A Study to Learn About How a New Pneumococcal Vaccine Works in Adults
Public ClinicalTrials.gov record NCT07086677. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN STUDY TO DESCRIBE THE SAFETY AND TOLERABILITY OF A MULTIVALENT PNEUMOCOCCAL CONJUGATE VACCINE IN ADULTS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to two doses of study vaccine or comparator and take part in follow-up visits. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during clinic visits.
Study identification
- NCT ID
- NCT07086677
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 380 participants
Conditions and interventions
Conditions
Interventions
- PG4 vaccine in Buffer 1 with low dose PA-001 Biological
- PG4 in Buffer 1 with low dose PA-002 Biological
- PG4 in Buffer 1 with high dose PA-001 Biological
- PG4 vaccine in Buffer 1 with high dose PA-002 Biological
- PG4 vaccine in Buffer 2 Biological
- 20-valent pneumococcal conjugate vaccine Biological
- Saline injection Biological
Biological
Eligibility (public fields only)
- Age range
- 65 Years to 84 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 21, 2025
- Primary completion
- Oct 20, 2027
- Completion
- Oct 20, 2027
- Last update posted
- Jun 21, 2026
2025 – 2027
United States locations
- U.S. sites
- 20
- U.S. states
- 10
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Orange County Research Center | Lake Forest | California | 92630 | — |
| Peninsula Research Associates | Rolling Hills Estates | California | 90274 | — |
| Finlay Medical Research | Greenacres City | Florida | 33467 | — |
| Indago Research & Health Center, Inc. | Miami Lakes | Florida | 33016 | — |
| Johnson County Clinical Trials | Lenexa | Kansas | 66219 | — |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO | Springfield | Missouri | 65802 | — |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO-Screening and Recruitment Center | Springfield | Missouri | 65807 | — |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO | Springfield | Missouri | 65807 | — |
| Velocity Clinical Research, Omaha | Omaha | Nebraska | 68134 | — |
| Upstate Global Health Institute | East Syracuse | New York | 13057 | — |
| NYU Langone Health Vaccine Center | New York | New York | 10016 | — |
| Duke Vaccine and Trials Unit | Durham | North Carolina | 27703 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Headlands Horizons, LLC dba Headlands Research-Brownsville | Brownsville | Texas | 78526 | — |
| Valley Regional Medical Center | Brownsville | Texas | 78526 | — |
| LabCorp | Houston | Texas | 77064 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| Dynamed Clinical Research, LP d/b/a DM Clinical Research | Tomball | Texas | 77375 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic | Salt Lake City | Utah | 84109 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic South | Salt Lake City | Utah | 84121 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07086677, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 21, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07086677 live on ClinicalTrials.gov.