This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

ClinicalTrials.gov ID: NCT07028853

Public ClinicalTrials.gov record NCT07028853. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 4:53 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will explore whether a combination of the investigational drug mevrometostat (PF-06821497) and enzalutamide will work better than taking enzalutamide alone in participants with mCSPC who are ARPI naïve and have not yet received chemotherapy in the mCSPC setting.

Study identification

NCT ID: NCT07028853
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Pfizer; Industry
Enrollment: 1,000 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: Male
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 27, 2025
Primary completion: Sep 11, 2028
Completion: Dec 7, 2034
Last update posted: Aug 13, 2026

2025 – 2034

United States locations

U.S. sites: 124
U.S. states: 21
U.S. cities: 90

Facility	City	State	ZIP	Site status
Clearview Cancer Institute (Crestwood)	Huntsville	Alabama	35801	Recruiting
Clearview Cancer Institute	Huntsville	Alabama	35805	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Chandler	Arizona	85224	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Gilbert	Arizona	85297	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Glendale	Arizona	85306	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Goodyear	Arizona	85395	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Mesa	Arizona	85202	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Mesa	Arizona	85206	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Phoenix	Arizona	85028	Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers	Scottsdale	Arizona	85260	Recruiting
Highlands Oncology Group, PA	Fayetteville	Arkansas	72703	Recruiting
Highlands Oncology Group, PA	Rogers	Arkansas	72758	Recruiting
Highlands Oncology Group, PA	Springdale	Arkansas	72762	Recruiting
UCLA Hematology/Oncology - Alhambra	Alhambra	California	91801	Recruiting
UCLA Hematology/Oncology - Atascadero	Atascadero	California	93422	Recruiting
Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location)	Beverly Hills	California	90211	Recruiting
Cedars-Sinai Cancer Beverly Hills	Beverly Hills	California	90211	Recruiting
UCLA Hematology/Oncology - Beverly Hills	Beverly Hills	California	90212	Recruiting
UCLA Hematology/Oncology - Burbank	Burbank	California	91505	Recruiting
UCLA Hematology/Oncology - Encino	Encino	California	91436	Recruiting
UCLA Hematology/Oncology - Irvine	Irvine	California	92604	Recruiting
UCLA Hematology/Oncology - Laguna Hills	Laguna Hills	California	92653	Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Ronald Reagan UCLA Medical Center - Drug Information Center	Los Angeles	California	90095	Recruiting
UCLA Department of Medicine - Hematology/Oncology	Los Angeles	California	90095	Recruiting
UCLA Hematology/Oncology	Los Angeles	California	90095	Recruiting
UCLA Hematology/Oncology - Marina del Rey	Marina del Rey	California	90292	Recruiting
UCLA Hematology/Oncology - Pasadena	Pasadena	California	91105	Recruiting
UCLA Hematology/Oncology - Porter Ranch	Porter Ranch	California	91326	Recruiting
UCLA Hematology/Oncology - San Luis Obispo	San Luis Obispo	California	93401	Recruiting
UCLA Hematology/Oncology - Santa Barbara	Santa Barbara	California	93101	Recruiting
UCLA Hematology/Oncology- Santa Monica	Santa Monica	California	90404	Recruiting
UCLA Hematology/Oncology - Torrance	Torrance	California	90505	Recruiting
UCLA Hematology/Oncology - Santa Clarita	Valencia	California	91355	Recruiting
