ClinicalTrials.gov record
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial
ClinicalTrials.gov ID: NCT07166406
Public ClinicalTrials.gov record NCT07166406. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:06 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Randomized Trial of IO-Based Systemic Treatment +/- Liver SBRT in Hepatocellular Cancer With Macrovascular Invasion (HELIO-RT)
Study identification
- NCT ID
- NCT07166406
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- NRG Oncology
- Other
- Enrollment
- 226 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab Biological
- Bevacizumab Biological
- Biospecimen Collection Procedure
- Computed Tomography Procedure
- Durvalumab Biological
- Ipilimumab Biological
- Magnetic Resonance Imaging Procedure
- Nivolumab Biological
- Positron Emission Tomography Procedure
- Questionnaire Administration Other
- Stereotactic Body Radiation Therapy Radiation
- Tremelimumab Biological
Biological · Procedure · Other + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 25, 2026
- Primary completion
- Mar 9, 2029
- Completion
- Mar 9, 2029
- Last update posted
- May 3, 2026
2026 – 2029
United States locations
- U.S. sites
- 107
- U.S. states
- 18
- U.S. cities
- 86
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | Recruiting |
| Palo Alto Medical Foundation-Fremont | Fremont | California | 94538 | Recruiting |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | Recruiting |
| Palo Alto Medical Foundation-Camino Division | Mountain View | California | 94040 | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | Recruiting |
| Palo Alto Medical Foundation Health Care | Palo Alto | California | 94301 | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | Recruiting |
| Sutter Roseville Medical Center | Roseville | California | 95661 | Recruiting |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | Recruiting |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | Recruiting |
| Sutter Pacific Medical Foundation | Santa Rosa | California | 95403 | Recruiting |
| Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | 94086 | Recruiting |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | Recruiting |
| Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado | 80528 | Recruiting |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81501 | Recruiting |
| UCHealth Greeley Hospital | Greeley | Colorado | 80631 | Recruiting |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | Recruiting |
| Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | 06418 | Recruiting |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | 06824 | Recruiting |
| Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Connecticut | 06033 | Recruiting |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Connecticut | 06830 | Recruiting |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut | 06437 | Recruiting |
| Smilow Cancer Hospital-Hamden Care Center | Hamden | Connecticut | 06518 | Recruiting |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | Recruiting |
| Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | 06510 | Recruiting |
| Yale University | New Haven | Connecticut | 06520 | Recruiting |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | 06473 | Recruiting |
| Smilow Cancer Hospital Care Center at Long Ridge | Stamford | Connecticut | 06902 | Recruiting |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | 06790 | Recruiting |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | 06611 | Recruiting |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | 06708 | Recruiting |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | 06385 | Recruiting |
| Grady Health System | Atlanta | Georgia | 30303 | Recruiting |
| Emory Proton Therapy Center | Atlanta | Georgia | 30308 | Recruiting |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | Recruiting |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | Recruiting |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | Recruiting |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | Recruiting |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | Recruiting |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| Memorial Hospital East | Shiloh | Illinois | 62269 | Recruiting |
| UChicago Medicine Northwest Indiana | Crown Point | Indiana | 46307 | Recruiting |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | Recruiting |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | Recruiting |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | Recruiting |
| Greater Regional Medical Center | Creston | Iowa | 50801 | Recruiting |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | Recruiting |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | Recruiting |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | Recruiting |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | Recruiting |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | Recruiting |
| Mercy Medical Center-West Lakes | West Des Moines | Iowa | 50266 | Recruiting |
| The Iowa Clinic PC | West Des Moines | Iowa | 50266 | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | Recruiting |
| Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | 48183 | Recruiting |
| Henry Ford Medical Center-Fairlane | Dearborn | Michigan | 48126 | Recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Recruiting |
| Allegiance Health | Jackson | Michigan | 49201 | Recruiting |
| Henry Ford Medical Center-Columbus | Novi | Michigan | 48377 | Recruiting |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | 48322 | Recruiting |
| Henry Ford Wyandotte Hospital | Wyandotte | Michigan | 48192 | Recruiting |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | Recruiting |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | Recruiting |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | Recruiting |
| Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | 55805 | Recruiting |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | Recruiting |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | Recruiting |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | Recruiting |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | Recruiting |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | Recruiting |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | Recruiting |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | Recruiting |
| Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | Recruiting |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | Recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| Clackamas Radiation Oncology Center | Clackamas | Oregon | 97015 | Recruiting |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | Recruiting |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | Recruiting |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Recruiting |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | Recruiting |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | Recruiting |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | Recruiting |
| Inova Alexandria Hospital | Alexandria | Virginia | 22304 | Recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
| Inova Fair Oaks Hospital | Fairfax | Virginia | 22033 | Recruiting |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | Recruiting |
| Inova Loudoun Hospital | Leesburg | Virginia | 20176 | Recruiting |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | Recruiting |
| Northwest Wisconsin Cancer Center | Ashland | Wisconsin | 54806 | Recruiting |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | Recruiting |
| Essentia Health-Hayward Clinic | Hayward | Wisconsin | 54843 | Recruiting |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | Recruiting |
| ProHealth D N Greenwald Center | Mukwonago | Wisconsin | 53149 | Recruiting |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | Recruiting |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | Recruiting |
| Essentia Health-Spooner Clinic | Spooner | Wisconsin | 54801 | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | Recruiting |
| Essentia Health Saint Mary's Hospital - Superior | Superior | Wisconsin | 54880 | Recruiting |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | Recruiting |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07166406, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07166406 live on ClinicalTrials.gov.