Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

ClinicalTrials.gov ID: NCT07001800

Public ClinicalTrials.gov record NCT07001800. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 11:01 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2b/3, Randomized, Double-Blinded, Placebo Controlled Study ChecKing the Efficacy and Safety of ATAciguat to Slow the Progression of VaLvular DYsfunction in Participants With Moderate Calcific Aortic Valve STenosis

Study identification

NCT ID: NCT07001800
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Kardigan, Inc.; Industry
Enrollment: 1,276 participants

Conditions and interventions

Conditions

Moderate Aortic Valve Stenosis

Interventions

Ataciguat Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 50 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 26, 2025
Primary completion: Aug 30, 2028
Completion: Sep 29, 2030
Last update posted: May 5, 2026

2025 – 2030

United States locations

U.S. sites: 66
U.S. states: 24
U.S. cities: 61

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham (UAB) - Medical Center	Birmingham	Alabama	35233	Recruiting
Heart Center Research LLC	Huntsville	Alabama	35801	Recruiting
Onyx Clinical Research - Peoria	Peoria	Arizona	85381	Not yet recruiting
Mayo Clinic - Phoenix	Phoenix	Arizona	85259	Not yet recruiting
National Heart Institute	Beverly Hills	California	90211	Recruiting
UCLA Ronald Reagan Medical Center	Los Angeles	California	90095	Not yet recruiting
Hoag Memorial Hospital Presbyterian	Newport Beach	California	92663	Recruiting
Profound Research LLC at Southern California Heart Specialists	Pasadena	California	91105	Recruiting
University of California, San Francisco (UCSF) - Medical Center	San Francisco	California	94143	Recruiting
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center	Torrance	California	90502	Recruiting
HCA Florida - JFK Hospital	Atlantis	Florida	33462	Recruiting
New Generation of Medical Research	Hialeah	Florida	33016	Recruiting
Memorial Healthcare System	Hollywood	Florida	33021	Not yet recruiting
Jacksonville Center for Clinical Research	Jacksonville	Florida	32216	Recruiting
University of Miami	Miami	Florida	33136	Not yet recruiting
New Generation of Medical Research - Naples	Naples	Florida	34116	Recruiting
Flourish Research - St. Augustine	Saint Augustine	Florida	32086	Recruiting
Sarasota Memorial Hospital	Sarasota	Florida	34239	Recruiting
University of South Florida	Tampa	Florida	33606	Recruiting
Wellstar Kennestone Hospital	Marietta	Georgia	30060	Not yet recruiting
Northwestern University The Feinberg School of Medicine	Chicago	Illinois	60611	Recruiting
Ascension Heart and Vascular/Alexian Brothers Heart & Vascular Institute	Elk Grove Village	Illinois	60007	Not yet recruiting
NorthShore University Health System	Glenview	Illinois	60026	Recruiting
Riverside Medical Center - Illinois	Kankakee	Illinois	60901	Not yet recruiting
Midwest Cardiovascular Institute	Naperville	Illinois	60540	Recruiting
Methodist Medical Center of Illinois	Peoria	Illinois	61636	Not yet recruiting
Midwest Cardiovascular Research and Education Foundation	Elkhart	Indiana	46514	Not yet recruiting
University of Louisville Health	Louisville	Kentucky	40202	Recruiting
University of Maryland Medical Center	Baltimore	Maryland	21201	Not yet recruiting
Johns Hopkins University School of Medicine	Baltimore	Maryland	21287	Not yet recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Brigham and Women's Hospital	Boston	Massachusetts	02115	Recruiting
Corewell Health	Royal Oak	Michigan	48073	Recruiting
Henry Ford Hospital	West Bloomfield	Michigan	48322	Recruiting
M Health Fairview St. John's Hospital	Maplewood	Minnesota	55109	Not yet recruiting
Mayo Clinic - Rochester	Rochester	Minnesota	55905	Recruiting
Washington University	St Louis	Missouri	63110	Recruiting
Deborah Heart and Lung Center	Browns Mills	New Jersey	08015	Not yet recruiting
Virtua Our Lady of Lourdes Hospital	Camden	New Jersey	08103	Not yet recruiting
Atlantic Health System - Morristown Medical Center	Morristown	New Jersey	85831	Not yet recruiting
Inspira Medical Centers	Mullica Hill	New Jersey	08062	Not yet recruiting
Inspira Medical Center of Vineland	Vineland	New Jersey	08302	Not yet recruiting
Albany Medical Center	Albany	New York	12208	Recruiting
University of Buffalo	Buffalo	New York	14203	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
Duke University School of Medicine	Durham	North Carolina	27710	Recruiting
Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health	Greensboro	North Carolina	27401	Recruiting
Sanford Fargo	Fargo	North Dakota	58122	Recruiting
The Lindner Center for Research and Education at The Christ Hospital	Cincinnati	Ohio	45219	Recruiting
Bethesda North Hospital, TriHealth, Inc	Cincinnati	Ohio	45242	Not yet recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
ProMedica Toledo Hospital	Toledo	Ohio	43606	Not yet recruiting
Ascension St. John Hospital	Tulsa	Oklahoma	74104	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15213	Not yet recruiting
OnSite Clinical Solutions, LLC - Rock Hill	Rock Hill	South Carolina	29732	Recruiting
TriStar Centennial Medical Center	Nashville	Tennessee	37203	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
St. David's Heart and Vascular dba Austin Heart - Main Office	Austin	Texas	78705	Recruiting
Methodist Dallas Medical Center	Dallas	Texas	75203	Not yet recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
University of Texas Medical Branch - Galveston	Houston	Texas	77555	Not yet recruiting
Baylor Scott and White - The Heart Hospital Baylor Plano	Plano	Texas	75093	Recruiting
Methodist Hospital - San Antonio	San Antonio	Texas	78229	Recruiting
Houston Methodist Sugar Land Hospital	Sugar Land	Texas	77479	Not yet recruiting
University of Utah Hospital & Clinics	Salt Lake City	Utah	84112	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07001800, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07001800 live on ClinicalTrials.gov.

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