ClinicalTrials.gov record
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
ClinicalTrials.gov ID: NCT07165028
Public ClinicalTrials.gov record NCT07165028. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:59 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes
Study identification
- NCT ID
- NCT07165028
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 4,500 participants
Conditions and interventions
Interventions
- Placebo Drug
- Retatrutide Drug
- Tirzepatide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 14, 2025
- Primary completion
- Jul 31, 2030
- Completion
- Jul 31, 2032
- Last update posted
- Apr 16, 2026
2025 – 2032
United States locations
- U.S. sites
- 140
- U.S. states
- 34
- U.S. cities
- 125
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MFA Clinical Research | Tuscaloosa | Alabama | 35405 | Not yet recruiting |
| The Institute for Liver Health II dba Arizona Clinical Trials - Chandler | Chandler | Arizona | 85224 | Recruiting |
| Spectrum Research Institute | Gilbert | Arizona | 85297 | Recruiting |
| The Institute for Liver Health II dba Arizona Liver Health - Peoria | Peoria | Arizona | 85381 | Recruiting |
| Epic Medical Research-Sun City | Sun City | Arizona | 85351 | Recruiting |
| The Institute for Liver Health II dba Arizona Clinical Trials - Tucson | Tucson | Arizona | 85712 | Recruiting |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | Recruiting |
| Arkansas Gastroenterology - North Little Rock | North Little Rock | Arkansas | 72117 | Recruiting |
| San Fernando Valley Health Institute | Canoga Park | California | 91304 | Recruiting |
| Ark Clinical Research - Fountain Valley | Fountain Valley | California | 92708 | Recruiting |
| Fresno Clinical Research Center | Fresno | California | 93720 | Recruiting |
| UCSD - Altman Clinical and Translational Research Institute (ACTRI) | La Jolla | California | 92037 | Not yet recruiting |
| Orange County Research Center | Lake Forest | California | 92630 | Not yet recruiting |
| Om Research LLC | Lancaster | California | 93534 | Recruiting |
| Ark Clinical Research | Long Beach | California | 90815 | Recruiting |
| Los Angeles Institute for Metabolic Research | Los Angeles | California | 90015 | Recruiting |
| United Medical Doctors - Murrieta | Murrieta | California | 92563 | Recruiting |
| Knowledge Research Center | Orange | California | 92868 | Recruiting |
| California Liver Research Center | Pasadena | California | 91105 | Recruiting |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | Recruiting |
| Medical Associates Research Group | San Diego | California | 92123 | Recruiting |
| Quest Clinical Research | San Francisco | California | 94115 | Not yet recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Not yet recruiting |
| South Denver Gastroenterology | Englewood | Colorado | 80113 | Recruiting |
| Medical Research Center of Connecticut | Hamden | Connecticut | 06518 | Not yet recruiting |
| K2 Medical Research WINTER GARDEN | Clermont | Florida | 34711 | Recruiting |
| K2 Medical Research - Daytona Beach | Daytona Beach | Florida | 32114 | Recruiting |
| Care Access - Delray Beach | Delray Beach | Florida | 33484 | Recruiting |
| AMR Clinical | Doral | Florida | 33172 | Recruiting |
| Southwest General Healthcare Center | Fort Myers | Florida | 33907 | Recruiting |
| University of Florida College of Medicine | Gainesville | Florida | 32610 | Not yet recruiting |
| Encore Medical Research | Hollywood | Florida | 33024 | Recruiting |
| Nature Coast Clinical Research - Inverness | Inverness | Florida | 34452 | Recruiting |
| Encore Borland-Groover Clinical Research | Jacksonville | Florida | 32256 | Recruiting |
| Health Awareness | Jupiter | Florida | 33458 | Recruiting |
| K2 MEDICAL Research THE VILLAGES | Lady Lake | Florida | 32159 | Recruiting |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | Recruiting |
| Tampa Bay Medical Research - Largo | Largo | Florida | 33777 | Recruiting |
| Evolution Clinical Trials | Miami | Florida | 33122-1722 | Recruiting |
| Floridian Clinical Research, LLC | Miami Lakes | Florida | 33016-1518 | Recruiting |
