ClinicalTrials.gov record
A Study to Evaluate the Safety and Efficacy of MK-1406/CD388 for Prevention of Influenza (MK-1406-005/CD388.SQ.3.06)
ClinicalTrials.gov ID: NCT07159763
Public ClinicalTrials.gov record NCT07159763. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of CD388, a Novel Long-Acting Antiviral Conjugate, for the Prevention of Influenza in Adults and Adolescents at Higher Risk of Developing Influenza Complications
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Approximately one billion cases of seasonal influenza occur annually. Of these, 3 to 5 million illnesses are severe and responsible for up to 650,000 deaths per year (WHO 2025). Yearly administration of an influenza vaccine for the prevention of influenza is currently recommended. However, the real-world vaccine effectiveness varied from 10% to 60% in the general population across the years of 2004 to 2024, with effectiveness in most years below 50% (CDC 2025) and decreasing to as low as 5% in immunocompromised individuals (Hughes 2021). The goal of this study is to learn whether MK-1406 (CD388) can help prevent the flu in people who are at higher risk of becoming seriously ill from influenza. Researchers want to find out if MK-1406 dosed at a single study visit can provide protection against influenza compared with placebo. The study will include adolescents and adults who may be more vulnerable to complications from influenza because of their age, health conditions, or weakened immune systems. Researchers will also evaluate the safety of MK-1406 and how well participants tolerate the study medicine.
Study identification
- NCT ID
- NCT07159763
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- Industry
- Enrollment
- 10,000 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 25, 2025 (Actual)
- Primary completion
- Jun 30, 2027 (Estimated)
- Completion
- Jun 30, 2027 (Estimated)
- Last update posted
- Oct 15, 2026
2025 – 2027
United States locations
- U.S. sites
- 120
- U.S. states
- 36
- U.S. cities
- 107
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group ( Site 0505) | Anniston | Alabama | 36207 | Recruiting |
| Cullman Clinical Trials ( Site 0538) | Cullman | Alabama | 35055 | Recruiting |
| Hope Research Institute ( Site 0575) | Glendale | Arizona | 85308 | Recruiting |
| Desert Clinical Research/ CCT Research ( Site 0612) | Mesa | Arizona | 85213 | Active, not recruiting |
| Foothills Research Center ( Site 0591) | Phoenix | Arizona | 85044 | Active, not recruiting |
| Fiel Family and Sports Medicine, PC/CCT Research ( Site 0529) | Tempe | Arizona | 85283 | Active, not recruiting |
| Hope Research Institute ( Site 0587) | Tempe | Arizona | 85284 | Recruiting |
| Arizona Liver Health ( Site 0516) | Tucson | Arizona | 85712 | Active, not recruiting |
| Del Sol Research Management, LLC ( Site 0515) | Tucson | Arizona | 85715 | Recruiting |
| Triallogix Medical Corporation ( Site 0615) | Fullerton | California | 92835 | Recruiting |
| National Institute of Clinical Research ( Site 0582) | Garden Grove | California | 92844 | Active, not recruiting |
| Eximia Clinical Research ( Site 0571) | La Mesa | California | 91942 | Active, not recruiting |
| Long Beach Clinical Trials, LLC ( Site 0607) | Long Beach | California | 90806 | Active, not recruiting |
| Profound Research LLC ( Site 0533) | Oceanside | California | 92058 | Active, not recruiting |
| Profound Research LLC ( Site 0574) | Pasadena | California | 91105 | Recruiting |
| Paradigm Clinical Research Centers, Inc ( Site 0518) | Redding | California | 96001 | Recruiting |
| Artemis Institute for Clinical Research ( Site 0617) | San Diego | California | 92103 | Active, not recruiting |
| Acclaim Clinical Research ( Site 0506) | San Diego | California | 92120 | Active, not recruiting |
| Diablo Clinical Research, Inc. ( Site 0572) | Walnut Creek | California | 94598 | Active, not recruiting |
| Tekton Research ( Site 0611) | Denver | Colorado | 80238 | Recruiting |
| Tekton Research ( Site 0613) | Fort Collins | Colorado | 80528 | Active, not recruiting |
| Critical Care Pulmonary & Sleep Associates - CCT Research ( Site 0525) | Lakewood | Colorado | 80228 | Recruiting |
| Tekton Research, LLC. ( Site 0616) | Longmont | Colorado | 80501 | Active, not recruiting |
| New England Research Associates, LLC ( Site 0558) | Bridgeport | Connecticut | 06606 | Recruiting |
| Stamford Therapeutics Consortium ( Site 0539) | Stamford | Connecticut | 06905 | Active, not recruiting |
| Emerson Clinical Research Institute ( Site 0547) | Washington D.C. | District of Columbia | 20009 | Active, not recruiting |
| Imagine Research of Palm Beach County ( Site 0509) | Boynton Beach | Florida | 33435 | Active, not recruiting |
| Innovative Research of West Florida ( Site 0596) | Clearwater | Florida | 33756 | Active, not recruiting |
| Hillcrest Medical Research ( Site 0563) | DeLand | Florida | 32720 | Active, not recruiting |
| Health Awareness, Inc. ( Site 0524) | Jupiter | Florida | 33458 | Recruiting |
| Columbus Clinical Services ( Site 0588) | Miami | Florida | 33125 | Active, not recruiting |
| South Florida Research Center, Inc ( Site 0507) | Miami | Florida | 33135 | Active, not recruiting |
| Clinical Site Partners, LLC d/b/a CSP Miami ( Site 0521) | Miami | Florida | 33186 | Active, not recruiting |
| Floridian Clinical Research, LLC ( Site 0534) | Miami Lakes | Florida | 33016 | Recruiting |
| Behavioral Clinical Research, Inc. ( Site 0508) | North Miami | Florida | 33161 | Active, not recruiting |
| Clinical Neuroscience Solutions ( Site 0623) | Orlando | Florida | 32806 | Active, not recruiting |
| Progressive Medical Research ( Site 0579) | Port Orange | Florida | 32127 | Recruiting |
| Health Awareness, Inc. ( Site 0541) | Port Saint Lucie | Florida | 34952 | Recruiting |
| GCP- Global Clinical Research Professionals, LLC ( Site 0595) | St. Petersburg | Florida | 33714 | Recruiting |
| Clinical Site Partners, LLC dba Flourish Research ( Site 0540) | Winter Park | Florida | 32789 | Recruiting |
| Agile Clinical Research Trials, LLC ( Site 0600) | Atlanta | Georgia | 30328 | Recruiting |
| DelRicht Research ( Site 0583) | Atlanta | Georgia | 30329 | Recruiting |
| Clinical Research Atlanta ( Site 0531) | Stockbridge | Georgia | 30281 | Recruiting |
| Paradigm Clinical Research - Boise ( Site 0614) | Boise | Idaho | 83709 | Recruiting |
| Velocity Clinical Research, Boise ( Site 0535) | Meridian | Idaho | 83642 | Recruiting |
| Great Lakes Clinical Trials - Ravenswood ( Site 0564) | Chicago | Illinois | 60640 | Recruiting |
| DM Clinical Research ( Site 0502) | Palos Heights | Illinois | 60463 | Recruiting |
| Velocity Clinical Research ( Site 0528) | Valparaiso | Indiana | 46383 | Active, not recruiting |
| Integrated Clinical Trial Services, Inc ( Site 0576) | West Des Moines | Iowa | 50265 | Recruiting |
| Johnson County Clin-Trials ( Site 0530) | Lenexa | Kansas | 66219-1376 | Recruiting |
| Alliance for Multispecialty Research, LLC ( Site 0561) | Newton | Kansas | 67114 | Recruiting |
| DelRicht Research ( Site 0585) | Louisville | Kentucky | 40205 | Active, not recruiting |
| Elevate Clinical Research ( Site 0565) | Lake Charles | Louisiana | 70605 | Active, not recruiting |
| DelRicht Research ( Site 0510) | New Orleans | Louisiana | 70115 | Active, not recruiting |
| DelRicht Research ( Site 0594) | Prairieville | Louisiana | 70769-4212 | Recruiting |
| Annapolis Internal Medicine - CCT Research ( Site 0580) | Annapolis | Maryland | 21401 | Recruiting |
| Jadestone Clinical Research, LLC ( Site 0555) | Silver Spring | Maryland | 20904 | Active, not recruiting |
| Skylight Health Research, Inc ( Site 0609) | Burlington | Massachusetts | 01803 | Recruiting |
| Profound Research LLC ( Site 0536) | Clarkston | Michigan | 48346 | Active, not recruiting |
| Michigan Hematology & Oncology Consultants ( Site 0610) | Dearborn | Michigan | 48126 | Recruiting |
| Michigan Heathcare Professionals- TRIATRIA ( Site 0513) | Farmington Hills | Michigan | 48334 | Active, not recruiting |
| Mankato Clinic ( Site 0573) | Mankato | Minnesota | 56001 | Recruiting |
| DelRicht Research ( Site 0584) | Gulfport | Mississippi | 39503 | Recruiting |
| Clay- Platte Family Medicine, P.C.-CCT Research ( Site 0517) | Kansas City | Missouri | 64151 | Active, not recruiting |
| DelRicht Research ( Site 0586) | Springfield | Missouri | 65807 | Active, not recruiting |
| Sundance Clinical Research LLC ( Site 0526) | St Louis | Missouri | 63141 | Recruiting |
| Montana Medical Research, Inc. ( Site 0570) | Missoula | Montana | 59808 | Active, not recruiting |
| Methodist Physicians Clinic/CCT Research ( Site 0598) | Fremont | Nebraska | 68025 | Recruiting |
| Velocity Clinical Research, Omaha ( Site 0512) | Omaha | Nebraska | 68134 | Active, not recruiting |
| Midwest Regional Health Services, LLC / Avacare ( Site 0603) | Omaha | Nebraska | 68144 | Recruiting |
| Henderson Clinical Trials ( Site 0522) | Henderson | Nevada | 89052 | Active, not recruiting |
| Excel Clinical Research, LLC ( Site 0566) | Las Vegas | Nevada | 89109 | Recruiting |
| Santa Rosa Medical Centers of Nevada / CCT Research ( Site 0605) | Las Vegas | Nevada | 89119 | Recruiting |
| Las Vegas Clinical Trials ( Site 0527) | North Las Vegas | Nevada | 89030 | Active, not recruiting |
| IMA Clinical Research ( Site 0599) | Warren Township | New Jersey | 07059 | Active, not recruiting |
| DM Clinical Research - Brooklyn ( Site 0550) | Brooklyn | New York | 11226 | Recruiting |
| Certified Research Associates ( Site 0552) | Cortland | New York | 13045 | Active, not recruiting |
| Drug Trials America ( Site 0553) | Hartsdale | New York | 10530 | Active, not recruiting |
| Rochester Clinical Research, Inc. ( Site 0557) | Rochester | New York | 14609 | Active, not recruiting |
| CHEAR Center LLC ( Site 0543) | The Bronx | New York | 10455 | Active, not recruiting |
| DelRicht Research ( Site 0593) | Charlotte | North Carolina | 28210 | Active, not recruiting |
| Eximia EquiHealth Research ( Site 0590) | Durham | North Carolina | 27704 | Active, not recruiting |
| Monroe Biomedical Research ( Site 0549) | Monroe | North Carolina | 28112 | Active, not recruiting |
| West Clinical Research ( Site 0542) | Morehead City | North Carolina | 28557 | Active, not recruiting |
| OnSite Clinical Solutions ( Site 0608) | Salisbury | North Carolina | 28144 | Active, not recruiting |
| Wilmington Health Associates ( Site 0548) | Wilmington | North Carolina | 28401 | Recruiting |
| Wake Forest University Health Sciences ( Site 0569) | Winston-Salem | North Carolina | 27157 | Recruiting |
| Velocity Clinical Research, Springdale ( Site 0511) | Cincinnati | Ohio | 45246 | Active, not recruiting |
| Velocity Clinical Research- Cleveland ( Site 0520) | Cleveland | Ohio | 44122 | Active, not recruiting |
| Centricity Research Columbus Ohio Multispecialty ( Site 0562) | Columbus | Ohio | 43213 | Active, not recruiting |
| PriMED Clinical Research ( Site 0560) | Dayton | Ohio | 45429 | Recruiting |
| Tekton Research, LLC. ( Site 0601) | Edmond | Oklahoma | 73013 | Recruiting |
| Lynn Health Science Institute - East (OKC) ( Site 0544) | Oklahoma City | Oklahoma | 73111 | Active, not recruiting |
| DelRicht Research ( Site 0618) | Tulsa | Oklahoma | 74133 | Recruiting |
| Tekton Research, Inc. ( Site 0597) | Yukon | Oklahoma | 73099 | Active, not recruiting |
| Altoona Center for Clinical Research ( Site 0545) | Duncansville | Pennsylvania | 16635 | Active, not recruiting |
| Liberty Family Practice ( Site 0546) | Erie | Pennsylvania | 16508 | Recruiting |
| Hatboro Medical Associates ( Site 0551) | Horsham | Pennsylvania | 19044 | Active, not recruiting |
| DelRicht Research ( Site 0619) | Charleston | South Carolina | 29407 | Active, not recruiting |
| Tribe Clinical Research, LLC ( Site 0577) | Greenville | South Carolina | 29607 | Recruiting |
| Spartanburg Medical Research ( Site 0514) | Spartanburg | South Carolina | 29303 | Recruiting |
| Velocity Clinical Research, Spartanburg ( Site 0523) | Spartanburg | South Carolina | 29303 | Active, not recruiting |
| DelRicht Research ( Site 0620) | Hendersonville | Tennessee | 37075 | Active, not recruiting |
| DCT-HCWC, LLC dba Discovery Clinical Trials ( Site 0606) | Dallas | Texas | 75230 | Recruiting |
| Zenos Clinical Research ( Site 0537) | Dallas | Texas | 75230 | Active, not recruiting |
| Lonestar Clinical Research - Dallas ( Site 0501) | Dallas | Texas | 75243 | Active, not recruiting |
| Elevate Clinical Research - Houston ( Site 0589) | Houston | Texas | 77058 | Recruiting |
| DM Clinical Research ( Site 0503) | Houston | Texas | 77065 | Active, not recruiting |
| Laguna Clinical Research Associates LLC ( Site 0581) | Laredo | Texas | 78041 | Active, not recruiting |
| Epic Clinical Research ( Site 0578) | Lewisville | Texas | 75057 | Active, not recruiting |
| Elevate Clinical Research - McAllen ( Site 0621) | McAllen | Texas | 78504 | Active, not recruiting |
| Pearland Physicians ( Site 0592) | Pearland | Texas | 77581 | Active, not recruiting |
| Javara - Privia Medical Group North Texas - Dallas ( Site 0519) | Plano | Texas | 75093 | Active, not recruiting |
| Research Your Health ( Site 0567) | Plano | Texas | 75093 | Recruiting |
| Clinical Trials of Texas, LLC ( Site 0532) | San Antonio | Texas | 78229 | Active, not recruiting |
| Cope Family Medicine / CCT Research ( Site 0602) | Bountiful | Utah | 84010 | Active, not recruiting |
| Olympus Family Medicine/CCT Research ( Site 0604) | Salt Lake City | Utah | 84117 | Active, not recruiting |
| Charlottesville Medical Research ( Site 0559) | Charlottesville | Virginia | 22911 | Recruiting |
| Clinical Research Partners, LLC. ( Site 0504) | Richmond | Virginia | 23226 | Recruiting |
| Rainier Clinical Research Center ( Site 0556) | Renton | Washington | 98057 | Active, not recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 61 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07159763, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07159763 live on ClinicalTrials.gov.