UCLA Hematology/Oncology - Ventura	Ventura	California	93003	Recruiting
UCLA Hematology/Oncology - Westlake	Westlake Village	California	91361	Recruiting
AdventHealth Medical Group Urology of Denver	Denver	Colorado	80210	Recruiting
Advanced Urology Institute, LLC	Largo	Florida	33771	Recruiting
Tennessee Oncology, PLLC - Dalton	Dalton	Georgia	30720	Recruiting
Tennessee Oncology, PLLC - Ringgold	Ringgold	Georgia	30736	Recruiting
Associated Urological Specialists - Chicago Ridge	Chicago Ridge	Illinois	60415	Recruiting
Cancer Care Specialists of Illinois	Decatur	Illinois	62526	Recruiting
Cancer Care Specialists of Illinois	O'Fallon	Illinois	62269	Recruiting
Michigan Institute of Urology, PC	Troy	Michigan	48084	Recruiting
MSK Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
MSK Monmouth	Middletown	New Jersey	07748	Recruiting
MSK Bergen	Montvale	New Jersey	07645	Recruiting
MSK Commack	Commack	New York	11725	Recruiting
MSKCC-Westchester (500 Westchester Ave.)	Harrison	New York	10604	Recruiting
Memorial Sloan Kettering Cancer Center (IDS Pharmacy)	Long Island City	New York	11101	Recruiting
Evelyn H. Lauder Breast and Imaging Center (BAIC).	New York	New York	10065	Recruiting
Memorial Sloan Kettering Cancer Center - Main Campus	New York	New York	10065	Recruiting
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester Medical Center	Rochester	New York	14642	Recruiting
University of Rochester, Cancer Center Pharmacy (Investigational Product)	Rochester	New York	14642	Recruiting
Integrated Medical Professionals	Seaford	New York	11783	Recruiting
Montefiore Einstein Comprehensive Cancer Center	The Bronx	New York	10461	Recruiting
Montefiore Medical Center- Montefiore Medical Park	The Bronx	New York	10461	Recruiting
MSK Nassau.	Uniondale	New York	11553	Recruiting
Duke Cancer Center Cary	Cary	North Carolina	27518	Recruiting
Duke University Medical Center (location of scans)	Durham	North Carolina	27710	Recruiting
Duke University Medical Center - Duke Cancer Center	Durham	North Carolina	27710	Recruiting
Duke University Medical Center - Duke University Hospital (location of scans)	Durham	North Carolina	27710	Recruiting
Duke University	Durham	North Carolina	27713	Recruiting
Duke Cancer Center Raleigh	Raleigh	North Carolina	27609	Recruiting
Duke Raleigh Hospital	Raleigh	North Carolina	27609	Recruiting
Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines)	Raleigh	North Carolina	27609	Recruiting
University Hospitals Seidman Cancer Center at UH Avon Health Center	Avon	Ohio	44011	Recruiting
TriState Urologic Services PSC Inc. dba The Urology Group	Cincinnati	Ohio	45212	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
University Hospitals Seidman Cancer Center at UH Mentor Health Center	Mentor	Ohio	44060	Recruiting
UH Minoff Health Center at Chagrin Highlands	Orange	Ohio	44122	Recruiting
MidLantic urology	Bala-Cynwyd	Pennsylvania	19004	Recruiting
The Centers for Advanced Urology d/b/a Keystone Urology Specialist	Lancaster	Pennsylvania	17604	Recruiting
Grand Strand Medical Center	Myrtle Beach	South Carolina	295724607	Recruiting
Carolina Urologic Research Center, LLC	Myrtle Beach	South Carolina	29572	Recruiting
Parkway Surgery Center	Myrtle Beach	South Carolina	29572	Recruiting
Tennessee Oncology, PLLC - Chattanooga Downtown	Chattanooga	Tennessee	37403	Recruiting
Tennessee Oncology PLLC	Chattanooga	Tennessee	37404	Recruiting
Tennessee Oncology, PLLC - Chattanooga Med Park II	Chattanooga	Tennessee	37404	Recruiting
Tennessee Oncology, PLLC - Chattanooga Memorial	Chattanooga	Tennessee	37404	Recruiting
Tennessee Oncology, PLLC - Chattanooga East	Chattanooga	Tennessee	37421	Recruiting
