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Recruiting Phase 3 Interventional

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

ClinicalTrials.gov ID: NCT07061977

Public ClinicalTrials.gov record NCT07061977. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:10 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

NRG-GY037: A Phase III Study of Induction Pembrolizumab and Chemotherapy Followed by Chemoradiation and Pembrolizumab Versus Chemoradiation and Pembrolizumab Both Followed by Pembrolizumab for High Risk Locally Advanced Cervical Cancer

Study identification

NCT ID
NCT07061977
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
336 participants

Conditions and interventions

Interventions

  • Biospecimen Collection Procedure
  • Brachytherapy Radiation
  • Carboplatin Drug
  • Chest Radiography Procedure
  • Cisplatin Drug
  • Computed Tomography Procedure
  • External Beam Radiation Therapy Radiation
  • Intensity-Modulated Radiation Therapy Radiation
  • Magnetic Resonance Imaging Procedure
  • Paclitaxel Drug
  • Pembrolizumab Biological
  • Positron Emission Tomography Procedure

Procedure · Radiation · Drug + 1 more

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 4, 2025
Primary completion
Dec 30, 2030
Completion
Dec 30, 2030
Last update posted
May 6, 2026

2025 – 2030

United States locations

U.S. sites
232
U.S. states
37
U.S. cities
185
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 Not yet recruiting
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Recruiting
Kaiser Permanente-Bellflower Bellflower California 90706 Recruiting
City of Hope Corona Corona California 92882 Recruiting
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
Kaiser Permanente South Bay Harbor City California 90710 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
Kaiser Permanente-Irvine Irvine California 92618 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92093 Recruiting
City of Hope Antelope Valley Lancaster California 93534 Suspended
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 Recruiting
Kaiser Permanente West Los Angeles Los Angeles California 90034 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
Kaiser Permanente - Panorama City Panorama City California 91402 Recruiting
Kaiser Permanente-San Diego Zion San Diego California 92120 Recruiting
Kaiser Permanente-San Marcos San Marcos California 92078 Recruiting
City of Hope South Pasadena South Pasadena California 91030 Recruiting
City of Hope Upland Upland California 91786 Recruiting
Kaiser Permanente-Woodland Hills Woodland Hills California 91367 Recruiting
UCHealth University of Colorado Hospital Aurora Colorado 80045 Recruiting
UCHealth Highlands Ranch Hospital Highlands Ranch Colorado 80129 Recruiting
Danbury Hospital Danbury Connecticut 06810 Recruiting
Norwalk Hospital Norwalk Connecticut 06856 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs Coral Springs Florida 33065 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
Broward Health Medical Center Fort Lauderdale Florida 33316 Recruiting
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood Florida 33021 Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood Florida 33021 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia North Miami Florida 33181 Recruiting
Orlando Health Cancer Institute Orlando Florida 32806 Recruiting
Memorial Hospital West Pembroke Pines Florida 33028 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Piedmont Hospital Atlanta Georgia 30309 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Decatur Hospital Decatur Georgia 30033 Recruiting
CTCA at Southeastern Regional Medical Center Newnan Georgia 30265 Recruiting
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 Recruiting
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 Recruiting
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Suspended
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 Recruiting
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 Recruiting
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 Recruiting
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 Recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Suspended
Northwestern University Chicago Illinois 60611 Recruiting
Rush MD Anderson Cancer Center Chicago Illinois 60612 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Suspended
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Loyola University Medical Center Maywood Illinois 60153 Recruiting
Northwestern Medicine Oak Brook Oak Brook Illinois 60523 Recruiting
Northwestern Medicine Orland Park Orland Park Illinois 60462 Recruiting
UW Health Carbone Cancer Center Rockford Rockford Illinois 61114 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Midwestern Regional Medical Center Zion Illinois 60099 Recruiting
Parkview Regional Medical Center Fort Wayne Indiana 46845 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
Mercy Hospital Cedar Rapids Iowa 52403 Recruiting
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Recruiting
University of Kansas Hospital-Indian Creek Campus Overland Park Kansas 66211 Recruiting
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Recruiting
West Jefferson Medical Center Marrero Louisiana 70072 Recruiting
East Jefferson General Hospital Metairie Louisiana 70006 Recruiting
LSU Healthcare Network / Metairie Multi-Specialty Clinic Metairie Louisiana 70006 Recruiting
University Medical Center New Orleans New Orleans Louisiana 70112 Recruiting
Ochsner Baptist Medical Center New Orleans Louisiana 70115 Recruiting
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 Recruiting
MaineHealth Coastal Cancer Treatment Center Bath Maine 04530 Recruiting
MaineHealth Maine Medical Center - Portland Portland Maine 04102 Recruiting
MaineHealth Cancer Care Center of York County Sanford Maine 04073 Recruiting
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 Recruiting
Bronson Methodist Hospital Kalamazoo Michigan 49007 Recruiting
West Michigan Cancer Center Kalamazoo Michigan 49007 Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 Suspended
Freeman Health System Joplin Missouri 64804 Recruiting
University of Kansas Cancer Center - Briarcliff Kansas City Missouri 64116 Recruiting
University of Kansas Cancer Center - North Kansas City Missouri 64154 Recruiting
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 Recruiting
Phelps Health Delbert Day Cancer Institute Rolla Missouri 65401 Recruiting
Mercy Hospital Springfield Springfield Missouri 65804 Recruiting
Mercy Hospital Saint Louis St Louis Missouri 63141 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Community Medical Center Missoula Montana 59804 Suspended
Nebraska Methodist Hospital Omaha Nebraska 68114 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Cooper Hospital University Medical Center Camden New Jersey 08103 Recruiting
Jersey City Medical Center Jersey City New Jersey 07302 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
Rutgers New Jersey Medical School Newark New Jersey 07101 Recruiting
Capital Health Medical Center-Hopewell Pennington New Jersey 08534 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
Northwell Health Imbert Cancer Center Bay Shore New York 11706 Recruiting
Roswell Park Cancer Institute Buffalo New York 14263 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Northwell Health Physician Partners at Flushing Flushing New York 11354 Recruiting
Northwell Health Physicians Partners Radiation Medicine at Queens Forest Hills New York 11375 Recruiting
Northwell Health Cancer Institute at Huntington Greenlawn New York 11740 Recruiting
Memorial Sloan Kettering Westchester Harrison New York 10604 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Mount Sinai Chelsea New York New York 10011 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Manhattan Eye Ear and Throat Hospital New York New York 10065 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Lenox Hill Hospital New York New York 10075 Recruiting
Upstate Cancer Center Radiation Oncology at Oswego Oswego New York 13126 Recruiting
Queens Cancer Center Rego Park New York 11374 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
State University of New York Upstate Medical University Syracuse New York 13210 Recruiting
Upstate Cancer Center at Hill Radiation Oncology Syracuse New York 13210 Recruiting
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 Recruiting
Montefiore Medical Center-Weiler Hospital The Bronx New York 10461 Suspended
Montefiore Medical Center - Moses Campus The Bronx New York 10467 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Upstate Cancer Center at Verona Verona New York 13478 Recruiting
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 Recruiting
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 Recruiting
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Levine Cancer Institute-Gaston Gastonia North Carolina 28054 Recruiting
Duke Women's Cancer Care Raleigh Raleigh North Carolina 27607 Recruiting
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122 Recruiting
Aultman Health Foundation Canton Ohio 44710 Recruiting
Miami Valley Hospital South Centerville Ohio 45459 Recruiting
Geauga Hospital Chardon Ohio 44024 Recruiting
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
Cleveland Clinic Foundation Cleveland Ohio 44195 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
Miami Valley Hospital Dayton Ohio 45409 Recruiting
Miami Valley Hospital North Dayton Ohio 45415 Recruiting
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 Recruiting
Miami Valley Cancer Care and Infusion Greenville Ohio 45331 Recruiting
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124 Recruiting
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 Recruiting
University Hospitals Parma Medical Center Parma Ohio 44129 Recruiting
ProMedica Flower Hospital Sylvania Ohio 43560 Recruiting
Upper Valley Medical Center Troy Ohio 45373 Recruiting
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 Recruiting
UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio 44145 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146 Recruiting
Clackamas Radiation Oncology Center Clackamas Oregon 97015 Recruiting
Providence Newberg Medical Center Newberg Oregon 97132 Recruiting
Providence Willamette Falls Medical Center Oregon City Oregon 97045 Recruiting
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Kaiser Permanente Northwest Portland Oregon 97227 Recruiting
Oregon Health and Science University Portland Oregon 97239 Recruiting
Legacy Meridian Park Hospital Tualatin Oregon 97062 Recruiting
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103 Recruiting
Saint Luke's Cancer Center - Allentown Allentown Pennsylvania 18104 Recruiting
Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania 18015 Recruiting
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017 Recruiting
Geisinger Medical Center Danville Pennsylvania 17822 Recruiting
Pocono Medical Center East Stroudsburg Pennsylvania 18301 Recruiting
Saint Luke's Hospital-Anderson Campus Easton Pennsylvania 18045 Recruiting
UPMC Hillman Cancer Center Erie Erie Pennsylvania 16505 Recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania 17109 Recruiting
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 Recruiting
IRMC Cancer Center Indiana Pennsylvania 15701 Recruiting
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 Recruiting
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
UPMC-Magee Womens Hospital Pittsburgh Pennsylvania 15213 Recruiting
UPMC-Passavant Hospital Pittsburgh Pennsylvania 15237 Recruiting
Saint Luke's Hospital - Upper Bucks Campus Quakertown Pennsylvania 18951 Recruiting
UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania 16346 Recruiting
Saint Luke's Hospital - Monroe Campus Stroudsburg Pennsylvania 18360 Recruiting
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 Recruiting
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 Recruiting
Women and Infants Hospital Providence Rhode Island 02905 Recruiting
Gibbs Cancer Center-Gaffney Gaffney South Carolina 29341 Recruiting
Gibbs Cancer Center-Pelham Greer South Carolina 29651 Recruiting
Spartanburg Medical Center Spartanburg South Carolina 29303 Recruiting
Avera Cancer Institute Sioux Falls South Dakota 57105 Recruiting
Parkland Memorial Hospital Dallas Texas 75235 Recruiting
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 Recruiting
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104 Recruiting
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080 Recruiting
Farmington Health Center Farmington Utah 84025 Recruiting
University of Utah Sugarhouse Health Center Salt Lake City Utah 84106 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Inova Alexandria Hospital Alexandria Virginia 22304 Recruiting
University of Virginia Cancer Center Charlottesville Virginia 22908 Recruiting
Inova Schar Cancer Institute Fairfax Virginia 22031 Recruiting
Inova Fair Oaks Hospital Fairfax Virginia 22033 Recruiting
Inova Fairfax Hospital Falls Church Virginia 22042 Recruiting
Inova Loudoun Hospital Leesburg Virginia 20176 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
Legacy Salmon Creek Hospital Vancouver Washington 98686 Recruiting
West Virginia University Healthcare Morgantown West Virginia 26506 Recruiting
Camden Clark Medical Center Parkersburg West Virginia 26101 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07061977, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 6, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07061977 live on ClinicalTrials.gov.

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