An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)
Public ClinicalTrials.gov record NCT07161700. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 6-Week, Multicenter, Open-Label, Monotherapy, Extension Study of SPT-300 in Adults With Major Depressive Disorder, With or Without Anxious Distress
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an open-label, monotherapy, extension study to evaluate the safety and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without anxious distress.
Study identification
- NCT ID
- NCT07161700
- Recruitment status
- Enrolling by invitation
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 360 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 66 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2, 2025 (Actual)
- Primary completion
- May 2027 (Estimated)
- Completion
- May 2027 (Estimated)
- Last update posted
- Oct 6, 2026
2025 – 2027
United States locations
- U.S. sites
- 20
- U.S. states
- 9
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Seaport Investigator Site | Chino | California | 91710 | — |
| Seaport Investigator Site | Garden Grove | California | 92845-2506 | — |
| Seaport Investigator Site | Glendale | California | 91206 | — |
| Seaport Investigator Site | San Jose | California | 95124 | — |
| Seaport Investigator Site | Cromwell | Connecticut | 06416 | — |
| Seaport Investigator Site | Lauderhill | Florida | 33319 | — |
| Seaport Investigator Site | Palm Bay | Florida | 32905 | — |
| Seaport Investigator Site | West Palm Beach | Florida | 33407 | — |
| Seaport Investigator Site | Atlanta | Georgia | 30328 | — |
| Seaport Investigator Site | Decatur | Georgia | 30030 | — |
| Seaport Investigator Site | Boston | Massachusetts | 02116 | — |
| Seaport Investigator Site | St Louis | Missouri | 63141 | — |
| Seaport Investigator Site | Brooklyn | New York | 11235 | — |
| Seaport Investigator Site | Cedarhurst | New York | 11516 | — |
| Seaport Investigator Site | New York | New York | 10029 | — |
| Seaport Investigator Site | Staten Island | New York | 10314 | — |
| Seaport Investigator Site | Independence | Ohio | 44131 | — |
| Seaport Investigator Site | North Canton | Ohio | 44720 | — |
| Seaport Investigator Site | Irving | Texas | 75062 | — |
| Seaport Investigator Site | Richardson | Texas | 75080 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07161700, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2026 · Synced Nov 1, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07161700 live on ClinicalTrials.gov.