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Recruiting Phase 3 Interventional

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

ClinicalTrials.gov ID: NCT07037433

Public ClinicalTrials.gov record NCT07037433. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:45 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Study identification

NCT ID
NCT07037433
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Amgen
Industry
Enrollment
12,800 participants

Conditions and interventions

Interventions

  • Maridebart Cafraglutide Drug
  • Placebo Drug

Drug

Eligibility (public fields only)

Age range
45 Years to 99 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 24, 2025
Primary completion
Jun 29, 2028
Completion
Sep 28, 2030
Last update posted
Apr 23, 2026

2025 – 2030

United States locations

U.S. sites
139
U.S. states
36
U.S. cities
119
Facility City State ZIP Site status
Alliance For Multispecialty Research - Daphne Daphne Alabama 36526 Recruiting
Eastern Shore Research Institute Fairhope Alabama 36532 Recruiting
Heart Center Research LLC Huntsville Alabama 35801 Recruiting
Mobile Heart Specialists PC Mobile Alabama 36608 Recruiting
Syed Research Consultants LLC Sheffield Alabama 35660 Recruiting
Synexus Clinical Research US, Inc. Phoenix Arizona 85020 Recruiting
Medical Advancement Centers of Arizona Phoenix Arizona 85044 Recruiting
Valley Clinical Trials, LLC dba Flourish Research Covina California 91723 Recruiting
Velocity Clinical Research- Huntington Park Huntington Park California 90255 Recruiting
Velocity Clinical Research- Los Angeles La Mesa California 91942 Completed
Orange County Research Center Lake Forest California 92630 Recruiting
Biopharma Informatic - The Cardiovascular Center Redding California 96001 Recruiting
Acclaim Clinical Research San Diego California 92120 Recruiting
Encompass Clinical Research Spring Valley California 91978 Recruiting
Diablo Clinical Research Walnut Creek California 94598 Recruiting
Focus Clinical Research West Hills California 91307 Recruiting
Family Practice Associates Wilmington Delaware 19805 Recruiting
Excel Medical Clinical Trials Boca Raton Florida 33434 Recruiting
Velocity Clinical Research - New Smyrna Beach Edgewater Florida 32132 Recruiting
Alliance for Multispecialty Research - Fort Myers Fort Myers Florida 33912 Recruiting
Indago Research and Health Center Hialeah Florida 33012 Recruiting
Elite Cardiac Research Center LLC Hialeah Florida 33013 Recruiting
Elite Clinical Research Hialeah Florida 33018 Recruiting
Zenith Clinical Research Hollywood Florida 33021 Recruiting
Encore Medical Research LLC Hollywood Florida 33024 Recruiting
East Coast Institute for Research, LLC Jacksonville Florida 32216 Recruiting
Clinical Research of Central Florida Lakeland Florida 33805 Recruiting
South Florida Clinical Research Margate Florida 33063 Recruiting
Finlay Medical Research Miami Florida 33126 Recruiting
Suncoast Research Group LLC Miami Florida 33135 Recruiting
New Horizon Research Center Miami Florida 33165 Recruiting
Panax Clinical Research Miami Lakes Florida 33014 Recruiting
San Marcus Research Clinic Inc Miami Lakes Florida 33014 Recruiting
West Orange Endocrinology Ocoee Florida 34761 Recruiting
Cardiology Partners Clinical Research Institute Palm Beach Gardens Florida 33410 Recruiting
Peace River Cardiovascular Center Port Charlotte Florida 33952 Recruiting
Progressive Medical Research Port Orange Florida 32127 Recruiting
Saint Johns Center for Clinical Research Saint Augustine Florida 32086 Recruiting
Intercoastal Medical Group Sarasota Florida 34239 Recruiting
