ClinicalTrials.gov record
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
ClinicalTrials.gov ID: NCT07028853
Public ClinicalTrials.gov record NCT07028853. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 7:33 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Mevrometostat (PF-06821497) With Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer (MEVPRO-3)
Study identification
- NCT ID
- NCT07028853
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 1,000 participants
Conditions and interventions
Conditions
Interventions
- Enzalutamide Drug
- Mevrometostat Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 27, 2025
- Primary completion
- Sep 11, 2028
- Completion
- Dec 7, 2034
- Last update posted
- May 4, 2026
2025 – 2034
United States locations
- U.S. sites
- 94
- U.S. states
- 19
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clearview Cancer Institute (Crestwood) | Huntsville | Alabama | 35801 | Not yet recruiting |
| Clearview Cancer Institute | Huntsville | Alabama | 35805 | Not yet recruiting |
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | Recruiting |
| Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | Recruiting |
| Ironwood Cancer & Research Centers | Glendale | Arizona | 85306 | Recruiting |
| Ironwood Cancer & Research Centers | Goodyear | Arizona | 85395 | Recruiting |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | Recruiting |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | Recruiting |
| Ironwood Cancer & Research Centers | Phoenix | Arizona | 85028 | Recruiting |
| Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | Recruiting |
| Highlands Oncology Group, PA | Fayetteville | Arkansas | 72703 | Recruiting |
| Highlands Oncology Group, PA | Rogers | Arkansas | 72758 | Recruiting |
| Highlands Oncology Group, PA | Springdale | Arkansas | 72762 | Recruiting |
| UCLA Hematology/Oncology - Alhambra | Alhambra | California | 91801 | Recruiting |
| UCLA Hematology/Oncology - Atascadero | Atascadero | California | 93422 | Recruiting |
| Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location) | Beverly Hills | California | 90211 | Recruiting |
| Cedars-Sinai Cancer Beverly Hills | Beverly Hills | California | 90211 | Recruiting |
| UCLA Hematology/Oncology - Beverly Hills | Beverly Hills | California | 90212 | Recruiting |
| UCLA Hematology/Oncology - Burbank | Burbank | California | 91505 | Recruiting |
| UCLA Hematology/Oncology - Encino | Encino | California | 91436 | Recruiting |
| UCLA Hematology/Oncology - Irvine | Irvine | California | 92604 | Recruiting |
| UCLA Hematology/Oncology - Laguna Hills | Laguna Hills | California | 92653 | Recruiting |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| Ronald Reagan UCLA Medical Center - Drug Information Center | Los Angeles | California | 90095 | Recruiting |
| UCLA Department of Medicine - Hematology/Oncology | Los Angeles | California | 90095 | Recruiting |
| UCLA Hematology/Oncology | Los Angeles | California | 90095 | Recruiting |
| UCLA Hematology/Oncology - Marina del Rey | Marina del Rey | California | 90292 | Recruiting |
| UCLA Hematology/Oncology - Pasadena | Pasadena | California | 91105 | Recruiting |
| UCLA Hematology/Oncology - Porter Ranch | Porter Ranch | California | 91326 | Recruiting |
| UCLA Hematology/Oncology - San Luis Obispo | San Luis Obispo | California | 93401 | Recruiting |
| UCLA Hematology/Oncology - Santa Barbara | Santa Barbara | California | 93101 | Recruiting |
| UCLA Hematology/Oncology- Santa Monica | Santa Monica | California | 90404 | Recruiting |
| UCLA Hematology/Oncology - Torrance | Torrance | California | 90505 | Recruiting |
| UCLA Hematology/Oncology - Santa Clarita | Valencia | California | 91355 | Recruiting |
| UCLA Hematology/Oncology - Ventura | Ventura | California | 93003 | Recruiting |
| UCLA Hematology/Oncology - Westlake | Westlake Village | California | 91361 | Recruiting |
| AdventHealth Medical Group Urology of Denver | Denver | Colorado | 80210 | Recruiting |
| Cancer Care Specialists of Illinois | Decatur | Illinois | 62526 | Recruiting |
| Cancer Care Specialists of Illinois | O'Fallon | Illinois | 62269 | Recruiting |
| Michigan Institute of Urology, PC | Troy | Michigan | 48084 | Not yet recruiting |
| MSK Basking Ridge | Basking Ridge | New Jersey | 07920 | Not yet recruiting |
| MSK Monmouth | Middletown | New Jersey | 07748 | Not yet recruiting |
| MSK Bergen | Montvale | New Jersey | 07645 | Not yet recruiting |
| MSK Commack | Commack | New York | 11725 | Not yet recruiting |
| MSKCC-Westchester (500 Westchester Ave.) | Harrison | New York | 10604 | Not yet recruiting |
| Memorial Sloan Kettering Cancer Center (IDS Pharmacy) | Long Island City | New York | 11101 | Not yet recruiting |
| Evelyn H. Lauder Breast and Imaging Center (BAIC). | New York | New York | 10065 | Not yet recruiting |
| Memorial Sloan Kettering Cancer Center - Main Campus | New York | New York | 10065 | Not yet recruiting |
| Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Not yet recruiting |
| University of Rochester Medical Center | Rochester | New York | 14642 | Recruiting |
| University of Rochester, Cancer Center Pharmacy (Investigational Product) | Rochester | New York | 14642 | Recruiting |
| Montefiore Einstein Comprehensive Cancer Center | The Bronx | New York | 10461 | Recruiting |
| Montefiore Medical Center- Montefiore Medical Park | The Bronx | New York | 10461 | Recruiting |
| MSK Nassau. | Uniondale | New York | 11553 | Not yet recruiting |
| Duke Cancer Center Cary | Cary | North Carolina | 27518 | Not yet recruiting |
| Duke University Medical Center (location of scans) | Durham | North Carolina | 27710 | Not yet recruiting |
| Duke University Medical Center - Duke Cancer Center | Durham | North Carolina | 27710 | Not yet recruiting |
| Duke University Medical Center - Duke University Hospital (location of scans) | Durham | North Carolina | 27710 | Not yet recruiting |
| Duke University | Durham | North Carolina | 27713 | Not yet recruiting |
| Duke Cancer Center Raleigh | Raleigh | North Carolina | 27609 | Not yet recruiting |
| Duke Raleigh Hospital | Raleigh | North Carolina | 27609 | Not yet recruiting |
| Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines) | Raleigh | North Carolina | 27609 | Not yet recruiting |
| University Hospitals Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | Recruiting |
| TriState Urologic Services PSC Inc. dba The Urology Group | Cincinnati | Ohio | 45212 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| University Hospitals Seidman Cancer Center at UH Mentor Health Center | Mentor | Ohio | 44060 | Recruiting |
| UH Minoff Health Center at Chagrin Highlands | Orange | Ohio | 44122 | Recruiting |
| The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists | Lancaster | Pennsylvania | 17604 | Recruiting |
| Grand Strand Medical Center | Myrtle Beach | South Carolina | 295724607 | Recruiting |
| Carolina Urologic Research Center, LLC | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Parkway Surgery Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| The West Clinic, PLLC dba West Cancer Center | Germantown | Tennessee | 38138 | Recruiting |
| Urology Associates, P.C. | Nashville | Tennessee | 37209 | Recruiting |
| University of Texas Southwestern Medical Center - Simmons Cancer Center | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Simmons Cancer Center - Redbird | Dallas | Texas | 75237 | Recruiting |
| University of Texas Southwestern Medical Center-Zale Lipshy University Hospital | Dallas | Texas | 75390 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| University of Texas Southwestern Simmons Cancer Center - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | Recruiting |
| University of Texas Southwestern Simmons Cancer Center - Richardson/Plano | Richardson | Texas | 75080 | Recruiting |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | Recruiting |
| Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | Recruiting |
| Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | Recruiting |
| Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| Blue Ridge Cancer Care | Salem | Virginia | 24153 | Recruiting |
| Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | Recruiting |
| Northwest Medical Specialties, PLLC | Bonney Lake | Washington | 98391 | Recruiting |
| Northwest Medical Specialties, PLLC | Federal Way | Washington | 98003 | Recruiting |
| Northwest Medical Specialties, PLLC | Gig Harbor | Washington | 98332 | Recruiting |
| Northwest Medical Specialties, PLLC | Puyallup | Washington | 98373 | Recruiting |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | Recruiting |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | Recruiting |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 206 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07028853, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07028853 live on ClinicalTrials.gov.