ClinicalTrials.gov record
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
ClinicalTrials.gov ID: NCT07064473
Public ClinicalTrials.gov record NCT07064473. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 5:04 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EASi-PROTKT™ - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Type 2 Diabetes, Hypertension and Established Cardiovascular Disease
Study identification
- NCT ID
- NCT07064473
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Boehringer Ingelheim
- Industry
- Enrollment
- 11,800 participants
Conditions and interventions
Interventions
- Empagliflozin Drug
- Placebo matching Vicadrostat Drug
- Vicadrostat Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 8, 2025
- Primary completion
- Dec 13, 2029
- Completion
- Dec 20, 2029
- Last update posted
- Apr 28, 2026
2025 – 2029
United States locations
- U.S. sites
- 216
- U.S. states
- 39
- U.S. cities
- 180
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group, LLC | Anniston | Alabama | 36207 | Recruiting |
| Eastern Shore Research Group | Fairhope | Alabama | 36532 | Recruiting |
| Lakeview Clinical Research | Guntersville | Alabama | 35976 | Recruiting |
| Arizona Clinical Trials - Chandler | Chandler | Arizona | 85225 | Recruiting |
| Elite Clinical Studies | Phoenix | Arizona | 85018 | Recruiting |
| Clinical Research Institute of Arizona, LLC | Sun City West | Arizona | 85375 | Recruiting |
| Fiel Family & Sports Medicine | Tempe | Arizona | 85283 | Recruiting |
| Arizona Clinical Trials | Tucson | Arizona | 85711 | Recruiting |
| Yuma Clinical Trials | Yuma | Arizona | 85364 | Recruiting |
| National Heart Institute - Beverly Hills | Beverly Hills | California | 90211 | Recruiting |
| Hope Clinical Research | Canoga Park | California | 91303 | Recruiting |
| John Muir Physician Network Clinical Research Center | Concord | California | 94520 | Recruiting |
| Velocity Clinical Research-Huntington Park | Huntington Park | California | 90255 | Recruiting |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | Recruiting |
| First Valley Medical Group | Lancaster | California | 93534 | Recruiting |
| ARK Clinical Research | Long Beach | California | 90815 | Recruiting |
| Diabetes Associates Medical Group | Orange | California | 92868 | Recruiting |
| Empire Clinical Research | Pomona | California | 91767 | Not yet recruiting |
| Velocity Clinical Research - San Bernardino | San Bernardino | California | 92408 | Recruiting |
| Acclaim Clinical Research | San Diego | California | 92120 | Recruiting |
| NorthBay Clinical Research, LLC | Santa Rosa | California | 95405 | Not yet recruiting |
| The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | Not yet recruiting |
| Blue Coast Research Center, LLC | Vista | California | 92081 | Recruiting |
| Rocky Mountain Regional VA Medical Center | Aurora | Colorado | 80045 | Not yet recruiting |
| OptumCare Clinical Trials, LLC | Golden | Colorado | 80401 | Recruiting |
| Cardiology Physicians of Fairfield County - Bridgeport | Bridgeport | Connecticut | 06606 | Recruiting |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | Not yet recruiting |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | Recruiting |
| Cardiology Associates of Fairfield County | Stamford | Connecticut | 06905 | Recruiting |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | Recruiting |
| Clinical Research of West Florida, Inc. | Clearwater | Florida | 33765 | Recruiting |
| Beautiful Minds Clinical Research Center | Cutler Bay | Florida | 33157 | Recruiting |
| Hillcrest Medical Research | DeLand | Florida | 32720 | Recruiting |
| University Clinical Research Deland, LLC | DeLand | Florida | 32720 | Recruiting |
| Universal Axon Clinical Research | Doral | Florida | 33166 | Recruiting |
| Northeast Research Institute | Fleming Island | Florida | 32003 | Recruiting |
| Covenant Metabolic Specialists, LLC - Fort Myers | Fort Myers | Florida | 33912 | Recruiting |
| Velocity Clinical Research-Hallandale Beach-67888 | Hallandale | Florida | 33009 | Recruiting |
| Indago Research and Health Center | Hialeah | Florida | 33012 | Recruiting |
| Northeast Research Institute | Jacksonville | Florida | 32204 | Recruiting |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | Recruiting |
| East Coast Institute for Research, LLC - Southside | Jacksonville | Florida | 32216 | Recruiting |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | Recruiting |
| Walgreens - Kissimmee - Site 4442 | Kissimmee | Florida | 34736 | Recruiting |
| East Coast Institute for Research - Lake City | Lake City | Florida | 32055 | Recruiting |
| Clinical Research of Central Florida - Lakeland | Lakeland | Florida | 33805 | Not yet recruiting |
| Finlay Medical Research Corp | Miami | Florida | 33126 | Recruiting |
| Optimus U Corporation-Miami-69452 | Miami | Florida | 33135 | Recruiting |
| Oceane7 Clinical Research | Miami | Florida | 33144 | Recruiting |
| Research Institute of South Florida, Inc. | Miami | Florida | 33173 | Recruiting |
| IMIC Inc. | Miami | Florida | 33176 | Recruiting |
| Alma Clinical Research, Inc. | Miami | Florida | 33184 | Recruiting |
| Advanced Research for Health Improvement, LLC | Naples | Florida | 34102 | Recruiting |
| Suncoast Clinical Research | New Port Richey | Florida | 34652 | Recruiting |
| Florida Institute for Clinical Research | Orlando | Florida | 32825 | Not yet recruiting |
| Ormond Beach Clinical Research | Ormond Beach | Florida | 32174 | Recruiting |
| Cardiology Partners Clinical Research Institute | Palm Beach Gardens | Florida | 33410 | Not yet recruiting |
| Innovation Medical Research Center | Palmetto Bay | Florida | 33157 | Not yet recruiting |
| Center for Diabetes, Obesity and Metabolism | Pembroke Pines | Florida | 33024 | Recruiting |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | Recruiting |
| Covenant Metabolic Specialists, LLC - Brandon | Riverview | Florida | 33578 | Not yet recruiting |
| East Coast Institute for Research, LLC-Saint Augustine-63032 | Saint Augustine | Florida | 32086 | Recruiting |
| IMA Clinical Research St. Petersburg | St. Petersburg | Florida | 33704 | Recruiting |
| Covenant Metabolic Specialists, LLC - Sarasota | University Park | Florida | 34201 | Recruiting |
| Cardiology Partners Clinical Research Institute | Wellington | Florida | 33449 | Not yet recruiting |
| Centricity Research, Endocrine Consultants | Columbus | Georgia | 31904 | Recruiting |
| NSC Research Inc | Johns Creek | Georgia | 30024 | Recruiting |
| Physicians Research Associates, LLC | Lawrenceville | Georgia | 30046 | Not yet recruiting |
| The Jones Center for Diabetes and Endocrine Wellness | Macon | Georgia | 31210 | Recruiting |
| Urban Family Practice Associates, PC | Marietta | Georgia | 30067 | Recruiting |
| Javara-Savannah-67450 | Savannah | Georgia | 31406 | Recruiting |
| Javara Research - Thomasville | Thomasville | Georgia | 31792 | Recruiting |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | Recruiting |
| Pacific Diabetes & Endocrine Center | Honolulu | Hawaii | 96817 | Recruiting |
| Rocky Mountain Clinical Research - Idaho Falls | Idaho Falls | Idaho | 83404 | Recruiting |
| Cedar Crosse Research Center | Chicago | Illinois | 60607 | Not yet recruiting |
| Walgreens - Chicago - Site 162 | Chicago | Illinois | 60615 | Recruiting |
| Accellacare of Duly - Lombard | Lombard | Illinois | 60148 | Not yet recruiting |
| Accellacare of Duly | Oak Lawn | Illinois | 60453 | Not yet recruiting |
| American Health Network - Avon | Avon | Indiana | 46123 | Recruiting |
| Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana | 46514 | Not yet recruiting |
| American Health Network - Franklin | Franklin | Indiana | 46131 | Recruiting |
| American Health Network - Greenfield | Greenfield | Indiana | 46140 | Recruiting |
| American Health Network - Muncie | Muncie | Indiana | 47304 | Recruiting |
| Reid Physician Associates | Richmond | Indiana | 47374 | Recruiting |
| AMR El Dorado | El Dorado | Kansas | 67042 | Recruiting |
| Cotton O'Neil Diabetes & Endocrinology Center | Topeka | Kansas | 66606 | Recruiting |
| Tekton Research - Wichita | Wichita | Kansas | 67218 | Recruiting |
| Qualmedica Research - Bowling Green | Bowling Green | Kentucky | 42101 | Recruiting |
| The Research Group of Lexington | Lexington | Kentucky | 40503 | Recruiting |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | Recruiting |
| Grace Research, LLC-Bossier City-51040 | Bossier City | Louisiana | 71111 | Not yet recruiting |
| Louisiana Heart Center - Covington | Covington | Louisiana | 70433 | Recruiting |
| IMA Clinical Research Monroe | Monroe | Louisiana | 71201 | Recruiting |
| Grace Research, LLC-Shreveport-64616 | Shreveport | Louisiana | 71105 | Not yet recruiting |
| Louisiana Heart Center - Slidell | Slidell | Louisiana | 70458 | Recruiting |
| Monroe Research, LLC | West Monroe | Louisiana | 71291 | Recruiting |
| Southern Clinical Research - Zachary | Zachary | Louisiana | 70791 | Not yet recruiting |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | Recruiting |
| Medstar Montgomery Medical Center | Olney | Maryland | 20832 | Not yet recruiting |
| MD Medical Research | Oxon Hill | Maryland | 20745 | Recruiting |
| TidalHealth, Inc. | Salisbury | Maryland | 21804 | Recruiting |
| Walgreens - Malden - Site 4966 | Malden | Massachusetts | 02148 | Recruiting |
| ActivMed Practices & Research | Methuen | Massachusetts | 01844 | Recruiting |
| Revival Research Institute, LLC - Dearborn | Dearborn | Michigan | 48126 | Recruiting |
| Aa Mrc Llc | Flint | Michigan | 48504 | Recruiting |
| Elite Research Center, LLC | Flint | Michigan | 48532 | Recruiting |
| Advanced Cardiology Associates | Rochester Hills | Michigan | 48307 | Not yet recruiting |
| Oakland Medical Center | Troy | Michigan | 48085 | Recruiting |
| Prime Health and Wellness | Fayette | Mississippi | 39069 | Not yet recruiting |
| Memorial Hospital Gulfport | Gulfport | Mississippi | 39501 | Not yet recruiting |
| Jefferson City Medical Group | Jefferson City | Missouri | 65109 | Recruiting |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | Recruiting |
| St. Louis Heart and Vascular, P.C. | St Louis | Missouri | 63136 | Not yet recruiting |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | Not yet recruiting |
| Billings Clinic - Billings | Billings | Montana | 59101 | Not yet recruiting |
| Methodist Physicians Clinic | Fremont | Nebraska | 68025 | Recruiting |
| Omaha VA Medical Center | Omaha | Nebraska | 68105 | Not yet recruiting |
| Quality Clinical Research - Omaha | Omaha | Nebraska | 68114 | Recruiting |
| Las Vegas Clinical Trials | Las Vegas | Nevada | 89030 | Recruiting |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | Recruiting |
| Palm Research Center | Las Vegas | Nevada | 89128 | Recruiting |
| Vector Clinical Trials | Las Vegas | Nevada | 89128 | Recruiting |
| Palm Research Center | Las Vegas | Nevada | 89148 | Recruiting |
| Walgreens - North Las Vegas - Site 5814 | North Las Vegas | Nevada | 89032 | Recruiting |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | Recruiting |
| NJ Heart LLC | Linden | New Jersey | 07036 | Recruiting |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | Not yet recruiting |
| New Mexico Clinical Research and Osteoporosis Center, Inc. | Albuquerque | New Mexico | 87106 | Recruiting |
| IMA Clinical Research Albuquerque | Albuquerque | New Mexico | 87109 | Not yet recruiting |
| Albany Med Health System - Washington Avenue Extension | Albany | New York | 12203 | Not yet recruiting |
| Velocity Clinical Research - Binghamton | Binghamton | New York | 13905 | Recruiting |
| RCR - Buffalo | Buffalo | New York | 14217 | Recruiting |
| NYC Research Inc. | New York | New York | 10016 | Recruiting |
| New York Cardiovascular Specialist PC | New York | New York | 10035 | Not yet recruiting |
| Northwell Health - Peconic Bay Medical Group at Riverhead | Riverhead | New York | 11091 | Not yet recruiting |
| Rochester Clinical Research, Inc | Rochester | New York | 14609 | Recruiting |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | Not yet recruiting |
| Southgate Medical Group/ Southgate Medical Park | West Seneca | New York | 14224 | Not yet recruiting |
| Great Lakes Medical Research | Westfield | New York | 14787 | Recruiting |
| Cary Cardiology | Cary | North Carolina | 27518 | Not yet recruiting |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| Physicians East, PA | Greenville | North Carolina | 27834 | Recruiting |
| IMA Clinical Research Lenoir | Lenoir | North Carolina | 28645 | Recruiting |
| Accellacare-Mooresville-69123 | Mooresville | North Carolina | 28117 | Recruiting |
| Lucas Research, Inc. | Morehead City | North Carolina | 28557 | Recruiting |
| Accellacare-Wilmington-67123 | Wilmington | North Carolina | 28401 | Not yet recruiting |
| Wake Forest University Health Sciences-Winston-Salem-61707 | Winston-Salem | North Carolina | 27157 | Recruiting |
| Lillestol Research, LLC | Fargo | North Dakota | 58104 | Recruiting |
| The Christ Hospital | Cincinnati | Ohio | 45219 | Not yet recruiting |
| Velocity Clinical Research-Cincinnati-69044 | Cincinnati | Ohio | 45242 | Recruiting |
| Centricity Research-Columbus-68879 | Columbus | Ohio | 43213 | Recruiting |
| Remington-Davis Clinical Research, Inc | Columbus | Ohio | 43215 | Recruiting |
| Clinical Research Institute of Ohio, LLC | Westlake | Ohio | 44145 | Not yet recruiting |
| Tekton Research-Edmond-68875 | Edmond | Oklahoma | 73013 | Recruiting |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | Recruiting |
| Tekton Research-Yukon-68998 | Yukon | Oklahoma | 73099 | Recruiting |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | Recruiting |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Tristar Clinical Investigations PC | Philadelphia | Pennsylvania | 19114 | Recruiting |
| Preferred Primary Care Physicians-Pittsburgh-63932 | Pittsburgh | Pennsylvania | 15236 | Recruiting |
| Preferred Primary Care Physicians, Inc | Pittsburgh | Pennsylvania | 15243 | Recruiting |
| Frontier Clinical Research LLC - Scottdale | Scottdale | Pennsylvania | 15683 | Recruiting |
| Frontier Clinical Research | Smithfield | Pennsylvania | 15478 | Recruiting |
| Preferred Primary Care Physicians-Uniontown-69137 | Uniontown | Pennsylvania | 15401 | Recruiting |
| Suburban Research Associates | West Chester | Pennsylvania | 19380 | Recruiting |
| Cardiology Consultants of Philadelphia | Yardley | Pennsylvania | 19067 | Recruiting |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | Recruiting |
| Velocity Clinical Research-Gaffney-69046 | Gaffney | South Carolina | 29340 | Recruiting |
| Tribe Clinical Research LLC | Greenville | South Carolina | 29607 | Recruiting |
| Velocity Clinical Research-Union-68888 | Union | South Carolina | 29379 | Recruiting |
| Dunes Clinical Research | Dakota Dunes | South Dakota | 57049 | Recruiting |
| Alliance for Multispecialty Research, LLC-Knoxville-69693 | Knoxville | Tennessee | 37909 | Recruiting |
| Pinnacle Clinical Research - Austin | Austin | Texas | 78757 | Recruiting |
| South Texas Research Institute - Brownsville | Brownsville | Texas | 78520 | Not yet recruiting |
| Headlands Research | Brownsville | Texas | 78526 | Not yet recruiting |
| Soltero Cardiovascular Research Center | Dallas | Texas | 75226 | Recruiting |
| Javara Inc / Texas Health Care, PLLC | Dallas | Texas | 75230 | Recruiting |
| North Texas Endocrine Center | Dallas | Texas | 75231 | Recruiting |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | Not yet recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| South Texas Research Institute-Edinburg-67012 | Edinburg | Texas | 78539 | Not yet recruiting |
| Academy Of Diabetes, Thyroid And Endocrine, PA | El Paso | Texas | 79935 | Not yet recruiting |
| Care United Research | Forney | Texas | 75126 | Recruiting |
| Texas Health Physicians Group | Fort Worth | Texas | 76107 | Recruiting |
| Diabetes and Thyroid Center of Fort Worth | Fort Worth | Texas | 76132 | Recruiting |
| Victorium Clinical Research | Houston | Texas | 77024 | Recruiting |
| Houston Research Institute | Houston | Texas | 77079 | Not yet recruiting |
| Epic Clinical Research | Lewisville | Texas | 75057 | Recruiting |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | Not yet recruiting |
| Texas Diabetes Institute | San Antonio | Texas | 78207 | Not yet recruiting |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | Recruiting |
| Pinnacle Clinical Research, LLC | San Antonio | Texas | 78229 | Not yet recruiting |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | Recruiting |
| Tekton Research-San Antonio-68916 | San Antonio | Texas | 78258 | Recruiting |
| Javara Inc. and Privia Medical Group Gulf Coast, PLLC | San Marcos | Texas | 78666 | Recruiting |
| Consano Clinical Research | Shavano Park | Texas | 78231 | Recruiting |
| Sherman Clinical Research | Sherman | Texas | 75090 | Recruiting |
| Javara Inc.-Stephenville-68996 | Stephenville | Texas | 76401 | Recruiting |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | Recruiting |
| Velocity Clinical Research, Waco | Waco | Texas | 76710 | Recruiting |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | Not yet recruiting |
| Olympus Family Medicine | Salt Lake City | Utah | 84117 | Recruiting |
| Velocity Clinical Research-West Jordan-69043 | West Jordan | Utah | 84088 | Recruiting |
| Seven Corners Medical Center | Falls Church | Virginia | 22044 | Recruiting |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | Recruiting |
| York Clinical Research | Norfolk | Virginia | 23504 | Recruiting |
| Dominion Medical Associates - Downtown | Richmond | Virginia | 23219 | Recruiting |
| Richmond VA Medical Center | Richmond | Virginia | 23249 | Not yet recruiting |
| Selma Medical Associates, Winchester | Winchester | Virginia | 22601 | Recruiting |
| Universal Research Group, LLC | Tacoma | Washington | 98405 | Recruiting |
| Frontier Clinical Research, LLC - Morgantown | Morgantown | West Virginia | 26505 | Not yet recruiting |
| Clinical Investigation Specialists, Inc.-Kenosha-69111 | Kenosha | Wisconsin | 53144 | Recruiting |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | Not yet recruiting |
| Allegiance Research Specialists | Wauwatosa | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 934 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07064473, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07064473 live on ClinicalTrials.gov.