Winter Haven Hospital Winter Haven Florida 33881 Recruiting
East Coast Institute for Research LLC at Canton Georgia Canton Georgia 30114 Recruiting
The Jones Center Clinical Research Macon Georgia 31210 Recruiting
Velocity Clinical Research - Savannah Savannah Georgia 31419 Recruiting
Velocity Clinical Research - Boise Meridian Idaho 83642 Recruiting
Endeavor Health-Northwest Community Healthcare Arlington Heights Illinois 60005 Recruiting
Eagle Clinical Research Chicago Illinois 60621 Recruiting
University of Chicago Chicago Illinois 60637 Recruiting
Alliance For Multispecialty Research - Oak Brook Oak Brook Illinois 60523 Recruiting
Prarie Education and Research Springfield Illinois 62701 Recruiting
Cardiovascular Research of Northwest Indiana LLC Munster Indiana 46321 Recruiting
Velocity Clinical Research - Valparaiso Valparaiso Indiana 46383 Recruiting
McFarland Clinic PC Ames Iowa 50010 Recruiting
Midwest Cardiovascular Research Foundation Davenport Iowa 52801 Recruiting
Cotton-ONeil Diabetes and Endocrinology Center Topeka Kansas 66606 Recruiting
Monroe Biomedical Research Louisville Kentucky 40213 Recruiting
Cardiovascular Associates Research, LLC Covington Louisiana 70433 Recruiting
Tandem Clinical Research - Marrero Marrero Louisiana 70072 Recruiting
Ascension Saint Agnes Heart Care Baltimore Maryland 21229 Recruiting
MD Medical Research Oxon Hill Maryland 20745 Recruiting
Velocity Clinical Research - Rockville Rockville Maryland 20854 Recruiting
Btc of New Bedford New Bedford Massachusetts 02740 Recruiting
Fairview Health Services M Health Fairview St Johns Hospital Maplewood Minnesota 55109 Recruiting
Minneapolis Heart Institute Foundation Minneapolis Minnesota 55407 Recruiting
Jackson Heart Clinic Jackson Mississippi 39216 Recruiting
Cardiology Associates of North Mississippi Tupelo Mississippi 38801 Recruiting
StudyMetrix Research City of Saint Peters Missouri 63303 Recruiting
Alliance for Multispecialty Research - Kansas City Kansas City Missouri 64114 Recruiting
Kansas City Veterans Affairs Medical Center Kansas City Missouri 64128 Recruiting
Saint Louis Heart and Vascular PC St Louis Missouri 63136 Recruiting
Bryan Heart Lincoln Nebraska 68506 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Primary Clinical Research Papillion Nebraska 68046 Recruiting
Excel Clinical Research Las Vegas Nevada 89109 Recruiting
Vector Clinical Trials Las Vegas Nevada 89128 Recruiting
CardioMetabolic Collaborative Clinic Somerset New Jersey 08873 Recruiting
Velocity Clinical Research - Binghamton Binghamton New York 13905 Recruiting
Hudson Valley Cardiovascular Practice PC Poughkeepsie New York 12601 Recruiting
Rochester Clinical Research Rochester New York 14609 Recruiting
Saratoga Clinical Research, LLC Saratoga Springs New York 12866 Recruiting
Southgate Medical Group West Seneca New York 14224 Recruiting
Novant Health Heart and Vascular Institute Charlotte North Carolina 28204 Recruiting
Velocity Clinical Research - Durham Durham North Carolina 27701 Recruiting
Moses H Cone Memorial Hospital Greensboro North Carolina 27401 Recruiting
Monroe Biomedical Research Monroe North Carolina 28112 Recruiting
West Clinical Research Morehead City North Carolina 28557 Recruiting
Burke Primary Care Family Practice Morganton North Carolina 28655 Recruiting
Accellacare of Raleigh Raleigh North Carolina 27609 Recruiting
Accellacare of Piedmont Healthcare Statesville North Carolina 28625 Recruiting
Brookview Hills Research Associates Llc Winston-Salem North Carolina 27103 Recruiting
