Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

ClinicalTrials.gov ID: NCT07044336

Public ClinicalTrials.gov record NCT07044336. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 27, 2026, 1:07 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4 Selected Advanced/Metastatic Endometrial Cancer Who Progressed On or After Platinum Based Chemotherapy and Anti-PD-1/Anti-PD-L1 Therapy (Bluestar-Endometrial01)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a Phase III, 2-arm, randomized, open label, multicenter, global study assessing the efficacy and safety of puxitatug samrotecan compared to physician's choice of chemotherapy (doxorubicin or paclitaxel) in participants with B7-H4 selected advanced/metastatic EC that progressed following platinum based chemotherapy and anti-PD-1/anti-PD-L1 therapy.

Study identification

NCT ID: NCT07044336
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 800 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: Female
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 1, 2025 (Actual)
Primary completion: Oct 15, 2027 (Estimated)
Completion: Jul 17, 2029 (Estimated)
Last update posted: Jul 29, 2026

2025 – 2029

United States locations

U.S. sites: 69
U.S. states: 25
U.S. cities: 63

Facility	City	State	ZIP	Site status
Research Site	Tucson	Arizona	85719	Not yet recruiting
Research Site	La Jolla	California	92037	Recruiting
Research Site	Los Angeles	California	90095	Withdrawn
Research Site	Orange	California	92868	Recruiting
Research Site	Washington D.C.	District of Columbia	20016	Not yet recruiting
Research Site	Jupiter	Florida	33458	Recruiting
Research Site	Miami	Florida	33136	Not yet recruiting
Research Site	Miami	Florida	33176	Recruiting
Research Site	Miami Beach	Florida	33140	Recruiting
Research Site	New Port Richey	Florida	34655	Recruiting
Research Site	Orlando	Florida	32806	Recruiting
Research Site	Tampa	Florida	33612	Not yet recruiting
Research Site	West Palm Beach	Florida	33401	Recruiting
Research Site	Honolulu	Hawaii	96826	Not yet recruiting
Research Site	Chicago	Illinois	60607	Recruiting
Research Site	Peoria	Illinois	61637	Recruiting
Research Site	Urbana	Illinois	61801	Recruiting
Research Site	Fort Wayne	Indiana	46845	Recruiting
Research Site	Indianapolis	Indiana	46260	Recruiting
Research Site	Scarborough	Maine	04074	Recruiting
Research Site	Baltimore	Maryland	21201	Not yet recruiting
Research Site	Baltimore	Maryland	21231	Recruiting
Research Site	Silver Spring	Maryland	20910	Recruiting
Research Site	Ann Arbor	Michigan	48109	Not yet recruiting
Research Site	Ann Arbor	Michigan	48197	Recruiting
Research Site	Detroit	Michigan	48201	Withdrawn
Research Site	Minneapolis	Minnesota	55404	Recruiting
Research Site	Camden	New Jersey	08103	Not yet recruiting
Research Site	Paramus	New Jersey	07652	Recruiting
Research Site	Albuquerque	New Mexico	87109	Recruiting
Research Site	Brooklyn	New York	11220	Not yet recruiting
Research Site	Stony Brook	New York	11794	Recruiting
Research Site	The Bronx	New York	10461	Recruiting
Research Site	White Plains	New York	10601	Recruiting
Research Site	Greenville	North Carolina	27834	Recruiting
Research Site	Pinehurst	North Carolina	28374	Recruiting
Research Site	Cincinnati	Ohio	45220	Recruiting
Research Site	Cleveland	Ohio	44106	Recruiting
Research Site	Cleveland	Ohio	44109	Recruiting
Research Site	Columbus	Ohio	43219	Recruiting
Research Site	Dayton	Ohio	45459	Recruiting
Research Site	Hilliard	Ohio	43026	Recruiting
Research Site	Sylvania	Ohio	43560	Recruiting
Research Site	Eugene	Oregon	97401	Recruiting
Research Site	Portland	Oregon	97239	Not yet recruiting
Research Site	Bethlehem	Pennsylvania	18015	Recruiting
Research Site	Hershey	Pennsylvania	17033	Recruiting
Research Site	Lancaster	Pennsylvania	17601	Not yet recruiting
Research Site	Philadelphia	Pennsylvania	19107	Not yet recruiting
Research Site	Pittsburgh	Pennsylvania	15213	Not yet recruiting
Research Site	Pittsburgh	Pennsylvania	15224	Not yet recruiting
Research Site	Willow Grove	Pennsylvania	19090	Recruiting
Research Site	York	Pennsylvania	17403	Not yet recruiting
Research Site	Sioux Falls	South Dakota	57104	Not yet recruiting
Research Site	Sioux Falls	South Dakota	57105	Recruiting
Research Site	Knoxville	Tennessee	37920	Recruiting
Research Site	Nashville	Tennessee	37232	Not yet recruiting
Research Site	Austin	Texas	78758	Recruiting
Research Site	Houston	Texas	77030	Not yet recruiting
Research Site	Tyler	Texas	75702	Recruiting
Research Site	Fairfax	Virginia	22031	Recruiting
Research Site	Falls Church	Virginia	22042	Recruiting
Research Site	Norfolk	Virginia	23502	Recruiting
Research Site	Richmond	Virginia	23298	Recruiting
Research Site	Roanoke	Virginia	24016	Recruiting
Research Site	Kennewick	Washington	99336	Not yet recruiting
Research Site	Seattle	Washington	98104	Not yet recruiting
Research Site	Morgantown	West Virginia	26505	Recruiting
Research Site	Waukesha	Wisconsin	53188	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 250 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07044336, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 29, 2026 · Synced Oct 27, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07044336 live on ClinicalTrials.gov.

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