond | Louisiana | 70403 | — |
| Research Site | Las Vegas | Nevada | 89119 | — |
| Research Site | New York | New York | 10029 | — |
| Research Site | Morganton | North Carolina | 28655 | — |
| Research Site | Cincinnati | Ohio | 45227 | — |
| Research Site | Lima | Ohio | 45801 | — |
| Research Site | Chattanooga | Tennessee | 37404 | — |
| Research Site | Houston | Texas | 77043 | — |
| Research Site | Humble | Texas | 77338 | — |
| Research Site | Kingwood | Texas | 77345 | — |
| Research Site | McAllen | Texas | 78503 | — |
| Research Site | Mesquite | Texas | 75149 | — |
| Research Site | Redmond | Washington | 98052 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07000136, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 15, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07000136 live on ClinicalTrials.gov.