Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

ClinicalTrials.gov ID: NCT07157774

Public ClinicalTrials.gov record NCT07157774. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 19, 2026, 3:47 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event

Study identification

NCT ID: NCT07157774
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 10,450 participants

Conditions and interventions

Conditions

Interventions

Muvalaplin Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 1, 2025
Primary completion: Feb 28, 2031
Completion: Feb 28, 2031
Last update posted: May 18, 2026

2025 – 2031

United States locations

U.S. sites: 121
U.S. states: 30
U.S. cities: 102

Facility	City	State	ZIP	Site status
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC	Gilbert	Arizona	85296	Recruiting
Axsendo Clinical Research - Peak Heart & Vascular - Phoenix	Phoenix	Arizona	85014	Recruiting
Clinical Research Institute of Arizona (CRI) - Sun City West	Sun City West	Arizona	85375	Recruiting
Southwest Kidney Institute - Surprise	Surprise	Arizona	85374	Recruiting
Pima Heart	Tucson	Arizona	85741	Not yet recruiting
National Heart Institute	Beverly Hills	California	90211	Recruiting
John Muir Medical Center - Concord Campus	Concord	California	94520	Recruiting
Neighborhood Healthcare Institute of Health	Escondido	California	92025	Recruiting
Ark Clinical Research - Fountain Valley	Fountain Valley	California	92708	Recruiting
Care Access - Huntington Beach	Huntington Beach	California	92648	Not yet recruiting
The Cardiovascular Center	Redding	California	96001	Recruiting
UCLA South Bay Endocrinology	Torrance	California	90505	Recruiting
University of Colorado Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Legacy Clinical Trials	Colorado Springs	Colorado	80909	Recruiting
OptumCare Clinical Trials, LLC	Golden	Colorado	80401	Not yet recruiting
Cardiology Associates of Fairfield County, P.C.	Stamford	Connecticut	06905	Not yet recruiting
Chase Medical Research, LLC	Waterbury	Connecticut	06708	Not yet recruiting
Excel Medical Clinical Trials	Boca Raton	Florida	33434	Recruiting
FWD Clinical Research	Boca Raton	Florida	33486	Not yet recruiting
American Research Institute	Cutler Bay	Florida	33157	Recruiting
K2 Medical Research - Daytona Beach	Daytona Beach	Florida	32114	Recruiting
Arrow Clinical Trials	Daytona Beach	Florida	32117	Recruiting
Soffer Health Institute	Hollywood	Florida	33020	Recruiting
Jacksonville Center for Clinical Research	Jacksonville	Florida	32216	Not yet recruiting
K2 MEDICAL Research THE VILLAGES	Lady Lake	Florida	32159	Recruiting
K2 Medical Research - Maitland	Maitland	Florida	32751	Recruiting
K2 Medical Research ORLANDO	Maitland	Florida	32751	Recruiting
Dade Florida Clinical Research Center	Miami	Florida	33173	Recruiting
Onhealth Research Center	Miami	Florida	33186	Recruiting
Advanced Research for Health Improvement, LLC	Naples	Florida	34102	Recruiting
Renstar Medical Research	Ocala	Florida	34471	Recruiting
Care Access - Tamarac	Tamarac	Florida	33321	Recruiting
Care Access - Tampa	Tampa	Florida	33625	Recruiting
Southeastern Clinical Research Institute	Augusta	Georgia	30904	Not yet recruiting
Masters of Clinical Research	Augusta	Georgia	30909	Recruiting
Center for Advanced Research & Education	Gainesville	Georgia	30501	Not yet recruiting
North Georgia Clinical Research	Woodstock	Georgia	30189	Recruiting
Elite Clinical Trials	Blackfoot	Idaho	83221	Recruiting
CARE Institute - High Desert	Meridian	Idaho	83642	Recruiting
Elite Clinical Trials	Rexburg	Idaho	83440	Recruiting
Great Lakes Clinical Trials - Ravenswood	Chicago	Illinois	60640	Recruiting
AMR Clinical	Niles	Illinois	60714	Not yet recruiting
IU Health Bloomington	Bloomington	Indiana	47408	Not yet recruiting
Indiana University Health Methodist Hospital	Indianapolis	Indiana	46202	Not yet recruiting
Tulane University School of Medicine	New Orleans	Louisiana	70112	Not yet recruiting
MaineHealth Cardiology	Scarborough	Maine	04074	Recruiting
Ascension Saint Agnes Heart Care	Baltimore	Maryland	21229	Recruiting
Metropolitan Cardiovascular Consultants	Beltsville	Maryland	20750	Not yet recruiting
Flourish Research - Bowie	Bowie	Maryland	20715	Recruiting
Johns Hopkins University	Columbia	Maryland	21044	Recruiting
Centennial Medical Group	Columbia	Maryland	21045	Recruiting
Anderson Medical Research	Ft. Washington	Maryland	20744	Recruiting
Brigham and Women's Hospital Diabetes Program	Boston	Massachusetts	02115	Not yet recruiting
Lucida Clinical Trials	New Bedford	Massachusetts	02740	Recruiting
Care Access - Quincy	Quincy	Massachusetts	02169	Recruiting
Revival Research Institute, LLC	Dearborn	Michigan	48126	Recruiting
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division	Troy	Michigan	48098	Recruiting
Boeson Research MSO	Missoula	Montana	59804	Recruiting
Clinical Research of South Nevada	Las Vegas	Nevada	89121	Recruiting
Vector Clinical Trials	Las Vegas	Nevada	89128	Recruiting
Vector Clinical Trials	Sparks	Nevada	89436	Recruiting
Clinical Research of Philadelphia	Pennington	New Jersey	08534	Not yet recruiting
Cardio Metabolic Institute	Somerset	New Jersey	08873	Not yet recruiting
IMA Clinical Research	Albuquerque	New Mexico	87109	Recruiting
Southwest Cardiovascular Center	Albuquerque	New Mexico	87112	Recruiting
Capital Cardiology Associates	Albany	New York	12211	Recruiting
NYC Research	New York	New York	10016	Recruiting
Weill Cornell Medical College	New York	New York	10021	Recruiting
Rochester Clinical Research, LLC	Rochester	New York	14609	Recruiting
SUNY Upstate Medical University	Syracuse	New York	13210	Not yet recruiting
Southgate Medical Group	West Seneca	New York	14224	Recruiting
Care Access - Fayetteville	Fayetteville	North Carolina	28314	Recruiting
Medication Management	Greensboro	North Carolina	27405	Recruiting
Kaiser Permanente Sunnyside Medical Center	Clackamas	Oregon	97015	Recruiting
Advanced Research Institute - Tigard	Tigard	Oregon	97223	Recruiting
Lehigh Valley Health Network	Allentown	Pennsylvania	18103	Not yet recruiting
Capital Area Research, LLC	Camp Hill	Pennsylvania	17011	Recruiting
Altoona Center For Clinical Research	Duncansville	Pennsylvania	16635	Recruiting
Penn Medicine: University of Pennsylvania Health System	Philadelphia	Pennsylvania	19104	Not yet recruiting
Clinical Research of Philadelphia	Philadelphia	Pennsylvania	19114	Not yet recruiting
Keystone Clinical Studies	Plymouth Meeting	Pennsylvania	19462	Not yet recruiting
M3 Wake Research - Charleston	Charleston	South Carolina	29414	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Not yet recruiting
Walker Family Care	Little River	South Carolina	29566	Recruiting
Circle Clinical Research	Sioux Falls	South Dakota	57104	Recruiting
WR-Clinsearch, LLC	Chattanooga	Tennessee	37397	Recruiting
The Jackson Clinic	Jackson	Tennessee	38305	Recruiting
PharmaTex Research	Amarillo	Texas	79106	Recruiting
St. David's Heart & Vascular PLLC dba Austin Heart	Austin	Texas	78756	Recruiting
Dallas VA Medical Center	Dallas	Texas	75216	Not yet recruiting
Southwest Family Medicine Associates	Dallas	Texas	75235	Recruiting
Renal Disease Research Institute	Dallas	Texas	75246	Recruiting
IntraCare	Dallas	Texas	75254	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75390	Not yet recruiting
Texas Health Research & Education Institute - Fort Worth	Fort Worth	Texas	76104	Recruiting
Cedar Health Research - Fort Worth	Fort Worth	Texas	76132	Recruiting
Center for Cardiometabolic Disease Prevention/Baylor College of Medicine	Houston	Texas	77030	Not yet recruiting
Research Physicians Network, LLC	Houston	Texas	77089	Recruiting
GMG Clinical Research (DBA Radiance Clinical Research) - Lampasas	Lampasas	Texas	76550	Recruiting
Biopharma Informatic, LLC	McAllen	Texas	78503	Not yet recruiting
Revival Research Institute, LLC	McKinney	Texas	75071	Recruiting
PRX Research	Mesquite	Texas	75149	Recruiting
ERA Health Research-Texas	Midland	Texas	79707	Recruiting
Sherman Clinical Research	Sherman	Texas	75090	Recruiting
Intermountain Medical Center	Murray	Utah	84107	Not yet recruiting
Ogden Clinic - Canyon View	Ogden	Utah	84404	Recruiting
Advanced Research Institute	Ogden	Utah	84405	Recruiting
Virginia Heart	Falls Church	Virginia	22042	Recruiting
Mary Washington Hospital	Fredericksburg	Virginia	22401	Not yet recruiting
Carient Heart & Vascular - Manassas	Manassas	Virginia	20109	Recruiting
Manassas Clinical Research Center	Manassas	Virginia	20110	Recruiting
TPMG (Tidewater Physicians Multispecialty Group) Clinical Research	Newport News	Virginia	23606	Recruiting
York Clinical Research	Norfolk	Virginia	23504	Recruiting
Dominion Medical Associates, Inc.	Richmond	Virginia	23219	Recruiting
Carilion Clinic	Roanoke	Virginia	24014	Recruiting
ERA Health Research - CardioNow - Lynnwood	Lynnwood	Washington	98036	Recruiting
Eastside Research Associates	Redmond	Washington	98052	Recruiting
Rainier Clinical Research Center	Renton	Washington	98057	Recruiting
Universal Research Group	Tacoma	Washington	98405	Recruiting
Central Washington Health Services Association d/b/a Confluence Health	Wenatchee	Washington	98801	Recruiting
Clinical Investigation Specialists	Kenosha	Wisconsin	53144	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 623 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07157774, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 18, 2026 · Synced May 19, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07157774 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →