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ClinicalTrials.gov record
Recruiting Phase 3 Interventional

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

ClinicalTrials.gov ID: NCT07000357

Public ClinicalTrials.gov record NCT07000357. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 2, 2026, 3:57 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Effect of AZD0780 on Major Adverse Cardiovascular Events in Patients With Established Atherosclerotic Cardiovascular Disease (ASCVD) or at High Risk for a First ASCVD Event

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established ASCVD or at high risk for a first ASCVD event. The effect of AZD0780 vs placebo on the risk of MACE-PLUS will be evaluated from randomisation until the primary analysis censoring date (PACD). The Study Closure Visit will be scheduled to occur after the PACD and will be the final visit for each participant in the study.

Study identification

NCT ID
NCT07000357
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
15,100 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 3, 2025
Primary completion
Oct 25, 2029
Completion
Oct 25, 2029
Last update posted
Aug 23, 2026

2025 – 2029

United States locations

U.S. sites
357
U.S. states
46
U.S. cities
287
Facility City State ZIP Site status
Research Site Athens Alabama 35611 Recruiting
Research Site Birmingham Alabama 35205 Not yet recruiting
Research Site Fairhope Alabama 36532 Recruiting
Research Site Foley Alabama 36535 Recruiting
Research Site Huntsville Alabama 35801 Not yet recruiting
Research Site Irondale Alabama 35210 Not yet recruiting
Research Site Mobile Alabama 36608 Recruiting
Research Site Northport Alabama 35476 Not yet recruiting
Research Site Saraland Alabama 36571 Recruiting
Research Site Vestavia Hills Alabama 35216 Recruiting
Research Site Gilbert Arizona 85295 Not yet recruiting
Research Site Gilbert Arizona 85296 Recruiting
Research Site Glendale Arizona 85308 Terminated
Research Site Mesa Arizona 85206 Withdrawn
Research Site Peoria Arizona 85382 Recruiting
Research Site Phoenix Arizona 85006 Not yet recruiting
Research Site Phoenix Arizona 85014 Recruiting
Research Site Phoenix Arizona 85051 Recruiting
Research Site Phoenix Arizona 85053 Recruiting
Research Site Scottsdale Arizona 85260 Recruiting
Research Site Tempe Arizona 85283 Recruiting
Research Site Tucson Arizona 85715 Recruiting
Research Site Tucson Arizona 85741 Withdrawn
Research Site Tucson Arizona 85745 Recruiting
Research Site Little Rock Arkansas 72205 Recruiting
Research Site Beverly Hills California 90211 Recruiting
Research Site Canoga Park California 91303 Recruiting
Research Site Castroville California 95012 Recruiting
Research Site Chula Vista California 91911 Recruiting
Research Site Fountain Valley California 92708 Recruiting
Research Site Garden Grove California 92844 Recruiting
Research Site La Jolla California 92037 Not yet recruiting
Research Site Lake Forest California 92630 Withdrawn
Research Site Lancaster California 93534 Recruiting
Research Site Loma Linda California 92350 Recruiting
Research Site Loma Linda California 92357 Recruiting
Research Site Los Angeles California 90017 Recruiting
Research Site Los Angeles California 90035 Recruiting
Research Site Lynwood California 90262 Recruiting
Research Site Monterey Park California 91754 Recruiting
Research Site Newport Beach California 92663 Recruiting
Research Site Norco California 92860 Recruiting
Research Site Northridge California 91325 Recruiting
Research Site Pomona California 91768 Recruiting
Research Site Poway California 92064 Withdrawn
Research Site Riverside California 92503 Recruiting
Research Site Sacramento California 95817 Not yet recruiting
Research Site San Diego California 92111 Recruiting
Research Site San Diego California 92123 Not yet recruiting
Research Site San Dimas California 91773 Recruiting
Research Site San Francisco California 94143 Not yet recruiting
Research Site Santa Ana California 92705 Suspended
Research Site Stanford California 94305 Not yet recruiting
Research Site Tarzana California 91356 Recruiting
Research Site Thousand Oaks California 91360 Recruiting
Research Site Torrance California 90502 Recruiting
Research Site West Hills California 91307 Recruiting
Research Site Thornton Colorado 80023 Not yet recruiting
Research Site Stamford Connecticut 06905 Withdrawn
Research Site Waterbury Connecticut 06708 Recruiting
Research Site Newark Delaware 19713 Not yet recruiting
Research Site Boca Raton Florida 33486 Suspended
Research Site Clearwater Florida 33756 Recruiting
Research Site Coral Gables Florida 33134 Recruiting
Research Site Crystal River Florida 34429 Recruiting
Research Site DeLand Florida 32720 Recruiting
Research Site Fleming Island Florida 32003 Recruiting
Research Site Fort Lauderdale Florida 33308 Recruiting
Research Site Fort Lauderdale Florida 33316 Withdrawn
Research Site Gainesville Florida 32608 Withdrawn
Research Site Gainesville Florida 32610 Not yet recruiting
Research Site Hallandale Florida 33009 Recruiting
Research Site Hialeah Florida 33012 Withdrawn
Research Site Hollywood Florida 33021 Recruiting
Research Site Homestead Florida 33030 Recruiting
Research Site Inverness Florida 34452 Suspended
Research Site Jacksonville Florida 32204 Suspended
Research Site Jacksonville Florida 32205 Terminated
Research Site Jacksonville Florida 32209 Not yet recruiting
Research Site Jacksonville Florida 32216 Recruiting
Research Site Lake City Florida 32055 Recruiting
Research Site Lake Worth Florida 33462 Recruiting
Research Site Lakeland Florida 33805 Recruiting
Research Site Lakeland Florida 33813 Recruiting
Research Site Largo Florida 33777 Recruiting
Research Site Longwood Florida 32750 Recruiting
Research Site Maitland Florida 32751 Recruiting
Research Site Margate Florida 33063 Recruiting
Research Site Miami Florida 33176 Recruiting
Research Site Miami Florida 33186 Recruiting
Research Site Miami Florida 33269 Recruiting
Research Site Miami Lakes Florida 33014 Recruiting
Research Site Miami Lakes Florida 33016 Recruiting
Research Site Naples Florida 34102 Recruiting
Research Site New Port Richey Florida 34652 Recruiting
Research Site New Port Richey Florida 34653 Recruiting
Research Site Ocala Florida 34470 Recruiting
Research Site Orlando Florida 32801 Recruiting
Research Site Orlando Florida 32807 Recruiting
Research Site Orlando Florida 32825 Recruiting
Research Site Palm Harbor Florida 34684 Recruiting
Research Site Palmetto Bay Florida 33157 Suspended
Research Site Pembroke Pines Florida 33029 Recruiting
Research Site Plantation Florida 33324 Not yet recruiting
Research Site Port Charlotte Florida 33952 Recruiting
Research Site Safety Harbor Florida 34695 Recruiting
Research Site Saint Augustine Florida 32086 Recruiting
Research Site Seminole Florida 33777 Recruiting
Research Site Tampa Florida 33625 Recruiting
Research Site West Palm Beach Florida 33401 Recruiting
Research Site Atlanta Georgia 30322 Recruiting
Research Site Atlanta Georgia 30328 Recruiting
Research Site Atlanta Georgia 30342 Recruiting
Research Site Canton Georgia 30114 Recruiting
Research Site Decatur Georgia 30030 Recruiting
Research Site Decatur Georgia 30033 Recruiting
Research Site Hinesville Georgia 31313 Recruiting
Research Site Macon Georgia 31210 Recruiting
Research Site Peachtree Corners Georgia 30092 Suspended
Research Site Riverdale Georgia 30274 Recruiting
Research Site Stockbridge Georgia 30281 Suspended
Research Site Tucker Georgia 30084 Recruiting
Research Site Union City Georgia 30291 Recruiting
Research Site Woodstock Georgia 30189 Withdrawn
Research Site Meridian Idaho 83642 Not yet recruiting
Research Site Arlington Heights Illinois 60005 Not yet recruiting
Research Site Chicago Illinois 60607 Recruiting
Research Site Chicago Illinois 60611 Withdrawn
Research Site Chicago Illinois 60612 Not yet recruiting
Research Site Chicago Illinois 60639 Not yet recruiting
Research Site Gurnee Illinois 60031 Recruiting
Research Site Melrose Park Illinois 60160 Recruiting
Research Site Tinley Park Illinois 60477 Recruiting
Research Site Winfield Illinois 60190 Recruiting
Research Site Carmel Indiana 46290 Withdrawn
Research Site Evansville Indiana 47714 Recruiting
Research Site Evansville Indiana 47715 Recruiting
Research Site Indianapolis Indiana 46202 Recruiting
Research Site Munster Indiana 46321 Suspended
Research Site Ames Iowa 50010 Recruiting
Research Site Council Bluffs Iowa 51501 Not yet recruiting
Research Site Iowa City Iowa 52242 Not yet recruiting
Research Site Waterloo Iowa 50701 Recruiting
Research Site West Des Moines Iowa 50266 Recruiting
Research Site Kansas City Kansas 66112 Recruiting
Research Site Kansas City Kansas 66160 Recruiting
Research Site Topeka Kansas 66606 Not yet recruiting
Research Site Wichita Kansas 67218 Suspended
Research Site Bowling Green Kentucky 42101 Recruiting
Research Site Lexington Kentucky 40503 Recruiting
Research Site Lexington Kentucky 40506 Not yet recruiting
Research Site Owensboro Kentucky 42301 Recruiting
Research Site Owensboro Kentucky 42303 Recruiting
Research Site Paducah Kentucky 42001 Recruiting
Research Site Versailles Kentucky 40383 Recruiting
Research Site Bossier City Louisiana 71111 Suspended
Research Site Covington Louisiana 70433 Recruiting
Research Site Hammond Louisiana 70403 Recruiting
Research Site Lake Charles Louisiana 70601 Recruiting
Research Site Saint Francisville Louisiana 70775 Not yet recruiting
Research Site Shreveport Louisiana 71105 Recruiting
Research Site Slidell Louisiana 70458 Not yet recruiting
Research Site Zachary Louisiana 70791 Recruiting
Research Site Bangor Maine 04401 Recruiting
Research Site Scarborough Maine 04074 Recruiting
Research Site Annapolis Maryland 21401 Recruiting
Research Site Baltimore Maryland 21201 Not yet recruiting
Research Site Baltimore Maryland 21209 Not yet recruiting
Research Site Baltimore Maryland 21229 Recruiting
Research Site Beltsville Maryland 20705 Recruiting
Research Site Bowie Maryland 20715 Not yet recruiting
Research Site Columbia Maryland 21044 Recruiting
Research Site Lanham Maryland 20706 Recruiting
Research Site Olney Maryland 20832 Not yet recruiting
Research Site Oxon Hill Maryland 20745 Recruiting
Research Site Pikesville Maryland 21208 Recruiting
Research Site Rockville Maryland 20850 Withdrawn
Research Site Salisbury Maryland 21801 Recruiting
Research Site Boston Massachusetts 02111 Recruiting
Research Site Boston Massachusetts 02114 Not yet recruiting
Research Site Brookline Massachusetts 02446 Recruiting
Research Site Haverhill Massachusetts 01830 Not yet recruiting
Research Site Worcester Massachusetts 01605 Not yet recruiting
Research Site Dearborn Heights Michigan 48127 Recruiting
Research Site Detroit Michigan 48202 Not yet recruiting
Research Site Farmington Hills Michigan 48336 Recruiting
Research Site Pontiac Michigan 48341 Not yet recruiting
Research Site Saginaw Michigan 48601 Not yet recruiting
Research Site Southfield Michigan 48034 Terminated
Research Site Southfield Michigan 48076 Recruiting
Research Site Ypsilanti Michigan 48197 Not yet recruiting
Research Site Duluth Minnesota 55805 Recruiting
Research Site Minneapolis Minnesota 55423 Recruiting
Research Site Minneapolis Minnesota 55435 Recruiting
Research Site Saint Cloud Minnesota 56303 Recruiting
Research Site Bridgeton Missouri 63044 Recruiting
Research Site Chesterfield Missouri 63005 Recruiting
Research Site Hazelwood Missouri 63042 Recruiting
Research Site Jefferson City Missouri 65109 Recruiting
Research Site Kansas City Missouri 64111 Recruiting
Research Site Kansas City Missouri 64128 Withdrawn
Research Site Kansas City Missouri 64151 Recruiting
Research Site Springfield Missouri 65807 Recruiting
Research Site St Louis Missouri 63110 Not yet recruiting
Research Site St Louis Missouri 63119 Completed
Research Site St Louis Missouri 63128 Not yet recruiting
Research Site Missoula Montana 59808 Recruiting
Research Site Elkhorn Nebraska 68022 Recruiting
Research Site Fremont Nebraska 68025 Recruiting
Research Site Omaha Nebraska 68114 Not yet recruiting
Research Site Omaha Nebraska 68144 Suspended
Research Site Henderson Nevada 89014 Withdrawn
Research Site Las Vegas Nevada 89102 Recruiting
Research Site Las Vegas Nevada 89119 Recruiting
Research Site Las Vegas Nevada 89128 Recruiting
Research Site Lebanon New Hampshire 03756 Recruiting
Research Site Bridgewater New Jersey 08807 Recruiting
Research Site Elmer New Jersey 08318 Not yet recruiting
Research Site Haddon Heights New Jersey 08035 Not yet recruiting
Research Site Sewell New Jersey 08080 Not yet recruiting
Research Site Somerset New Jersey 08873 Recruiting
Research Site Albuquerque New Mexico 87106 Not yet recruiting
Research Site Albany New York 12205 Not yet recruiting
Research Site Albany New York 12211 Not yet recruiting
Research Site Brooklyn New York 11201 Recruiting
Research Site Buffalo New York 14217 Recruiting
Research Site Laurelton New York 11413 Recruiting
Research Site New York New York 10021 Not yet recruiting
Research Site New York New York 10029 Recruiting
Research Site New York New York 11355 Not yet recruiting
Research Site Patchogue New York 11772 Not yet recruiting
Research Site Poughkeepsie New York 12601 Not yet recruiting
Research Site Rochester New York 14642 Not yet recruiting
Research Site Rosedale New York 11422 Not yet recruiting
Research Site Saratoga Springs New York 12866 Recruiting
Research Site Smithtown New York 11787 Withdrawn
Research Site Stony Brook New York 11794 Not yet recruiting
Research Site The Bronx New York 10451 Recruiting
Research Site Asheville North Carolina 28803 Recruiting
Research Site Chapel Hill North Carolina 27599 Recruiting
Research Site Charlotte North Carolina 28204 Not yet recruiting
Research Site Charlotte North Carolina 28262 Not yet recruiting
Research Site Durham North Carolina 27701 Recruiting
Research Site Durham North Carolina 27705 Recruiting
Research Site Greensboro North Carolina 27401 Not yet recruiting
Research Site Greensboro North Carolina 27408 Withdrawn
Research Site Lenoir North Carolina 28645 Not yet recruiting
Research Site Monroe North Carolina 28112 Recruiting
Research Site Morehead City North Carolina 28557 Recruiting
Research Site Morganton North Carolina 28655 Recruiting
Research Site New Bern North Carolina 28562 Recruiting
Research Site Wilmington North Carolina 28401 Recruiting
Research Site Winston-Salem North Carolina 27157 Recruiting
Research Site Fargo North Dakota 58104 Recruiting
Research Site Cincinnati Ohio 45220 Recruiting
Research Site Columbus Ohio 43213 Recruiting
Research Site Dublin Ohio 43016 Withdrawn
Research Site Lima Ohio 45801 Recruiting
Research Site Maumee Ohio 43537 Recruiting
Research Site Munroe Falls Ohio 44262 Suspended
Research Site Norman Oklahoma 73069 Suspended
Research Site Oklahoma City Oklahoma 73134 Recruiting
Research Site Portland Oregon 97210 Withdrawn
Research Site Camp Hill Pennsylvania 17011 Recruiting
Research Site Duncansville Pennsylvania 16635 Suspended
Research Site Horsham Pennsylvania 19044 Suspended
Research Site Philadelphia Pennsylvania 19107 Not yet recruiting
Research Site Philadelphia Pennsylvania 19114 Recruiting
Research Site Pittsburgh Pennsylvania 15212 Not yet recruiting
Research Site Smithfield Pennsylvania 15478 Recruiting
Research Site West Chester Pennsylvania 19380 Recruiting
Research Site Wilkes-Barre Pennsylvania 18711 Withdrawn
Research Site Yardley Pennsylvania 19067 Recruiting
Research Site Providence Rhode Island 02908 Recruiting
Research Site Charleston South Carolina 29402 Recruiting
Research Site Fort Mill South Carolina 29707 Recruiting
Research Site Mauldin South Carolina 29662 Recruiting
Research Site Myrtle Beach South Carolina 29572 Suspended
Research Site North Charleston South Carolina 29405 Recruiting
Research Site North Charleston South Carolina 29406 Suspended
Research Site Rapid City South Dakota 57701 Recruiting
Research Site Chattanooga Tennessee 37404 Recruiting
Research Site Chattanooga Tennessee 37421 Recruiting
Research Site Elizabethton Tennessee 37643 Withdrawn
Research Site Greeneville Tennessee 37745 Not yet recruiting
Research Site Knoxville Tennessee 37849 Suspended
Research Site Knoxville Tennessee 37909 Not yet recruiting
Research Site Knoxville Tennessee 37912 Recruiting
Research Site Knoxville Tennessee 37938 Recruiting
Research Site Memphis Tennessee 38119 Recruiting
Research Site Memphis Tennessee 38128 Recruiting
Research Site Morristown Tennessee 37813 Recruiting
Research Site Nashville Tennessee 37232 Not yet recruiting
Research Site Tullahoma Tennessee 37388 Recruiting
Research Site Amarillo Texas 79106 Recruiting
Research Site Beaumont Texas 77706 Recruiting
Research Site Brownsville Texas 78526 Recruiting
Research Site Corpus Christi Texas 78404 Recruiting
Research Site Dallas Texas 75216 Recruiting
Research Site Dallas Texas 75234 Recruiting
Research Site Dallas Texas 75246 Recruiting
Research Site Dallas Texas 75390 Not yet recruiting
Research Site DeSoto Texas 75115 Recruiting
Research Site El Paso Texas 79902 Suspended
Research Site El Paso Texas 79905 Recruiting
Research Site Euless Texas 76040 Recruiting
Research Site Houston Texas 77002 Recruiting
Research Site Houston Texas 77025 Not yet recruiting
Research Site Houston Texas 77034 Recruiting
Research Site Houston Texas 77043 Recruiting
Research Site Houston Texas 77087 Recruiting
Research Site Humble Texas 77338 Recruiting
Research Site Irving Texas 75061 Recruiting
Research Site Katy Texas 77450 Terminated
Research Site Kingwood Texas 77339 Recruiting
Research Site Kingwood Texas 77345 Recruiting
Research Site McAllen Texas 78503 Recruiting
Research Site McKinney Texas 75069 Recruiting
Research Site Mesquite Texas 75149 Recruiting
Research Site Odessa Texas 79761 Recruiting
Research Site Paris Texas 75462 Recruiting
Research Site Pearland Texas 77584 Withdrawn
Research Site Pharr Texas 78577 Recruiting
Research Site Plano Texas 75093 Recruiting
Research Site San Antonio Texas 78207 Recruiting
Research Site San Antonio Texas 78212 Recruiting
Research Site Sugar Land Texas 77478 Recruiting
Research Site Sugar Land Texas 77479 Recruiting
Research Site Temple Texas 76508 Recruiting
Research Site Tomball Texas 77375 Recruiting
Research Site Tyler Texas 75701 Recruiting
Research Site Victoria Texas 77901 Recruiting
Research Site Bountiful Utah 84010 Recruiting
Research Site Ogden Utah 84404 Withdrawn
Research Site Ogden Utah 84405 Recruiting
Research Site Roy Utah 84067 Withdrawn
Research Site Salt Lake City Utah 84124 Withdrawn
Research Site Salt Lake City Utah 84148 Withdrawn
Research Site White River Junction Vermont 05001 Recruiting
Research Site Charlottesville Virginia 22911 Withdrawn
Research Site Fairfax Virginia 22031 Recruiting
Research Site Falls Church Virginia 22042 Recruiting
Research Site Henrico Virginia 23229 Withdrawn
Research Site Hopewell Virginia 23860 Recruiting
Research Site Manassas Virginia 20109 Recruiting
Research Site Manassas Virginia 20110 Recruiting
Research Site Newport News Virginia 23606 Recruiting
Research Site Norfolk Virginia 23504 Recruiting
Research Site Richmond Virginia 23219 Recruiting
Research Site Suffolk Virginia 23435 Terminated
Research Site Puyallup Washington 98372 Not yet recruiting
Research Site Redmond Washington 98052 Recruiting
Research Site Renton Washington 98057 Recruiting
Research Site Seattle Washington 98122 Recruiting
Research Site Tacoma Washington 98405 Recruiting
Research Site Morgantown West Virginia 26505 Recruiting
Research Site Madison Wisconsin 53792 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1062 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07000357, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 23, 2026 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07000357 live on ClinicalTrials.gov.

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