Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

ClinicalTrials.gov ID: NCT07166406

Public ClinicalTrials.gov record NCT07166406. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search
ClinicalTrials.gov public records Last synced Sep 2, 2026, 1:54 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Randomized Trial of IO-Based Systemic Treatment +/- Liver SBRT in Hepatocellular Cancer With Macrovascular Invasion (HELIO-RT)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares the effect of immunotherapy (IO) with stereotactic body radiation therapy (SBRT) to IO alone in treating patients with liver cancer (hepatocellular cancer) that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). The usual approach is treatment with IO-based drug combinations, such as atezolizumab and bevacizumab, durvalumab and tremelimumab, or ipilimumab and nivolumab. IO with monoclonal antibodies, such as durvalumab, tremelimumab, atezolizumab, nivolumab and ipilimumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor cells. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Giving IO with SBRT may be more effective than IO alone in helping patients with advanced hepatocellular cancer live longer.

Study identification

NCT ID
NCT07166406
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
NRG Oncology
Other
Enrollment
226 participants

Conditions and interventions

Interventions

Biological · Procedure · Other + 1 more

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 25, 2026
Primary completion
Mar 9, 2029
Completion
Mar 9, 2034
Last update posted
Aug 16, 2026

2026 – 2034

United States locations

U.S. sites
138
U.S. states
23
U.S. cities
111
Facility City State ZIP Site status
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 Recruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California 95682 Recruiting
Palo Alto Medical Foundation-Fremont Fremont California 94538 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
Palo Alto Medical Foundation-Camino Division Mountain View California 94040 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
Palo Alto Medical Foundation Health Care Palo Alto California 94301 Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661 Recruiting
Sutter Roseville Medical Center Roseville California 95661 Recruiting
Sutter Medical Center Sacramento Sacramento California 95816 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
California Pacific Medical Center-Pacific Campus San Francisco California 94115 Recruiting
Sutter Pacific Medical Foundation Santa Rosa California 95403 Recruiting
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086 Recruiting
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907 Recruiting
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 Recruiting
Memorial Hospital North Colorado Springs Colorado 80920 Recruiting
Poudre Valley Hospital Fort Collins Colorado 80524 Recruiting
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 Recruiting
Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado 81501 Recruiting
UCHealth Greeley Hospital Greeley Colorado 80631 Recruiting
Medical Center of the Rockies Loveland Colorado 80538 Recruiting
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418 Recruiting
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824 Recruiting
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033 Recruiting
Smilow Cancer Hospital Care Center at Greenwich Greenwich Connecticut 06830 Recruiting
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437 Recruiting
Smilow Cancer Hospital-Hamden Care Center Hamden Connecticut 06518 Recruiting
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 Recruiting
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510 Recruiting
Yale University New Haven Connecticut 06520 Recruiting
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473 Recruiting
Smilow Cancer Hospital Care Center at Long Ridge Stamford Connecticut 06902 Recruiting
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790 Recruiting
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 Recruiting
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708 Recruiting
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 Recruiting
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801 Recruiting
Grady Health System Atlanta Georgia 30303 Recruiting
Emory Proton Therapy Center Atlanta Georgia 30308 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Saint Joseph's Hospital Atlanta Georgia 30342 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 Recruiting
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 Recruiting
Memorial Hospital East Shiloh Illinois 62269 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
UChicago Medicine Northwest Indiana Crown Point Indiana 46307 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
Mercy Cancer Center-West Lakes Clive Iowa 50325 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Greater Regional Medical Center Creston Iowa 50801 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
Mercy Medical Center-West Lakes West Des Moines Iowa 50266 Recruiting
The Iowa Clinic PC West Des Moines Iowa 50266 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Recruiting
Massachusetts General Hospital Cancer Center Boston Massachusetts 02114 Recruiting
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183 Recruiting
Henry Ford Medical Center-Fairlane Dearborn Michigan 48126 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Allegiance Health Jackson Michigan 49201 Recruiting
Henry Ford Medical Center-Columbus Novi Michigan 48377 Recruiting
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 Recruiting
Henry Ford Wyandotte Hospital Wyandotte Michigan 48192 Recruiting
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 Recruiting
Essentia Health - Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Essentia Health Saint Mary's Medical Center Duluth Minnesota 55805 Recruiting
Miller-Dwan Hospital Duluth Minnesota 55805 Recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Recruiting
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 Recruiting
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 Recruiting
Montefiore Medical Center - Moses Campus The Bronx New York 10467 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Duke Cancer Center Raleigh Raleigh North Carolina 27609 Recruiting
UH Seidman Cancer Center at UH Avon Health Center Avon Ohio 44011 Recruiting
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 Recruiting
Clackamas Radiation Oncology Center Clackamas Oregon 97015 Recruiting
Providence Newberg Medical Center Newberg Oregon 97132 Recruiting
Providence Willamette Falls Medical Center Oregon City Oregon 97045 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 Recruiting
Geisinger Medical Center Danville Pennsylvania 17822 Recruiting
Geisinger Cancer Center Dickson City Dickson City Pennsylvania 18519 Recruiting
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 Recruiting
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 Recruiting
Inova Alexandria Hospital Alexandria Virginia 22304 Recruiting
Inova Schar Cancer Institute Fairfax Virginia 22031 Recruiting
Inova Fair Oaks Hospital Fairfax Virginia 22033 Recruiting
Inova Fairfax Hospital Falls Church Virginia 22042 Recruiting
Inova Loudoun Hospital Leesburg Virginia 20176 Recruiting
Duluth Clinic Ashland Ashland Wisconsin 54806 Recruiting
Northwest Wisconsin Cancer Center Ashland Wisconsin 54806 Recruiting
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 Recruiting
Essentia Health-Hayward Clinic Hayward Wisconsin 54843 Recruiting
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 Recruiting
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Recruiting
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151 Recruiting
Drexel Town Square Health Center Oak Creek Wisconsin 53154 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Recruiting
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 Recruiting
Essentia Health-Spooner Clinic Spooner Wisconsin 54801 Recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 Recruiting
Essentia Health Saint Mary's Hospital - Superior Superior Wisconsin 54880 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095 Recruiting
Marshfield Medical Center - Weston Weston Wisconsin 54476 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07166406, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 16, 2026 · Synced Sep 2, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07166406 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →