A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

ClinicalTrials.gov ID: NCT07065240

Public ClinicalTrials.gov record NCT07065240. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 10:53 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled, Monotherapy Study of the Efficacy, Safety, and Tolerability of SPT-300 in Adults With Major Depressive Disorder (MDD), With or Without Anxious Distress

Study identification

NCT ID: NCT07065240
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Seaport Therapeutics; Industry
Enrollment: 360 participants

Conditions and interventions

Conditions

Interventions

Placebo Drug
SPT-300 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 18, 2025
Primary completion: Feb 28, 2027
Completion: Feb 28, 2027
Last update posted: May 18, 2026

2025 – 2027

United States locations

U.S. sites: 28
U.S. states: 11
U.S. cities: 27

Facility	City	State	ZIP	Site status
Seaport Investigator Site	Chino	California	91710	Recruiting
Seaport Investigator Site	Garden Grove	California	92845-2506	Recruiting
Seaport Investigator Site	Glendale	California	91206	Recruiting
Seaport Investigator Site	San Jose	California	95124	Recruiting
Seaport Investigator Site	Cromwell	Connecticut	06416	Recruiting
Seaport Investigator Site	Jacksonville	Florida	32256	Recruiting
Seaport Investigator Site	Lauderhill	Florida	33319	Recruiting
Seaport Investigator Site	Orlando	Florida	32801	Recruiting
Seaport Investigator Site	Palm Bay	Florida	32905	Recruiting
Seaport Investigator Site	West Palm Beach	Florida	33407	Recruiting
Seaport Investigator Site	Atlanta	Georgia	30328	Recruiting
Seaport Investigator Site	Decatur	Georgia	30030	Recruiting
Seaport Investigator Site	Marietta	Georgia	30060	Recruiting
Seaport Investigator Site	Boston	Massachusetts	02116	Recruiting
Seaport Investigator Site	Boston	Massachusetts	02131	Recruiting
Seaport Investigator Site	Russells Mills	Massachusetts	02747	Recruiting
Seaport Investigator Site	St Louis	Missouri	63141	Recruiting
Seaport Investigator Site	Brooklyn	New York	11235	Recruiting
Seaport Investigator Site	Cedarhurst	New York	11516	Recruiting
Seaport Investigator Site	New York	New York	10029	Recruiting
Seaport Investigator Site	Staten Island	New York	10314	Recruiting
Seaport Investigator Site	Independence	Ohio	44131	Recruiting
Seaport Investigator Site	North Canton	Ohio	44720	Recruiting
Seaport Investigator Site	Allentown	Pennsylvania	18104	Recruiting
Seaport Investigator Site	Dallas	Texas	75231	Recruiting
Seaport Investigator Site	Irving	Texas	75062	Recruiting
Seaport Investigator Site	Richardson	Texas	75080	Recruiting
Seaport Investigator Site	Everett	Washington	98201	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07065240, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 18, 2026 · Synced May 19, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07065240 live on ClinicalTrials.gov.

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