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Recruiting Phase 2 Interventional

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

ClinicalTrials.gov ID: NCT07061964

Public ClinicalTrials.gov record NCT07061964. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 8:33 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Single Arm Phase II Study of Bladder Preservation With Immunoradiotherapy After a Clinically Meaningful Response to Neoadjuvant Therapy in Patients With Muscle Invasive Bladder Cancer (BRIGHT)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial tests the effect of giving pembrolizumab in combination with radiation therapy after chemotherapy in preventing surgery to remove the bladder in patients with muscle invasive bladder cancer. Standard of care therapy includes chemotherapy before surgery (neoadjuvant) to shrink or get rid of the tumor. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Photon beam radiation therapy is a type of radiation therapy that uses x-rays or gamma rays that come from a special machine called a linear accelerator. The radiation dose is delivered at the surface of the body and goes into the tumor and through the body. Giving pembrolizumab in combination with radiation therapy after neoadjuvant chemotherapy may help prevent surgical removal of the bladder in patients with muscle invasive bladder cancer.

Study identification

NCT ID
NCT07061964
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
111 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 24, 2025
Primary completion
Jul 30, 2027
Completion
Jul 30, 2027
Last update posted
Aug 30, 2026

2025 – 2027

United States locations

U.S. sites
165
U.S. states
33
U.S. cities
133
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 Recruiting
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Recruiting
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 Recruiting
Highlands Oncology Group - Fayetteville Fayetteville Arkansas 72703 Recruiting
Highlands Oncology Group - Rogers Rogers Arkansas 72758 Recruiting
Highlands Oncology Group Springdale Arkansas 72762 Recruiting
Tower Cancer Research Foundation Beverly Hills California 90211 Recruiting
City of Hope Corona Corona California 92882 Recruiting
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
City of Hope Antelope Valley Lancaster California 93534 Recruiting
Los Angeles General Medical Center Los Angeles California 90033 Recruiting
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
City of Hope South Pasadena South Pasadena California 91030 Recruiting
Cedars-Sinai Cancer - Tarzana Tarzana California 91356 Recruiting
City of Hope Upland Upland California 91786 Recruiting
UCHealth University of Colorado Hospital Aurora Colorado 80045 Recruiting
UCHealth - Cherry Creek Denver Colorado 80206 Recruiting
Shaw Cancer Center Edwards Colorado 81632 Recruiting
Poudre Valley Hospital Fort Collins Colorado 80524 Recruiting
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 Recruiting
UCHealth Greeley Hospital Greeley Colorado 80631 Recruiting
UCHealth Highlands Ranch Hospital Highlands Ranch Colorado 80129 Recruiting
UCHealth Lone Tree Health Center Lone Tree Colorado 80124 Recruiting
Medical Center of the Rockies Loveland Colorado 80538 Recruiting
Mayo Clinic in Florida Jacksonville Florida 32224-9980 Suspended
Moffitt Cancer Center at SouthShore Ruskin Florida 33570 Recruiting
Moffitt Cancer Center-International Plaza Tampa Florida 33607 Recruiting
Moffitt Cancer Center - McKinley Campus Tampa Florida 33612 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Moffitt Cancer Center at Wesley Chapel Wesley Chapel Florida 33544 Recruiting
CTCA at Southeastern Regional Medical Center Newnan Georgia 30265 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Suspended
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Suspended
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 Suspended
Rush-Copley Medical Center Aurora Illinois 60504 Recruiting
OSF Saint Joseph Medical Center Bloomington Illinois 61701 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
Northwestern Medicine Cancer Center Old Irving Park Chicago Illinois 60641 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 Recruiting
Illinois CancerCare-Dixon Dixon Illinois 61021 Suspended
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Suspended
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 Recruiting
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026 Recruiting
Northwestern Medicine Glenview Outpatient Center Glenview Illinois 60026 Recruiting
Northwestern Medicine Grayslake Outpatient Center Grayslake Illinois 60030 Recruiting
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
HSHS Saint Elizabeth's Hospital O'Fallon Illinois 62269 Recruiting
Northwestern Medicine Oak Brook Oak Brook Illinois 60523 Recruiting
Northwestern Medicine Orland Park Orland Park Illinois 60462 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois 61615 Recruiting
OSF Saint Francis Medical Center Peoria Illinois 61637 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
McFarland Clinic - Boone Boone Iowa 50036 Suspended
Mercy Cancer Center-West Lakes Clive Iowa 50325 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 Suspended
McFarland Clinic - Jefferson Jefferson Iowa 50129 Suspended
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 Suspended
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
The Iowa Clinic PC West Des Moines Iowa 50266 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Recruiting
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 Recruiting
UofL Health Medical Center Northeast Louisville Kentucky 40245 Recruiting
University Medical Center New Orleans New Orleans Louisiana 70112 Recruiting
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
UMass Memorial Medical Center - University Campus Worcester Massachusetts 01655 Recruiting
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 Recruiting
Fairview Southdale Hospital Edina Minnesota 55435 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
University of Mississippi Medical Center Jackson Mississippi 39216 Recruiting
Saint Francis Medical Center Cape Girardeau Missouri 63703 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Community Medical Center Missoula Montana 59804 Suspended
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 Recruiting
Jefferson Cherry Hill Hospital Cherry Hill New Jersey 08002 Recruiting
Hunterdon Medical Center Flemington New Jersey 08822 Recruiting
Jersey City Medical Center Jersey City New Jersey 07302 Recruiting
Cooperman Barnabas Medical Center Livingston New Jersey 07039 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
Sidney Kimmel Cancer Center Washington Township Sewell New Jersey 08080 Recruiting
The New York Hospital Medical Center of Queens Flushing New York 11355 Recruiting
NYP/Weill Cornell Medical Center New York New York 10065 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
Sanford Broadway Medical Center Fargo North Dakota 58122 Recruiting
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 Recruiting
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 Recruiting
MetroHealth Medical Center Cleveland Ohio 44109 Recruiting
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 Recruiting
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 Recruiting
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 Recruiting
The West Clinic - Wolf River Germantown Tennessee 38138 Recruiting
Parkland Memorial Hospital Dallas Texas 75235 Recruiting
UT Southwestern Simmons Cancer Center - RedBird Dallas Texas 75237 Recruiting
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 Recruiting
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104 Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030 Recruiting
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080 Recruiting
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 Recruiting
Scott and White Memorial Hospital Temple Texas 76508 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 Recruiting
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
Fred Hutchinson Cancer Center Seattle Washington 98109 Recruiting
Swedish Medical Center-First Hill Seattle Washington 98122 Recruiting
University of Washington Medical Center - Montlake Seattle Washington 98195 Recruiting
West Virginia University Healthcare Morgantown West Virginia 26506 Recruiting
Camden Clark Medical Center Parkersburg West Virginia 26101 Recruiting
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton Appleton Wisconsin 54915 Recruiting
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield Brookfield Wisconsin 53045 Recruiting
Ascension Calumet Hospital-Chilton Chilton Wisconsin 53014 Recruiting
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson Franklin Wisconsin 53132 Recruiting
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303 Recruiting
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon Mequon Wisconsin 53097 Recruiting
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus Milwaukee Wisconsin 53211 Recruiting
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154 Recruiting
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh Oshkosh Wisconsin 54904 Recruiting
Ascension All Saints Hospital-Spring Street-Racine Racine Wisconsin 53405 Recruiting
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan Wisconsin 53081 Recruiting
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin 54235-1495 Recruiting
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa Wauwatosa Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07061964, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 30, 2026 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07061964 live on ClinicalTrials.gov.

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