ClinicalTrials.gov record
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
ClinicalTrials.gov ID: NCT07157774
Public ClinicalTrials.gov record NCT07157774. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.
Study identification
- NCT ID
- NCT07157774
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 10,450 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 1, 2025
- Primary completion
- Feb 28, 2031
- Completion
- Feb 28, 2031
- Last update posted
- Sep 3, 2026
2025 – 2031
United States locations
- U.S. sites
- 159
- U.S. states
- 35
- U.S. cities
- 132
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham Clinical Research | Birmingham | Alabama | 35209 | Not yet recruiting |
| Smiths Medical Center | Apache Junction | Arizona | 85120 | Not yet recruiting |
| Phoenix Medical Trials | Gilbert | Arizona | 85295 | Not yet recruiting |
| Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC | Gilbert | Arizona | 85296 | Recruiting |
| Onyx Clinical Research | Phoenix | Arizona | 85014 | Recruiting |
| Clinical Research Institute of Arizona (CRI) - Sun City West | Sun City West | Arizona | 85375 | Recruiting |
| Southwest Kidney Institute - Surprise | Surprise | Arizona | 85374 | Recruiting |
| Pima Heart | Tucson | Arizona | 85741 | Recruiting |
| Eclipse Clinical Research | Tucson | Arizona | 85745 | Not yet recruiting |
| National Heart Institute | Beverly Hills | California | 90211 | Recruiting |
| John Muir Medical Center - Concord Campus | Concord | California | 94520 | Recruiting |
| Neighborhood Healthcare Institute of Health | Escondido | California | 92025 | Recruiting |
| Ark Clinical Research - Fountain Valley | Fountain Valley | California | 92708 | Recruiting |
| Thrive Clinical Research Group | Glendora | California | 91740 | Not yet recruiting |
| Care Access - Huntington Beach | Huntington Beach | California | 92648 | Recruiting |
| 310 Clinical Research | Inglewood | California | 90301 | Not yet recruiting |
| Scripps Whittier Diabetes Institute | La Jolla | California | 92037 | Not yet recruiting |
| The Cardiovascular Center | Redding | California | 96001 | Recruiting |
| FOMAT Medical Research - Santa Maria | Santa Maria | California | 93454 | Not yet recruiting |
| Integrated Clinical Research | Sherman Oaks | California | 91403 | Not yet recruiting |
| UCLA South Bay Endocrinology | Torrance | California | 90505 | Recruiting |
| Lynn Institute of Denver | Aurora | Colorado | 80012 | Not yet recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| Legacy Clinical Trials | Colorado Springs | Colorado | 80909 | Recruiting |
| OptumCare Clinical Trials, LLC | Golden | Colorado | 80401 | Completed |
| Cardiology Associates of Fairfield County, P.C. | Stamford | Connecticut | 06905 | Recruiting |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | Recruiting |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | Recruiting |
| FWD Clinical Research | Boca Raton | Florida | 33486 | Completed |
| American Research Institute | Cutler Bay | Florida | 33157 | Recruiting |
| K2 Medical Research - Daytona Beach | Daytona Beach | Florida | 32114 | Recruiting |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | Recruiting |
| Soffer Health Institute | Hollywood | Florida | 33020 | Recruiting |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | Recruiting |
| K2 MEDICAL Research THE VILLAGES | Lady Lake | Florida | 32159 | Recruiting |
| Clinical Research of Central Florida | Lakeland | Florida | 333805 | Not yet recruiting |
| K2 Medical Research - Maitland | Maitland | Florida | 32751 | Recruiting |
| K2 Medical Research ORLANDO | Maitland | Florida | 32751 | Recruiting |
| Dade Florida Clinical Research Center | Miami | Florida | 33173 | Recruiting |
| Onhealth Research Center | Miami | Florida | 33186 | Recruiting |
| Floridian Clinical Research, LLC | Miami Lakes | Florida | 33016-1518 | Not yet recruiting |
| Advanced Research for Health Improvement, LLC | Naples | Florida | 34102 | Recruiting |
| Renstar Medical Research | Ocala | Florida | 34471 | Recruiting |
| Florida Institute For Clinical Research, LLC | Orlando | Florida | 32825 | Not yet recruiting |
| Precision Clinical Research | Sunrise | Florida | 33351 | Not yet recruiting |
| Care Access - Tamarac | Tamarac | Florida | 33321 | Recruiting |
| Care Access - Tampa | Tampa | Florida | 33625 | Recruiting |
| Southeastern Clinical Research Institute | Augusta | Georgia | 30904 | Recruiting |
| Masters of Clinical Research | Augusta | Georgia | 30909 | Recruiting |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | Recruiting |
| NSC Research | Johns Creek | Georgia | 30024 | Not yet recruiting |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | Recruiting |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | Recruiting |
| CARE Institute - High Desert | Meridian | Idaho | 83642 | Recruiting |
| Elite Clinical Trials | Rexburg | Idaho | 83440 | Recruiting |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | Recruiting |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | Recruiting |
| Accellacare - DuPage | Lombard | Illinois | 60148 | Not yet recruiting |
| AMR Clinical | Niles | Illinois | 60714 | Recruiting |
| Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois | 62711 | Not yet recruiting |
| IU Health Bloomington | Bloomington | Indiana | 47408 | Recruiting |
| Indiana University Health Methodist Hospital | Indianapolis | Indiana | 46202 | Recruiting |
| Franciscan Physician Network - Indiana Heart Physicians | Indianapolis | Indiana | 46237 | Not yet recruiting |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | Not yet recruiting |
| Cotton O'Neil Clinical Research Center | Topeka | Kansas | 66606 | Not yet recruiting |
| Saint Elizabeth Healthcare - Saint Elizabeth Covington Hospital | Covington | Kentucky | 41011 | Not yet recruiting |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | Recruiting |
| MaineHealth Cardiology | Scarborough | Maine | 04074 | Recruiting |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | Recruiting |
| Metropolitan Cardiovascular Consultants | Beltsville | Maryland | 20750 | Recruiting |
| Flourish Research - Bowie | Bowie | Maryland | 20715 | Recruiting |
| Johns Hopkins University | Columbia | Maryland | 21044 | Recruiting |
| Centennial Medical Group | Columbia | Maryland | 21045 | Recruiting |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | Recruiting |
| Brigham and Women's Hospital Diabetes Program | Boston | Massachusetts | 02115 | Recruiting |
| Lucida Clinical Trials | New Bedford | Massachusetts | 02740 | Recruiting |
| Care Access - Quincy | Quincy | Massachusetts | 02169 | Recruiting |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | Recruiting |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | Recruiting |
| Boeson Research MSO | Missoula | Montana | 59804 | Recruiting |
| Desert Clinical Research, LLC | Henderson | Nevada | 89052 | Not yet recruiting |
| Clinical Research of South Nevada | Las Vegas | Nevada | 89121 | Recruiting |
| Vector Clinical Trials | Las Vegas | Nevada | 89128 | Recruiting |
| Renascor Clinical Research | Reno | Nevada | 89509 | Recruiting |
| Vector Clinical Trials | Sparks | Nevada | 89436 | Recruiting |
| Clinical Research of Philadelphia | Pennington | New Jersey | 08534 | Recruiting |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | Recruiting |
| IMA Clinical Research | Albuquerque | New Mexico | 87109 | Recruiting |
| Southwest Cardiovascular Center | Albuquerque | New Mexico | 87112 | Recruiting |
| Capital Cardiology Associates | Albany | New York | 12211 | Recruiting |
| Velocity Clinical Research, Syracuse | East Syracuse | New York | 13057 | Not yet recruiting |
| NYC Research | New York | New York | 10016 | Recruiting |
| Weill Cornell Medical College | New York | New York | 10021 | Recruiting |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | Recruiting |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | Recruiting |
| Southgate Medical Group | West Seneca | New York | 14224 | Recruiting |
| Care Access - Fayetteville | Fayetteville | North Carolina | 28314 | Recruiting |
| Medication Management | Greensboro | North Carolina | 27405 | Recruiting |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | Not yet recruiting |
| Accellacare - Raleigh | Raleigh | North Carolina | 27609 | Not yet recruiting |
| Velocity Clinical Research, Cincinnati, Mt. Auburn | Cincinnati | Ohio | 45219 | Not yet recruiting |
| Velocity Clinical Research, Cleveland | Cleveland | Ohio | 44122 | Not yet recruiting |
| Centricity Research Columbus Ohio Multispecialty | Columbus | Ohio | 43213 | Not yet recruiting |
| Kaiser Permanente Sunnyside Medical Center | Clackamas | Oregon | 97015 | Recruiting |
| Advanced Research Institute - Tigard | Portland | Oregon | 97223 | Recruiting |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | Recruiting |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | Recruiting |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | Recruiting |
| Abington Medical Specialists | Horsham | Pennsylvania | 19044 | Not yet recruiting |
| Penn Medicine: University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | Not yet recruiting |
| Clinical Research of Philadelphia | Philadelphia | Pennsylvania | 19114 | Recruiting |
| Keystone Clinical Studies | Plymouth Meeting | Pennsylvania | 19462 | Recruiting |
| Cardiology Consultants of Philadelphia Yardley | Yardley | Pennsylvania | 19067 | Not yet recruiting |
| M3 Wake Research - Charleston | Charleston | South Carolina | 29414 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Not yet recruiting |
| Walker Family Care | Little River | South Carolina | 29566 | Recruiting |
| Circle Clinical Research | Sioux Falls | South Dakota | 57104 | Recruiting |
| WR-Clinsearch, LLC | Chattanooga | Tennessee | 37397 | Recruiting |
| Erlanger Health System | Chattanooga | Tennessee | 37403 | Not yet recruiting |
| The Jackson Clinic | Jackson | Tennessee | 38305 | Recruiting |
| PharmaTex Research | Amarillo | Texas | 79106 | Recruiting |
| St. David's Heart & Vascular PLLC dba Austin Heart | Austin | Texas | 78756 | Recruiting |
| Velocity Clinical Research, Austin | Austin | Texas | 78759 | Not yet recruiting |
| Dallas VA Medical Center | Dallas | Texas | 75216 | Not yet recruiting |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | Recruiting |
| Renal Disease Research Institute | Dallas | Texas | 75246 | Recruiting |
| IntraCare | Dallas | Texas | 75254 | Recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Dallas Heart and Vascular Consultants, PA | Duncanville | Texas | 75137 | Not yet recruiting |
| Texas Health Research & Education Institute - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| Cedar Health Research - Fort Worth | Fort Worth | Texas | 76132 | Recruiting |
| Center for Cardiometabolic Disease Prevention/Baylor College of Medicine | Houston | Texas | 77030 | Recruiting |
| Orion Medical - Houston | Houston | Texas | 77034 | Not yet recruiting |
| Research Physicians Network, LLC | Houston | Texas | 77089 | Recruiting |
| GMG Clinical Research (DBA Radiance Clinical Research) - Lampasas | Lampasas | Texas | 76550 | Recruiting |
| Biopharma Informatic, LLC | McAllen | Texas | 78503 | Recruiting |
| Revival Research Institute, LLC | McKinney | Texas | 75071 | Recruiting |
| Texas Institute of Cardiology, PA | McKinney | Texas | 75071 | Not yet recruiting |
| PRX Research | Mesquite | Texas | 75149 | Recruiting |
| ERA Health Research-Texas | Midland | Texas | 79707 | Recruiting |
| Sherman Clinical Research | Sherman | Texas | 75090 | Recruiting |
| Intermountain Medical Center | Murray | Utah | 84107 | Recruiting |
| Ogden Clinic - Canyon View | Ogden | Utah | 84404 | Recruiting |
| Advanced Research Institute | Ogden | Utah | 84405 | Recruiting |
| Virginia Heart | Falls Church | Virginia | 22042 | Recruiting |
| Mary Washington Hospital | Fredericksburg | Virginia | 22401 | Not yet recruiting |
| Carient Heart & Vascular - Manassas | Manassas | Virginia | 20109 | Recruiting |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | Recruiting |
| TPMG (Tidewater Physicians Multispecialty Group) Clinical Research | Newport News | Virginia | 23606 | Recruiting |
| York Clinical Research | Norfolk | Virginia | 23504 | Recruiting |
| Carient Heart and Vascular LLC-Reston | Reston | Virginia | 20190 | Not yet recruiting |
| Dominion Medical Associates, Inc. | Richmond | Virginia | 23219 | Recruiting |
| Carilion Clinic | Roanoke | Virginia | 24014 | Recruiting |
| ERA Health Research - CardioNow - Lynnwood | Lynnwood | Washington | 98036 | Recruiting |
| Eastside Research Associates | Redmond | Washington | 98052 | Recruiting |
| Rainier Clinical Research Center | Renton | Washington | 98057 | Recruiting |
| Universal Research Group | Tacoma | Washington | 98405 | Recruiting |
| Central Washington Health Services Association d/b/a Confluence Health | Wenatchee | Washington | 98801 | Recruiting |
| Clinical Investigation Specialists | Kenosha | Wisconsin | 53144 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 634 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07157774, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 3, 2026 · Synced Sep 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07157774 live on ClinicalTrials.gov.