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Recruiting Phase 3 Interventional

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

ClinicalTrials.gov ID: NCT07188558

Public ClinicalTrials.gov record NCT07188558. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 6:04 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized Controlled Trial of Rondecabtagene Autoleucel , an Autologous, Dual-targeting CD19/CD20 CAR T-Cell Product Candidate, Vs. Investigator's Choice of CD19 CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-Cell Lymphoma in the Second-line Setting

Study identification

NCT ID
NCT07188558
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Lyell Immunopharma, Inc.
Industry
Enrollment
400 participants

Conditions and interventions

Interventions

  • rondecabtagene autoleucel Biological
  • axicabtagene ciloleucel Biological
  • lisocabtagene maraleucel Biological

Biological

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jan 11, 2026
Primary completion
Nov 30, 2029
Completion
Dec 31, 2031
Last update posted
Jun 7, 2026

2026 – 2032

United States locations

U.S. sites
38
U.S. states
23
U.S. cities
34
Facility City State ZIP Site status
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Not yet recruiting
Honor Health Scottsdale Arizona 85258 Recruiting
Mayo Clinic Arizona Scottsdale Arizona 85259 Recruiting
University of Arkansas Little Rock Arkansas 72205 Not yet recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
University of California, Los Angeles (UCLA) Los Angeles California 90095 Not yet recruiting
University of California, Irvine Orange California 92868 Not yet recruiting
University of Colorado Aurora Colorado 80045 Recruiting
Colorado Blood Cancer Institute Denver Colorado 80218 Recruiting
MedStar Georgetown University Hospital Washington D.C. District of Columbia 20007 Not yet recruiting
Mayo Clinic Florida Jacksonville Florida 32224 Recruiting
AdventHealth Orlando Florida 32804 Not yet recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Northside Hospital Atlanta Georgia 30342 Active, not recruiting
Northwestern Chicago Illinois 60611 Not yet recruiting
University of Chicago Chicago Illinois 60637 Not yet recruiting
University of Iowa Iowa City Iowa 52242 Not yet recruiting
University of Kansas Cancer Center Westwood Kansas 66205 Not yet recruiting
University of Kentucky Lexington Kentucky 40536 Not yet recruiting
University of Louisville Health Louisville Kentucky 40202 Not yet recruiting
Corewell Health Grand Rapids Michigan 49503 Not yet recruiting
Mayo Clinic Rochester Rochester Minnesota 55905 Recruiting
University of Nebraska Medical Center (UNMC) Omaha Nebraska 68105 Recruiting
Hackensack Hackensack New Jersey 07601 Not yet recruiting
Roswell Park Comprehensive Cancer Center Buffalo New York 14263 Not yet recruiting
Duke Cancer Institute Durham North Carolina 27705 Recruiting
Atrium Health Wake Forest Baptist Comprehensive Cancer Center Winston-Salem North Carolina 27157 Not yet recruiting
Oncology Hematology Care Clinical Trials Cincinnati Ohio 45242 Recruiting
University of Cincinnati Cincinnati Ohio 45267 Not yet recruiting
Cleveland Clinical Taussig Cancer Center Cleveland Ohio 44195 Not yet recruiting
Allegheny Health Network Pittsburgh Pennsylvania 15212 Not yet recruiting
SCRI Oncology Partners Nashville Tennessee 37203 Recruiting
St. David's South Austin Medical Center Austin Texas 78704 Recruiting
University of Texas Southwestern Medical Center Fort Worth Texas 76104 Not yet recruiting
MD Anderson Cancer Center Houston Texas 77030 Not yet recruiting
Texas Transplant Institute San Antonio Texas 78229 Recruiting
Intermountain Healthcare Salt Lake City Utah 84143 Recruiting
Virginia Oncology Associates Norfolk Virginia 23502 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07188558, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jun 7, 2026 · Synced Jul 21, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07188558 live on ClinicalTrials.gov.

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