| GI PROS Research | Naples | Florida | 34102 | Recruiting |
| Charter Research - Orlando | Orlando | Florida | 32803 | Recruiting |
| Headlands Research Orlando | Orlando | Florida | 32806 | Recruiting |
| Progressive Medical Research | Port Orange | Florida | 32127 | Recruiting |
| Covenant Metabolic Specialists - Riverview | Riverview | Florida | 33578 | Recruiting |
| Care Access - St. Petersburg | St. Petersburg | Florida | 33710 | Recruiting |
| Care Access - Tamarac | Tamarac | Florida | 33321 | Recruiting |
| Covenant Metabolic Specialists, LLC | University Park | Florida | 34201 | Recruiting |
| Southeast Clinical Research Center | Dalton | Georgia | 30720 | Recruiting |
| Teak Research Consults | Lawrenceville | Georgia | 30043 | Not yet recruiting |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | Recruiting |
| Rophe Adult and Pediatric Medicine/SKYCRNG | Union City | Georgia | 30291 | Not yet recruiting |
| Indiana University Health University Hospital | Indianapolis | Indiana | 46202 | Recruiting |
| Gastroenterology Health Partners | New Albany | Indiana | 47150 | Not yet recruiting |
| Deaconess Clinic- Gateway | Newburgh | Indiana | 47630 | Not yet recruiting |
| Digestive Research Alliance of Michiana | South Bend | Indiana | 46635 | Recruiting |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | Recruiting |
| AMR Clinical | El Dorado | Kansas | 67042 | Recruiting |
| Johnson County Clinical Trials | Lenexa | Kansas | 66219 | Recruiting |
| Cotton O'Neil Digestive Health Center | Topeka | Kansas | 66606 | Recruiting |
| AMR Clinical | Lexington | Kentucky | 40509 | Recruiting |
| Delta Research Partners of Bastrop, LLC | Bastrop | Louisiana | 71220 | Recruiting |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | Recruiting |
| Care Access - New Iberia | New Iberia | Louisiana | 70560 | Recruiting |
| Louisiana Research Center | Shreveport | Louisiana | 71105 | Recruiting |
| Delta Research Partners of West Monroe | West Monroe | Louisiana | 71291 | Recruiting |
| Mercy Medical Center - Baltimore | Baltimore | Maryland | 21202 | Recruiting |
| Capital Digestive Care - Chevy Chase | Chevy Chase | Maryland | 20815 | Recruiting |
| Lucida Clinical Trials | New Bedford | Massachusetts | 02740 | Recruiting |
| Clinical Research Institute of Michigan, LLC | Clinton Township | Michigan | 48038 | Not yet recruiting |
| Great Lakes Research Institute | Southfield | Michigan | 48075 | Recruiting |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | Recruiting |
| MNGI Digestive Health | Minneapolis | Minnesota | 55413 | Not yet recruiting |
| GI Associates - GIA and Endoscopy Center - Flowood | Flowood | Mississippi | 39232 | Recruiting |
| AMR Clinical | Kansas City | Missouri | 64114 | Not yet recruiting |
| Jubilee Clinical Research NV. LLC | Las Vegas | Nevada | 89106 | Recruiting |
| Excel Clinical Research, LLC | Las Vegas | Nevada | 89109 | Recruiting |
| Advanced Research Institute - Reno | Reno | Nevada | 89511 | Not yet recruiting |
| Tandem Clinical Research - Freehold | Freehold | New Jersey | 07728 | Recruiting |
| Atlantic Health System Morristown Medical Center | Morristown | New Jersey | 07960 | Not yet recruiting |
| Clinical Research of Philadelphia | Pennington | New Jersey | 08534 | Recruiting |
| The Cognitive and Research Center of New Jersey - Ridgewood | Ridgewood | New Jersey | 07450 | Recruiting |
| IMA Clinical Research Warren | Warren Township | New Jersey | 07059 | Recruiting |
| Southwest Gastroenterology Associates | Albuquerque | New Mexico | 87109 | Recruiting |
| Research Foundation of SUNY - University of Buffalo | Buffalo | New York | 14203 | Not yet recruiting |
| NYU Langone Health | New York | New York | 10016 | Not yet recruiting |
| IMA Clinical Research Manhattan | New York | New York | 10036 | Recruiting |
| New York Gastroenterology Associates | New York | New York | 10075 | Recruiting |
| Care Access - Yonkers | Yonkers | New York | 10701 | Recruiting |
| Duke University - Main Hospital and Clinics | Durham | North Carolina | 27710 | Not yet recruiting |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | Recruiting |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | Recruiting |
| Akron Gastro Research | Akron | Ohio | 44320 | Recruiting |
| Dayton Gastroenterology - Beavercreek | Beavercreek | Ohio | 45440 | Not yet recruiting |
| CRIOH | Westlake | Ohio | 44145 | Recruiting |
| US Digestive Health - Flourtown | Flourtown | Pennsylvania | 19031 | Recruiting |
| Penn Medicine: University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | Not yet recruiting |
| US Digestive Health - Wyomissing | Wyomissing | Pennsylvania | 19610 | Recruiting |
| University Gastroenterology | Providence | Rhode Island | 02905 | Recruiting |
| Columbia Digestive Health Research | Columbia | South Carolina | 29204 | Recruiting |
| Galen Medical Group - Galen Hepatology | Chattanooga | Tennessee | 37421 | Recruiting |
| Gastro One (Walnut Run Road) | Cordova | Tennessee | 38018 | Recruiting |
| American Research Corporation at Texas Liver Institute | Austin | Texas | 78215 | Recruiting |
| IMA Clinical Research Austin | Austin | Texas | 78745 | Recruiting |
| American Research Corporation | Austin | Texas | 78757 | Recruiting |
| Pinnacle Clinical Research | Austin | Texas | 78757 | Recruiting |
| Bellaire Clinical Research | Bellaire | Texas | 77401 | Recruiting |
| South Texas Research Institute - Brownsville | Brownsville | Texas | 78520 | Recruiting |
| Headlands Horizons, LLC dba Headlands Research-Brownsville | Brownsville | Texas | 78526 | Recruiting |
| Epic Medical Research - DeSoto | DeSoto | Texas | 75115 | Recruiting |
| Soma Clinical Trials | Denison | Texas | 75020 | Recruiting |
| South Texas Research Institute | Edinburg | Texas | 78539 | Recruiting |
| Dallas Research Institute | Farmers Branch | Texas | 75234 | Recruiting |
| Care United Research, LLC | Forney | Texas | 75126 | Recruiting |
| GI Alliance - Fort Worth | Fort Worth | Texas | 76104 | Not yet recruiting |
| HRI- Medical Center | Houston | Texas | 77004 | Recruiting |
| Care Access - Houston | Houston | Texas | 77054 | Recruiting |
| Houston Research Institute | Houston | Texas | 77079 | Recruiting |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | Recruiting |
| Research Physicians Network, LLC | Houston | Texas | 77089 | Recruiting |
| Biopharma Informatic, LLC | McAllen | Texas | 78503 | Recruiting |
| DHR Health Institute for Research and Development (Administrative Office & Laboratory) | McAllen | Texas | 78504 | Not yet recruiting |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | Recruiting |
| HRI Pasadena | Pasadena | Texas | 77505 | Recruiting |
| Clinical Trials of Texas, LLC dba Flourish Research | San Antonio | Texas | 78229 | Recruiting |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | Recruiting |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | Recruiting |
| GI Alliance - Southlake | Southlake | Texas | 76092 | Recruiting |
| Houston Research Institute (HRI) - Sugar Land | Sugar Land | Texas | 77479 | Recruiting |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | Recruiting |
| Medrasa Clinical Research | Wylie | Texas | 75098 | Recruiting |
| Care Access - Ogden | Ogden | Utah | 84403 | Recruiting |
| Advanced Research Institute - Sandy | Sandy City | Utah | 84070 | Recruiting |
| Eximia Research - Norfolk | Norfolk | Virginia | 23502 | Recruiting |
| Richmond Veterans Affairs Medical Center (Richmond VA Medical Center) | Richmond | Virginia | 23249 | Recruiting |
| Gastroenterology Consultants of Southwest Virginia | Roanoke | Virginia | 24014 | Recruiting |
| Washington Gastroenterology - Bellevue | Bellevue | Washington | 98004 | Recruiting |
| UW Medicine Diabetes Institute | Seattle | Washington | 98109 | Not yet recruiting |
| Washington Gastroenterology - Tacoma | Tacoma | Washington | 98405 | Not yet recruiting |
| CAMC Health Education and Research Institute Inc | Charleston | West Virginia | 25304 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 420 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07165028, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 16, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07165028 live on ClinicalTrials.gov.