A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

ClinicalTrials.gov ID: NCT07000357

Public ClinicalTrials.gov record NCT07000357. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 4, 2026, 4:40 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Effect of AZD0780 on Major Adverse Cardiovascular Events in Patients With Established Atherosclerotic Cardiovascular Disease (ASCVD) or at High Risk for a First ASCVD Event

Study identification

NCT ID: NCT07000357
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 15,100 participants

Conditions and interventions

Conditions

Cardiovascular Disease

Interventions

AZD0780 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 3, 2025
Primary completion: Oct 25, 2029
Completion: Oct 25, 2029
Last update posted: Apr 16, 2026

2025 – 2029

United States locations

U.S. sites: 293
U.S. states: 41
U.S. cities: 246

Facility	City	State	ZIP	Site status
Research Site	Birmingham	Alabama	35205	Recruiting
Research Site	Fairhope	Alabama	36532	Recruiting
Research Site	Foley	Alabama	36535	Recruiting
Research Site	Huntsville	Alabama	35801	Recruiting
Research Site	Mobile	Alabama	36608	Recruiting
Research Site	Saraland	Alabama	36571	Recruiting
Research Site	Vestavia Hills	Alabama	35216	Recruiting
Research Site	Gilbert	Arizona	85296	Recruiting
Research Site	Glendale	Arizona	85308	Recruiting
Research Site	Mesa	Arizona	85206	Suspended
Research Site	Peoria	Arizona	85382	Recruiting
Research Site	Phoenix	Arizona	85014	Recruiting
Research Site	Phoenix	Arizona	85051	Recruiting
Research Site	Phoenix	Arizona	85053	Recruiting
Research Site	Scottsdale	Arizona	85260	Recruiting
Research Site	Tempe	Arizona	85283	Recruiting
Research Site	Tucson	Arizona	85715	Recruiting
Research Site	Tucson	Arizona	85741	Suspended
Research Site	Tucson	Arizona	85745	Recruiting
Research Site	Beverly Hills	California	90211	Recruiting
Research Site	Canoga Park	California	91303	Recruiting
Research Site	Castroville	California	95012	Recruiting
Research Site	Chula Vista	California	91911	Recruiting
Research Site	Fountain Valley	California	92708	Recruiting
Research Site	Garden Grove	California	92844	Recruiting
Research Site	La Jolla	California	92037	Not yet recruiting
Research Site	Lake Forest	California	92630	Withdrawn
Research Site	Lancaster	California	93534	Recruiting
Research Site	Loma Linda	California	92350	Recruiting
Research Site	Loma Linda	California	92357	Not yet recruiting
Research Site	Los Angeles	California	90017	Recruiting
Research Site	Los Angeles	California	90035	Recruiting
Research Site	Lynwood	California	90262	Recruiting
Research Site	Monterey Park	California	91754	Recruiting
Research Site	Newport Beach	California	92663	Recruiting
Research Site	Norco	California	92860	Recruiting
Research Site	Northridge	California	91325	Recruiting
Research Site	Pomona	California	91768	Recruiting
Research Site	Poway	California	92064	Withdrawn
Research Site	Riverside	California	92503	Recruiting
Research Site	Sacramento	California	95817	Not yet recruiting
Research Site	San Diego	California	92111	Recruiting
Research Site	San Dimas	California	91773	Recruiting
Research Site	Santa Ana	California	92705	Recruiting
Research Site	Stanford	California	94305	Not yet recruiting
Research Site	Tarzana	California	91356	Recruiting
Research Site	Thousand Oaks	California	91360	Recruiting
Research Site	Torrance	California	90502	Not yet recruiting
Research Site	West Hills	California	91307	Recruiting
Research Site	Stamford	Connecticut	06905	Withdrawn
Research Site	Waterbury	Connecticut	06708	Recruiting
Research Site	Boca Raton	Florida	33486	Recruiting
Research Site	Clearwater	Florida	33756	Recruiting
Research Site	Coral Gables	Florida	33134	Recruiting
Research Site	Crystal River	Florida	34429	Recruiting
Research Site	DeLand	Florida	32720	Recruiting
Research Site	Fleming Island	Florida	32003	Recruiting
Research Site	Fort Lauderdale	Florida	33308	Recruiting
Research Site	Fort Lauderdale	Florida	33316	Suspended
Research Site	Gainesville	Florida	32608	Withdrawn
Research Site	Gainesville	Florida	32610	Not yet recruiting
Research Site	Hallandale	Florida	33009	Recruiting
Research Site	Hialeah	Florida	33012	Withdrawn
Research Site	Hollywood	Florida	33021	Recruiting
Research Site	Homestead	Florida	33030	Recruiting
Research Site	Inverness	Florida	34452	Recruiting
Research Site	Jacksonville	Florida	32204	Recruiting
Research Site	Jacksonville	Florida	32205	Recruiting
Research Site	Jacksonville	Florida	32209	Not yet recruiting
Research Site	Jacksonville	Florida	32216	Recruiting
Research Site	Lake City	Florida	32055	Recruiting
Research Site	Lake Worth	Florida	33462	Recruiting
Research Site	Lakeland	Florida	33805	Recruiting
Research Site	Lakeland	Florida	33813	Recruiting
Research Site	Largo	Florida	33777	Recruiting
Research Site	Longwood	Florida	32750	Recruiting
Research Site	Maitland	Florida	32751	Recruiting
Research Site	Margate	Florida	33063	Recruiting
Research Site	Miami	Florida	33176	Recruiting
Research Site	Miami	Florida	33186	Recruiting
Research Site	Miami	Florida	33269	Recruiting
Research Site	Miami Lakes	Florida	33014	Recruiting
Research Site	Miami Lakes	Florida	33016	Recruiting
Research Site	Naples	Florida	34102	Recruiting
Research Site	New Port Richey	Florida	34652	Recruiting
Research Site	New Port Richey	Florida	34653	Recruiting
Research Site	Ocala	Florida	34470	Recruiting
Research Site	Orlando	Florida	32801	Recruiting
Research Site	Orlando	Florida	32807	Recruiting
Research Site	Orlando	Florida	32825	Recruiting
Research Site	Palm Harbor	Florida	34684	Recruiting
Research Site	Palmetto Bay	Florida	33157	Recruiting
Research Site	Pembroke Pines	Florida	33029	Recruiting
Research Site	Port Charlotte	Florida	33952	Recruiting
Research Site	Safety Harbor	Florida	34695	Recruiting
Research Site	Saint Augustine	Florida	32086	Recruiting
Research Site	Seminole	Florida	33777	Recruiting
Research Site	Tampa	Florida	33625	Recruiting
Research Site	West Palm Beach	Florida	33401	Recruiting
Research Site	Atlanta	Georgia	30322	Not yet recruiting
Research Site	Atlanta	Georgia	30328	Recruiting
Research Site	Atlanta	Georgia	30342	Recruiting
Research Site	Canton	Georgia	30114	Recruiting
Research Site	Decatur	Georgia	30030	Recruiting
Research Site	Decatur	Georgia	30033	Recruiting
Research Site	Hinesville	Georgia	31313	Recruiting
Research Site	Macon	Georgia	31210	Recruiting
Research Site	Peachtree Corners	Georgia	30092	Recruiting
Research Site	Riverdale	Georgia	30274	Recruiting
Research Site	Stockbridge	Georgia	30281	Recruiting
Research Site	Tucker	Georgia	30084	Recruiting
Research Site	Union City	Georgia	30291	Recruiting
Research Site	Woodstock	Georgia	30189	Withdrawn
Research Site	Chicago	Illinois	60607	Recruiting
Research Site	Gurnee	Illinois	60031	Recruiting
Research Site	Melrose Park	Illinois	60160	Recruiting
Research Site	Tinley Park	Illinois	60477	Recruiting
Research Site	Winfield	Illinois	60190	Recruiting
Research Site	Carmel	Indiana	46290	Recruiting
Research Site	Evansville	Indiana	47714	Recruiting
Research Site	Evansville	Indiana	47715	Recruiting
Research Site	Munster	Indiana	46321	Recruiting
Research Site	Ames	Iowa	50010	Recruiting
Research Site	Waterloo	Iowa	50701	Recruiting
Research Site	West Des Moines	Iowa	50266	Recruiting
Research Site	Kansas City	Kansas	66112	Recruiting
Research Site	Kansas City	Kansas	66160	Recruiting
Research Site	Wichita	Kansas	67218	Recruiting
Research Site	Bowling Green	Kentucky	42101	Recruiting
Research Site	Lexington	Kentucky	40503	Recruiting
Research Site	Owensboro	Kentucky	42301	Recruiting
Research Site	Paducah	Kentucky	42001	Recruiting
Research Site	Versailles	Kentucky	40383	Recruiting
Research Site	Bossier City	Louisiana	71111	Recruiting
Research Site	Covington	Louisiana	70433	Recruiting
Research Site	Hammond	Louisiana	70403	Recruiting
Research Site	Lake Charles	Louisiana	70601	Recruiting
Research Site	Shreveport	Louisiana	71105	Recruiting
Research Site	Zachary	Louisiana	70791	Recruiting
Research Site	Bangor	Maine	04401	Recruiting
Research Site	Scarborough	Maine	04074	Recruiting
Research Site	Annapolis	Maryland	21401	Recruiting
Research Site	Baltimore	Maryland	21229	Recruiting
Research Site	Beltsville	Maryland	20705	Not yet recruiting
Research Site	Columbia	Maryland	21044	Not yet recruiting
Research Site	Lanham	Maryland	20706	Recruiting
Research Site	Oxon Hill	Maryland	20745	Recruiting
Research Site	Pikesville	Maryland	21208	Recruiting
Research Site	Rockville	Maryland	20850	Withdrawn
Research Site	Boston	Massachusetts	02111	Recruiting
Research Site	Brookline	Massachusetts	02446	Recruiting
Research Site	Haverhill	Massachusetts	01830	Not yet recruiting
Research Site	Dearborn Heights	Michigan	48127	Recruiting
Research Site	Detroit	Michigan	48202	Not yet recruiting
Research Site	Farmington Hills	Michigan	48336	Recruiting
Research Site	Southfield	Michigan	48034	Recruiting
Research Site	Southfield	Michigan	48076	Recruiting
Research Site	Ypsilanti	Michigan	48197	Not yet recruiting
Research Site	Duluth	Minnesota	55805	Recruiting
Research Site	Minneapolis	Minnesota	55423	Recruiting
Research Site	Minneapolis	Minnesota	55435	Recruiting
Research Site	Saint Cloud	Minnesota	56303	Recruiting
Research Site	Bridgeton	Missouri	63044	Recruiting
Research Site	Chesterfield	Missouri	63005	Recruiting
Research Site	Hazelwood	Missouri	63042	Recruiting
Research Site	Jefferson City	Missouri	65109	Recruiting
Research Site	Kansas City	Missouri	64128	Withdrawn
Research Site	Kansas City	Missouri	64151	Recruiting
Research Site	Springfield	Missouri	65807	Recruiting
Research Site	St Louis	Missouri	63110	Not yet recruiting
Research Site	St Louis	Missouri	63119	Completed
Research Site	Missoula	Montana	59808	Recruiting
Research Site	Elkhorn	Nebraska	68022	Recruiting
Research Site	Fremont	Nebraska	68025	Recruiting
Research Site	Omaha	Nebraska	68144	Recruiting
Research Site	Henderson	Nevada	89014	Withdrawn
Research Site	Las Vegas	Nevada	89102	Recruiting
Research Site	Las Vegas	Nevada	89119	Recruiting
Research Site	Las Vegas	Nevada	89128	Recruiting
Research Site	Lebanon	New Hampshire	03756	Not yet recruiting
Research Site	Bridgewater	New Jersey	08807	Recruiting
Research Site	Somerset	New Jersey	08873	Recruiting
Research Site	Brooklyn	New York	11201	Recruiting
Research Site	Buffalo	New York	14217	Recruiting
Research Site	Laurelton	New York	11413	Recruiting
Research Site	New York	New York	10029	Not yet recruiting
Research Site	The Bronx	New York	10451	Recruiting
Research Site	Asheville	North Carolina	28803	Not yet recruiting
Research Site	Chapel Hill	North Carolina	27599	Not yet recruiting
Research Site	Durham	North Carolina	27701	Recruiting
Research Site	Durham	North Carolina	27705	Not yet recruiting
Research Site	Greensboro	North Carolina	27408	Suspended
Research Site	Monroe	North Carolina	28112	Recruiting
Research Site	Morehead City	North Carolina	28557	Recruiting
Research Site	Morganton	North Carolina	28655	Recruiting
Research Site	New Bern	North Carolina	28562	Recruiting
Research Site	Wilmington	North Carolina	28401	Recruiting
Research Site	Winston-Salem	North Carolina	27157	Recruiting
Research Site	Fargo	North Dakota	58104	Recruiting
Research Site	Cincinnati	Ohio	45220	Recruiting
Research Site	Columbus	Ohio	43213	Recruiting
Research Site	Dublin	Ohio	43016	Withdrawn
Research Site	Lima	Ohio	45805	Recruiting
Research Site	Maumee	Ohio	43537	Recruiting
Research Site	Munroe Falls	Ohio	44262	Suspended
Research Site	Norman	Oklahoma	73069	Recruiting
Research Site	Portland	Oregon	97210	Withdrawn
Research Site	Camp Hill	Pennsylvania	17011	Recruiting
Research Site	Duncansville	Pennsylvania	16635	Recruiting
Research Site	Horsham	Pennsylvania	19044	Recruiting
Research Site	Philadelphia	Pennsylvania	19114	Recruiting
Research Site	Smithfield	Pennsylvania	15478	Recruiting
Research Site	West Chester	Pennsylvania	19380	Recruiting
Research Site	Wilkes-Barre	Pennsylvania	18711	Withdrawn
Research Site	Yardley	Pennsylvania	19067	Recruiting
Research Site	Providence	Rhode Island	02908	Recruiting
Research Site	Charleston	South Carolina	29402	Not yet recruiting
