Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

ClinicalTrials.gov ID: NCT07061964

Public ClinicalTrials.gov record NCT07061964. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Single Arm Phase II Study of Bladder Preservation With Immunoradiotherapy After a Clinically Meaningful Response to Neoadjuvant Therapy in Patients With Muscle Invasive Bladder Cancer (BRIGHT)

Study identification

NCT ID: NCT07061964
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 111 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Computed Tomography Procedure
Cystoscopy Procedure
Magnetic Resonance Imaging Procedure
Pembrolizumab Biological
Photon Beam Radiation Therapy Radiation
Positron Emission Tomography Procedure
Questionnaire Administration Other
Transurethral Resection of Bladder Tumor Procedure

Procedure · Biological · Radiation + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 24, 2025
Primary completion: Jul 30, 2027
Completion: Jul 30, 2027
Last update posted: May 6, 2026

2025 – 2027

United States locations

U.S. sites: 134
U.S. states: 30
U.S. cities: 108

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Recruiting
Banner MD Anderson Cancer Center	Gilbert	Arizona	85234	Recruiting
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Recruiting
Tower Cancer Research Foundation	Beverly Hills	California	90211	Recruiting
City of Hope Corona	Corona	California	92882	Recruiting
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Recruiting
City of Hope at Irvine Lennar	Irvine	California	92618	Recruiting
City of Hope Antelope Valley	Lancaster	California	93534	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
City of Hope South Pasadena	South Pasadena	California	91030	Recruiting
Cedars-Sinai Cancer - Tarzana	Tarzana	California	91356	Recruiting
City of Hope Upland	Upland	California	91786	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Recruiting
UCHealth - Cherry Creek	Denver	Colorado	80206	Recruiting
Shaw Cancer Center	Edwards	Colorado	81632	Recruiting
Poudre Valley Hospital	Fort Collins	Colorado	80524	Recruiting
Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	80528	Recruiting
UCHealth Greeley Hospital	Greeley	Colorado	80631	Recruiting
Medical Center of the Rockies	Loveland	Colorado	80538	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224-9980	Recruiting
Moffitt Cancer Center at SouthShore	Ruskin	Florida	33570	Recruiting
Moffitt Cancer Center-International Plaza	Tampa	Florida	33607	Recruiting
Moffitt Cancer Center - McKinley Campus	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center at Wesley Chapel	Wesley Chapel	Florida	33544	Recruiting
CTCA at Southeastern Regional Medical Center	Newnan	Georgia	30265	Recruiting
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Suspended
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Suspended
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Suspended
Rush-Copley Medical Center	Aurora	Illinois	60504	Recruiting
OSF Saint Joseph Medical Center	Bloomington	Illinois	61701	Recruiting
Illinois CancerCare-Bloomington	Bloomington	Illinois	61704	Recruiting
Illinois CancerCare-Canton	Canton	Illinois	61520	Recruiting
Illinois CancerCare-Carthage	Carthage	Illinois	62321	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Illinois CancerCare-Dixon	Dixon	Illinois	61021	Suspended
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Suspended
Illinois CancerCare-Eureka	Eureka	Illinois	61530	Recruiting
NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	60201	Recruiting
Illinois CancerCare-Galesburg	Galesburg	Illinois	61401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Glenview Outpatient Center	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Grayslake Outpatient Center	Grayslake	Illinois	60030	Recruiting
NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	60035	Recruiting
Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	61443	Recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Recruiting
Illinois CancerCare-Macomb	Macomb	Illinois	61455	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
HSHS Saint Elizabeth's Hospital	O'Fallon	Illinois	62269	Recruiting
Northwestern Medicine Oak Brook	Oak Brook	Illinois	60523	Recruiting
Northwestern Medicine Orland Park	Orland Park	Illinois	60462	Recruiting
Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	61350	Recruiting
Illinois CancerCare-Pekin	Pekin	Illinois	61554	Recruiting
Illinois CancerCare-Peoria	Peoria	Illinois	61615	Recruiting
OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	61615	Recruiting
OSF Saint Francis Medical Center	Peoria	Illinois	61637	Recruiting
Illinois CancerCare-Peru	Peru	Illinois	61354	Recruiting
Illinois CancerCare-Princeton	Princeton	Illinois	61356	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Illinois CancerCare - Washington	Washington	Illinois	61571	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
McFarland Clinic - Boone	Boone	Iowa	50036	Suspended
Mercy Cancer Center-West Lakes	Clive	Iowa	50325	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
McFarland Clinic - Trinity Cancer Center	Fort Dodge	Iowa	50501	Suspended
McFarland Clinic - Jefferson	Jefferson	Iowa	50129	Suspended
McFarland Clinic - Marshalltown	Marshalltown	Iowa	50158	Suspended
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
The Iowa Clinic PC	West Des Moines	Iowa	50266	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
University Medical Center New Orleans	New Orleans	Louisiana	70112	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Community Medical Center	Missoula	Montana	59804	Suspended
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Hunterdon Medical Center	Flemington	New Jersey	08822	Recruiting
Saint Barnabas Medical Center	Livingston	New Jersey	07039	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
The New York Hospital Medical Center of Queens	Flushing	New York	11355	Recruiting
NYP/Weill Cornell Medical Center	New York	New York	10065	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	19090	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
The West Clinic - Wolf River	Germantown	Tennessee	38138	Recruiting
Parkland Memorial Hospital	Dallas	Texas	75235	Recruiting
UT Southwestern Simmons Cancer Center - RedBird	Dallas	Texas	75237	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	76104	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	75080	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
Dartmouth Cancer Center - North	Saint Johnsbury	Vermont	05819	Recruiting
VCU Massey Cancer Center at Stony Point	Richmond	Virginia	23235	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Swedish Medical Center-First Hill	Seattle	Washington	98122	Recruiting
West Virginia University Healthcare	Morgantown	West Virginia	26506	Recruiting
Camden Clark Medical Center	Parkersburg	West Virginia	26101	Recruiting
Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	54301	Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	54303	Recruiting
Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	54154	Recruiting
Saint Vincent Hospital Cancer Center at Sheboygan	Sheboygan	Wisconsin	53081	Recruiting
Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	54235-1495	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07061964, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07061964 live on ClinicalTrials.gov.

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