Tennessee Oncology, PLLC - Cleveland	Cleveland	Tennessee	37311	Recruiting
Tennessee Oncology, PLLC - Cookeville	Cookeville	Tennessee	38501	Recruiting
Tennessee Oncology, PLLC - Dickson	Dickson	Tennessee	37055	Recruiting
Tennessee Oncology, PLLC - Franklin	Franklin	Tennessee	37067	Recruiting
Tennessee Oncology, PLLC - Gallatin	Gallatin	Tennessee	37066	Recruiting
The West Clinic, PLLC dba West Cancer Center	Germantown	Tennessee	38138	Recruiting
Tennessee Oncology Hendersonville	Hendersonville	Tennessee	37075	Recruiting
Tennessee Oncology, PLLC - Lebanon	Lebanon	Tennessee	37090	Recruiting
Tennessee Oncology, PLLC - Mount Juliet	Mount Juliet	Tennessee	37122	Recruiting
Tennessee Oncology, PLLC - Murfreesboro	Murfreesboro	Tennessee	37129	Recruiting
Tennessee Oncology, PLLC - Investigational Drug Services	Nashville	Tennessee	37203	Recruiting
Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Medical Oncology & Hematology	Nashville	Tennessee	37203	Recruiting
Tennessee Oncology, PLLC - Nashville Saint Thomas West	Nashville	Tennessee	37205	Recruiting
Tennessee Oncology, PLLC - Nashville Skyline	Nashville	Tennessee	37207	Recruiting
Urology Associates, P.C.	Nashville	Tennessee	37209	Recruiting
Tennessee Oncology, PLLC - Nashville Southern Hills	Nashville	Tennessee	37211	Recruiting
Tennessee Oncology, PLLC - Shelbyville	Shelbyville	Tennessee	37160	Recruiting
Tennessee Oncology, PLLC - Smyrna	Smyrna	Tennessee	37167	Recruiting
University of Texas Southwestern Medical Center - Simmons Cancer Center	Dallas	Texas	75235	Recruiting
University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital	Dallas	Texas	75235	Recruiting
University of Texas Southwestern Simmons Cancer Center - Redbird	Dallas	Texas	75237	Recruiting
University of Texas Southwestern Medical Center-Zale Lipshy University Hospital	Dallas	Texas	75390	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
University of Texas Southwestern Simmons Cancer Center - Fort Worth	Fort Worth	Texas	76104	Recruiting
US Oncology Investigational Product Center (IPC)	Irving	Texas	75063	Recruiting
University of Texas Southwestern Simmons Cancer Center - Richardson/Plano	Richardson	Texas	75080	Recruiting
Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Blue Ridge Cancer Care	Blacksburg	Virginia	24060	Recruiting
University of Virginia Comprehensive Cancer Center	Charlottesville	Virginia	22903	Not yet recruiting
University of Virginia	Charlottesville	Virginia	22908	Not yet recruiting
UVA Health Cancer Care Pantops	Charlottesville	Virginia	22911	Not yet recruiting
Blue Ridge Cancer Care	Low Moor	Virginia	24457	Recruiting
Blue Ridge Cancer Care	Roanoke	Virginia	24014	Recruiting
Blue Ridge Cancer Care	Salem	Virginia	24153	Recruiting
Blue Ridge Cancer Care	Wytheville	Virginia	24382	Recruiting
Northwest Medical Specialties, PLLC	Bonney Lake	Washington	98391	Recruiting
Northwest Medical Specialties, PLLC	Federal Way	Washington	98003	Recruiting
Northwest Medical Specialties, PLLC	Gig Harbor	Washington	98332	Recruiting
Northwest Medical Specialties, PLLC	Puyallup	Washington	98373	Recruiting
Northwest Medical Specialties, PLLC	Tacoma	Washington	98405	Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center	Madison	Wisconsin	53718	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 213 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07028853, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 13, 2026 · Synced Sep 2, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07028853 live on ClinicalTrials.gov.

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