Research Site	Fort Mill	South Carolina	29707	Recruiting
Research Site	Mauldin	South Carolina	29662	Recruiting
Research Site	Myrtle Beach	South Carolina	29572	Recruiting
Research Site	North Charleston	South Carolina	29405	Recruiting
Research Site	North Charleston	South Carolina	29406	Recruiting
Research Site	Rapid City	South Dakota	57701	Recruiting
Research Site	Chattanooga	Tennessee	37404	Recruiting
Research Site	Chattanooga	Tennessee	37421	Recruiting
Research Site	Elizabethton	Tennessee	37643	Withdrawn
Research Site	Knoxville	Tennessee	37849	Recruiting
Research Site	Knoxville	Tennessee	37912	Recruiting
Research Site	Knoxville	Tennessee	37938	Recruiting
Research Site	Memphis	Tennessee	38119	Recruiting
Research Site	Memphis	Tennessee	38128	Recruiting
Research Site	Morristown	Tennessee	37813	Recruiting
Research Site	Nashville	Tennessee	37232	Not yet recruiting
Research Site	Tullahoma	Tennessee	37388	Recruiting
Research Site	Amarillo	Texas	79106	Recruiting
Research Site	Beaumont	Texas	77706	Recruiting
Research Site	Brownsville	Texas	78526	Recruiting
Research Site	Corpus Christi	Texas	78404	Recruiting
Research Site	Dallas	Texas	75216	Recruiting
Research Site	Dallas	Texas	75234	Recruiting
Research Site	Dallas	Texas	75246	Recruiting
Research Site	DeSoto	Texas	75115	Recruiting
Research Site	El Paso	Texas	79902	Recruiting
Research Site	El Paso	Texas	79905	Recruiting
Research Site	Euless	Texas	76040	Recruiting
Research Site	Houston	Texas	77002	Recruiting
Research Site	Houston	Texas	77025	Recruiting
Research Site	Houston	Texas	77034	Recruiting
Research Site	Houston	Texas	77043	Recruiting
Research Site	Houston	Texas	77087	Recruiting
Research Site	Humble	Texas	77338	Recruiting
Research Site	Irving	Texas	75061	Recruiting
Research Site	Katy	Texas	77450	Recruiting
Research Site	Kingwood	Texas	77339	Not yet recruiting
Research Site	Kingwood	Texas	77345	Recruiting
Research Site	McAllen	Texas	78503	Recruiting
Research Site	McKinney	Texas	75069	Recruiting
Research Site	Mesquite	Texas	75149	Recruiting
Research Site	Paris	Texas	75462	Recruiting
Research Site	Pearland	Texas	77584	Suspended
Research Site	Pharr	Texas	78577	Recruiting
Research Site	Plano	Texas	75093	Recruiting
Research Site	San Antonio	Texas	78207	Recruiting
Research Site	San Antonio	Texas	78212	Recruiting
Research Site	Sugar Land	Texas	77478	Recruiting
Research Site	Sugar Land	Texas	77479	Recruiting
Research Site	Temple	Texas	76508	Recruiting
Research Site	Tomball	Texas	77375	Recruiting
Research Site	Tyler	Texas	75701	Recruiting
Research Site	Victoria	Texas	77901	Recruiting
Research Site	Bountiful	Utah	84010	Recruiting
Research Site	Ogden	Utah	84404	Suspended
Research Site	Ogden	Utah	84405	Recruiting
Research Site	Roy	Utah	84067	Withdrawn
Research Site	Salt Lake City	Utah	84124	Withdrawn
Research Site	Salt Lake City	Utah	84148	Recruiting
Research Site	White River Junction	Vermont	05001	Not yet recruiting
Research Site	Charlottesville	Virginia	22911	Suspended
Research Site	Fairfax	Virginia	22031	Not yet recruiting
Research Site	Falls Church	Virginia	22042	Recruiting
Research Site	Henrico	Virginia	23229	Not yet recruiting
Research Site	Hopewell	Virginia	23860	Recruiting
Research Site	Manassas	Virginia	20110	Recruiting
Research Site	Newport News	Virginia	23606	Recruiting
Research Site	Norfolk	Virginia	23504	Recruiting
Research Site	Richmond	Virginia	23219	Recruiting
Research Site	Suffolk	Virginia	23435	Recruiting
Research Site	Redmond	Washington	98052	Recruiting
Research Site	Renton	Washington	98057	Recruiting
Research Site	Seattle	Washington	98122	Recruiting
Research Site	Tacoma	Washington	98405	Recruiting
Research Site	Morgantown	West Virginia	26505	Recruiting
Research Site	Milwaukee	Wisconsin	64111	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 951 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07000357, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 16, 2026 · Synced May 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07000357 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →