Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ClinicalTrials.gov ID: NCT07037459

Public ClinicalTrials.gov record NCT07037459. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 2:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Maridebart Cafraglutide on Mortality and Morbidity in Participants Living With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)

Study identification

NCT ID: NCT07037459
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Amgen; Industry
Enrollment: 5,056 participants

Conditions and interventions

Conditions

Interventions

Maridebart cafraglutide Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 99 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 24, 2025
Primary completion: Jun 29, 2028
Completion: Sep 28, 2030
Last update posted: May 4, 2026

2025 – 2030

United States locations

U.S. sites: 105
U.S. states: 30
U.S. cities: 97

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35205	Recruiting
SEC Clinical Research	Dothan	Alabama	36305	Recruiting
Eastern Shore Research Institute	Fairhope	Alabama	36532	Recruiting
Heart Center Research LLC	Huntsville	Alabama	35801-4317	Recruiting
HonorHealth	Phoenix	Arizona	85006	Recruiting
Medical Advancement Centers of Arizona	Phoenix	Arizona	85044	Recruiting
Pima Heart and Vascular Clinical Research	Tucson	Arizona	85704	Recruiting
Yuma Clinical Trials	Yuma	Arizona	85365	Recruiting
Arkansas Cardiology	Little Rock	Arkansas	72205	Recruiting
National Heart Institute	Beverly Hills	California	90211	Recruiting
Valley Clinical Trials, LLC dba Flourish Research	Covina	California	91723	Recruiting
National Institute of Clinical Research	Huntington Beach	California	92648	Recruiting
310 Clinical Research	Inglewood	California	90301	Recruiting
Radin Cardiovascular Medical Group	Newport Beach	California	92663	Recruiting
Valley Clinical Trials	Northridge	California	91325	Recruiting
University of California Irvine	Orange	California	92868	Recruiting
Empire Clinical Research	Pomona	California	91767	Recruiting
San Diego Cardiac Center	San Diego	California	92123	Recruiting
NorthBay Clinical Research LLC	Santa Rosa	California	95405	Recruiting
Manshadi Heart Institute	Stockton	California	95204	Recruiting
Cardiology Associates of Fairfield County PC	Stamford	Connecticut	06905	Recruiting
Orlando Heart and Vascular Institute	Altamonte Springs	Florida	32714	Recruiting
Excel Medical Clinical Trials	Boca Raton	Florida	33434	Recruiting
Cardiovascular and Vein Center of Florida	Bradenton	Florida	34209	Recruiting
Millennium Medical Research	Coral Gables	Florida	33134	Recruiting
Elite Cardiac Research Center LLC	Hialeah	Florida	33013	Recruiting
Encore Medical Research LLC	Hollywood	Florida	33024	Recruiting
Nature Coast Clinical Research	Inverness	Florida	34452	Recruiting
East Coast Institute for Research	Jacksonville	Florida	32216	Recruiting
First Coast Cardiovascular Institute PA	Jacksonville	Florida	32216	Recruiting
Jacksonville Center for Clinical Research	Jacksonville	Florida	32216	Recruiting
Clearwater Cardiovascular Consultants	Largo	Florida	33777	Recruiting
Ocala Cardiovascular Research	Ocala	Florida	34471	Recruiting
Orlando Health Heart Institute	Orlando	Florida	32806	Recruiting
Ormond Beach Clinical Research	Ormond Beach	Florida	32174	Recruiting
Broward Research Center	Pembroke Pines	Florida	33024	Recruiting
Ascension Sacred Heart	Pensacola	Florida	32504	Recruiting
Cardiovascular Center of Sarasota	Sarasota	Florida	34239	Recruiting
Cardiology Partners Clinical Research Institute	Wellington	Florida	33449	Recruiting
Guardian Research Organization LLC	Winter Park	Florida	32792	Recruiting
Privia Medical Group Georgia LLC	Peachtree City	Georgia	30269	Recruiting
High Desert Heart and Vascular	Meridian	Idaho	83642	Recruiting
Chicago Medical Research LLC	Hazel Crest	Illinois	60429	Recruiting
Midwest Cardiovascular Research And Education Foundation	Elkhart	Indiana	46514	Recruiting
Ascension Medical Group	Indianapolis	Indiana	46260	Recruiting
Cardiovascular Research of Northwest Indiana LLC	Munster	Indiana	46321	Recruiting
Reid Physician Associates	Richmond	Indiana	47374	Recruiting
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
Johnson County Clintrials	Lenexa	Kansas	66219	Recruiting
Kansas Nephrology Research Institute LLC	Wichita	Kansas	67214	Recruiting
The Research Group of Lexington LLC	Lexington	Kentucky	40503	Recruiting
Our Lady of the Lake Medical Center	Baton Rouge	Louisiana	70808	Recruiting
Louisiana Heart Center - Hammond	Covington	Louisiana	70433	Recruiting
Heart Clinic of Hammond	Hammond	Louisiana	70403	Recruiting
Northshore Heart and Vascular LLC	Mandeville	Louisiana	70448	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Metropolitan Cardiovascular Consultants LLC	Beltsville	Maryland	20705	Recruiting
Flourish Bowie	Bowie	Maryland	20715	Recruiting
Healthy Heart Cardiology	Grand Rapids	Michigan	49546	Recruiting
Advanced Cardiology Associates	Rochester Hills	Michigan	48307	Recruiting
Fairview Health Services M Health Fairview St Johns Hospital	Maplewood	Minnesota	55109	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Saint Luke's Hospital of Kansas City	Kansas City	Missouri	64111	Recruiting
Kalispell Regional Medical Center	Kalispell	Montana	59901	Recruiting
Bryan Heart	Lincoln	Nebraska	68506	Recruiting
Methodist Physicians Clinic Heart Consultants	Omaha	Nebraska	68114	Recruiting
Advanced Heart Care LLC	Bridgewater	New Jersey	08807	Recruiting
Virtua Health Incorporated	Marlton	New Jersey	08053	Recruiting
Saint Michaels Medical Center	Newark	New Jersey	07102	Recruiting
CardioMetabolic Collaborative Clinic	Somerset	New Jersey	08873	Recruiting
Capital Cardiology Associates	Albany	New York	12211	Recruiting
Icahn School of Medicine at Mount Sinai	New York	New York	10019	Recruiting
Hudson Valley Cardiovascular Practice PC	Poughkeepsie	New York	12601	Recruiting
Richmond University Medical Center	Staten Island	New York	10310	Recruiting
Duke University Health System	Durham	North Carolina	27719	Recruiting
Accellacare of Wilmington	Wilmington	North Carolina	28401	Recruiting
South Oklahoma Heart Research	Oklahoma City	Oklahoma	73135	Recruiting
Abington Medical Specialists	Horsham	Pennsylvania	19044	Recruiting
Monument Health Clinical Research	Rapid City	South Dakota	57701	Recruiting
Apex Research Foundation, LLC	Jackson	Tennessee	38301	Recruiting
The Jackson Clinic PA	Jackson	Tennessee	38305	Recruiting
Parkway Cardiology Associates	Oak Ridge	Tennessee	37830	Recruiting
Cardiovascular Research of Knoxville North Knoxville Medical Center	Powell	Tennessee	37849	Recruiting
Tennessee Center for Clinical Trials	Tullahoma	Tennessee	37388	Recruiting
PharmaTex Research, LLC	Amarillo	Texas	79106	Recruiting
Austin Heart	Austin	Texas	78705	Recruiting
Javara Research	Conroe	Texas	77384	Recruiting
Dallas Heart and Vascular Consultants	Duncanville	Texas	75137	Recruiting
David Turbay, MD	El Paso	Texas	79905	Recruiting
East Texas Cardiology PA	Houston	Texas	77002	Recruiting
Biopharma Informatic	Houston	Texas	77025	Recruiting
Biopharma Informatic, LLC	Houston	Texas	77043	Recruiting
Biopharma Informatic	Houston	Texas	77084	Recruiting
Vital Heart and Vein	Humble	Texas	77338	Recruiting
North Dallas Research Associates	McKinney	Texas	75069	Recruiting
Texas Institute of Cardiology	McKinney	Texas	75071	Recruiting
Sherman Clinical Research	Sherman	Texas	75092	Recruiting
Northwest Houston Clinical Research PLLC	Tomball	Texas	77375	Recruiting
Conquest Research, LLC	Arlington	Virginia	22205	Recruiting
Virginia Heart	Falls Church	Virginia	22042	Recruiting
Carient Heart and Vascular	Manassas	Virginia	20109	Recruiting
Roanoke Heart Institute PLC	Roanoke	Virginia	24014	Recruiting
Salem VA Medical Center	Salem	Virginia	24153	Recruiting
Pulse Heart Institute	Puyallup	Washington	98372	Recruiting
Advocate Aurora Saint Lukes Medical Center	Milwaukee	Wisconsin	53215	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 498 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07037459, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07037459 live on ClinicalTrials.gov.

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