Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

ClinicalTrials.gov ID: NCT07195734

Public ClinicalTrials.gov record NCT07195734. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 4:50 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Randomized Trial of Neoadjuvant Chemotherapy or Chemo-Immunotherapy in Patients With Recurrent/Persistent PD-L1 Enriched Squamous Cell Carcinoma of the Head and Neck Undergoing Salvage Surgery (NEOPOLIS)

Study identification

NCT ID: NCT07195734
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 180 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Carboplatin Drug
Cemiplimab Biological
Cisplatin Drug
Computed Tomography Procedure
Paclitaxel Drug
Positron Emission Tomography Procedure
Radiation Therapy Radiation
Salvage Surgery Procedure

Procedure · Drug · Biological + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 23, 2026
Primary completion: Jan 31, 2033
Completion: Jan 31, 2033
Last update posted: Apr 30, 2026

2026 – 2033

United States locations

U.S. sites: 40
U.S. states: 12
U.S. cities: 30

Facility	City	State	ZIP	Site status
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Sutter Medical Center Sacramento	Sacramento	California	95816	Recruiting
Emory Proton Therapy Center	Atlanta	Georgia	30308	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Rush MD Anderson Cancer Center	Chicago	Illinois	60612	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Methodist Jennie Edmundson Hospital	Council Bluffs	Iowa	51503	Suspended
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Recruiting
LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	70805	Recruiting
Our Lady of the Lake Physician Group	Baton Rouge	Louisiana	70808	Recruiting
University of Michigan Rogel Cancer Center	Ann Arbor	Michigan	48109	Recruiting
University of Michigan - Brighton Center for Specialty Care	Brighton	Michigan	48116	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
University of Kansas Cancer Center - Briarcliff	Kansas City	Missouri	64116	Recruiting
University of Kansas Cancer Center - North	Kansas City	Missouri	64154	Recruiting
University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	64064	Recruiting
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC	Omaha	Nebraska	68114	Recruiting
Nebraska Methodist Hospital	Omaha	Nebraska	68114	Recruiting
Clackamas Radiation Oncology Center	Clackamas	Oregon	97015	Recruiting
Providence Newberg Medical Center	Newberg	Oregon	97132	Recruiting
Providence Willamette Falls Medical Center	Oregon City	Oregon	97045	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center	Madison	Wisconsin	53718	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting
Froedtert Menomonee Falls Hospital	Menomonee Falls	Wisconsin	53051	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Froedtert and MCW Moorland Reserve Health Center	New Berlin	Wisconsin	53151	Recruiting
Drexel Town Square Health Center	Oak Creek	Wisconsin	53154	Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center	West Bend	Wisconsin	53095	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07195734, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced May 5, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07195734 live on ClinicalTrials.gov.

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