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 Recruiting
Velocity Clinical Research - Cleveland Beachwood Ohio 44122 Recruiting
Aultman Hospital, Cardiovascular Consultants, Inc Canton Ohio 44710 Recruiting
Velocity Clinical Research - Auburn Cincinnati Ohio 45219 Recruiting
Endocrinology Associates Inc Columbus Ohio 43201 Recruiting
Nexgen Research Lima Ohio 45801 Recruiting
Alliance for Multispecialty Research - Norman Norman Oklahoma 73069 Recruiting
Heritage Valley Multispecialty Group Inc Beaver Pennsylvania 15009 Recruiting
Capital Area Research LLC Camp Hill Pennsylvania 17011 Recruiting
Abington Medical Specialists Horsham Pennsylvania 19044 Recruiting
Velocity Clinical Research - Providence East Greenwich Rhode Island 02818 Recruiting
Accellacare Charleston Mt. Pleasant South Carolina 29464 Recruiting
Monument Health Clinical Research Rapid City South Dakota 57701 Recruiting
Stern Cardiovascular Foundation Inc Germantown Tennessee 38138 Recruiting
Accellacare of Knoxville Knoxville Tennessee 37912 Recruiting
Cardiovascular Research of Knoxville North Knoxville Medical Center Powell Tennessee 37849 Recruiting
Tennessee Center for Clinical Trials Tullahoma Tennessee 37388 Recruiting
PharmaTex Research, LLC Amarillo Texas 79106 Recruiting
Austin Heart Austin Texas 78705 Recruiting
Velocity Clinical Research - Austin Austin Texas 78759 Recruiting
Thyroid Endocrinology and Diabetes Dallas Texas 75208 Recruiting
Soltero Cardiovascular Research Center Dallas Texas 75226 Recruiting
Zenos Clinical Research Dallas Texas 75230 Recruiting
Cedar Health Research, LLC Dallas Texas 75251 Recruiting
University of Texas Southwestern Medical Center Dallas Texas 75390 Recruiting
David Turbay, MD El Paso Texas 79905 Recruiting
Academy of Diabetes Thyroid and Endocrine El Paso Texas 79935 Recruiting
Biopharma Informatic, LLC Houston Texas 77043 Recruiting
Cardiovascular Specialists of Willowbrook Houston Texas 77070 Recruiting
PlanIt Research, PLLC Houston Texas 77079 Recruiting
Research Physicians Network, LLC Houston Texas 77089 Recruiting
Vital Heart and Vein Humble Texas 77338 Recruiting
Tcr Institute Llc Kingwood Texas 77339 Recruiting
Helium Research Group Lake Jackson Texas 77566 Recruiting
Epic Clinical Research Lewisville Texas 75057 Recruiting
Biopharma Informatic-McAllen McAllen Texas 78503 Recruiting
Southern Endocrinology Associates PA Mesquite Texas 75149 Recruiting
North Hills Medical Research North Richland Hills Texas 76180 Recruiting
Bandera Family Health Care San Antonio Texas 78249 Recruiting
Consano Clinical Research - Shavano Park Shavano Park Texas 78231 Recruiting
Sugar Lakes Family Practice Sugar Land Texas 77479 Recruiting
Wichita Falls Heart Clinic Wichita Falls Texas 76301 Recruiting
Boeson Research Provo Utah 84604 Recruiting
Velocity Clinical Research - Salt Lake City West Jordan Utah 84088 Recruiting
Inova Cardiology - Fairfax Fairfax Virginia 22031 Recruiting
Virginia Heart Falls Church Virginia 22042 Recruiting
VA Puget Sound Healthcare System Seattle Washington 98108 Recruiting
Velocity Clinical Research - Spokane Spokane Washington 99218 Recruiting
Vaught Neurological Services Crab Orchard West Virginia 25827 Recruiting
Aspirus Cardiovascular Associates Wausau Wisconsin 54401 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 620 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07037433, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 23, 2026 · Synced May 6, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07037433 live on ClinicalTrials.gov.

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