Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

ClinicalTrials.gov ID: NCT07198074

Public ClinicalTrials.gov record NCT07198074. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 9, 2026, 11:17 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase III Trial of Carboplatin, Paclitaxel, Pembrolizumab Versus Carboplatin, Paclitaxel, Bevacizumab Versus Carboplatin, Paclitaxel, Pembrolizumab, Bevacizumab in the Treatment of pMMR, TP53 Mutated Advanced or Recurrent Endometrial Cancer

Study identification

NCT ID: NCT07198074
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 255 participants

Conditions and interventions

Conditions

Interventions

Bevacizumab Biological
Biospecimen Collection Procedure
Carboplatin Drug
Computed Tomography Procedure
Magnetic Resonance Imaging Procedure
Paclitaxel Drug
Pembrolizumab Biological

Biological · Procedure · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: Female
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 26, 2026
Primary completion: Jun 30, 2028
Completion: Jun 30, 2028
Last update posted: May 7, 2026

2026 – 2028

United States locations

U.S. sites: 167
U.S. states: 33
U.S. cities: 136

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Recruiting
Cancer Center at Saint Joseph's	Phoenix	Arizona	85004	Recruiting
Mercy Cancer Center - Carmichael	Carmichael	California	95608	Recruiting
Mercy San Juan Medical Center	Carmichael	California	95608	Recruiting
Mercy Cancer Center - Elk Grove	Elk Grove	California	95758	Recruiting
Eisenhower Medical Center	Rancho Mirage	California	92270	Recruiting
Mercy Cancer Center - Rocklin	Rocklin	California	95765	Recruiting
Mercy Cancer Center - Sacramento	Sacramento	California	95816	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
Woodland Memorial Hospital	Woodland	California	95695	Recruiting
Helen F Graham Cancer Center	Newark	Delaware	19713	Recruiting
Medical Oncology Hematology Consultants PA	Newark	Delaware	19713	Recruiting
Augusta University Medical Center	Augusta	Georgia	30912	Recruiting
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
Rush MD Anderson Cancer Center	Chicago	Illinois	60612	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Northwestern Medicine Oak Brook	Oak Brook	Illinois	60523	Recruiting
Northwestern Medicine Orland Park	Orland Park	Illinois	60462	Recruiting
OSF Saint Francis Medical Center	Peoria	Illinois	61637	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Goshen Center for Cancer Care	Goshen	Indiana	46526	Recruiting
Memorial Hospital of South Bend	South Bend	Indiana	46601	Recruiting
Mercy Hospital	Cedar Rapids	Iowa	52403	Recruiting
Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	52403	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
West Jefferson Medical Center	Marrero	Louisiana	70072	Recruiting
East Jefferson General Hospital	Metairie	Louisiana	70006	Recruiting
LSU Healthcare Network / Metairie Multi-Specialty Clinic	Metairie	Louisiana	70006	Recruiting
University Medical Center New Orleans	New Orleans	Louisiana	70112	Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	21287	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
OSF Saint Francis Hospital and Medical Group	Escanaba	Michigan	49829	Recruiting
Genesys Hurley Cancer Institute	Flint	Michigan	48503	Recruiting
Hurley Medical Center	Flint	Michigan	48503	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	56401	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Essentia Health - Deer River Clinic	Deer River	Minnesota	56636	Recruiting
Essentia Health Cancer Center	Duluth	Minnesota	55805	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Essentia Health Hibbing Clinic	Hibbing	Minnesota	55746	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
United Hospital	Saint Paul	Minnesota	55102	Recruiting
Essentia Health Sandstone	Sandstone	Minnesota	55072	Recruiting
Essentia Health Virginia Clinic	Virginia	Minnesota	55792	Recruiting
Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	55125	Recruiting
Mercy Hospital Springfield	Springfield	Missouri	65804	Recruiting
CoxHealth South Hospital	Springfield	Missouri	65807	Recruiting
Community Hospital of Anaconda	Anaconda	Montana	59711	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Health Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Nebraska Medicine-Bellevue	Bellevue	Nebraska	68123	Recruiting
Fred and Pamela Buffett Cancer Center - Kearney	Kearney	Nebraska	68845	Recruiting
Nebraska Methodist Hospital	Omaha	Nebraska	68114	Recruiting
Nebraska Medicine-Village Pointe	Omaha	Nebraska	68118	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
Rutgers New Jersey Medical School	Newark	New Jersey	07101	Recruiting
The Valley Hospital - Luckow Pavilion	Paramus	New Jersey	07652	Recruiting
Valley Health System Ridgewood Campus	Ridgewood	New Jersey	07450	Recruiting
Sidney Kimmel Cancer Center Washington Township	Sewell	New Jersey	08080	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Northwell Health Imbert Cancer Center	Bay Shore	New York	11706	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Northwell Health Physician Partners at Flushing	Flushing	New York	11354	Recruiting
Northwell Health Cancer Institute at Huntington	Greenlawn	New York	11740	Recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
Northwell Health/Center for Advanced Medicine	Lake Success	New York	11042	Recruiting
Manhattan Eye Ear and Throat Hospital	New York	New York	10065	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Lenox Hill Hospital	New York	New York	10075	Recruiting
Queens Cancer Center	Rego Park	New York	11374	Recruiting
Phelps Memorial Hospital Center	Sleepy Hollow	New York	10591	Recruiting
Staten Island University Hospital	Staten Island	New York	10305	Recruiting
Stony Brook University Medical Center	Stony Brook	New York	11794	Recruiting
Montefiore Medical Center-Einstein Campus	The Bronx	New York	10461	Recruiting
Montefiore Medical Center-Weiler Hospital	The Bronx	New York	10461	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	28328	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	27534	Recruiting
Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	28546	Recruiting
Duke Women's Cancer Care Raleigh	Raleigh	North Carolina	27607	Recruiting
Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	58103	Recruiting
OhioHealth O'Bleness Hospital	Athens	Ohio	45701	Recruiting
UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	44122	Recruiting
Geauga Hospital	Chardon	Ohio	44024	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	43214	Recruiting
Riverside Methodist Hospital	Columbus	Ohio	43214	Recruiting
Grant Medical Center	Columbus	Ohio	43215	Recruiting
Doctors Hospital	Columbus	Ohio	43228	Recruiting
Delaware Health Center-Grady Cancer Center	Delaware	Ohio	43015	Recruiting
Grady Memorial Hospital	Delaware	Ohio	43015	Recruiting
Columbus Oncology and Hematology Associates	Dublin	Ohio	43016	Recruiting
Dublin Methodist Hospital	Dublin	Ohio	43016	Recruiting
OhioHealth Mansfield Hospital	Mansfield	Ohio	44903	Recruiting
OhioHealth Marion General Hospital	Marion	Ohio	43302	Recruiting
UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	44060	Recruiting
University Hospitals Parma Medical Center	Parma	Ohio	44129	Recruiting
OhioHealth Pickerington Methodist Hospital	Pickerington	Ohio	43147	Recruiting
ProMedica Flower Hospital	Sylvania	Ohio	43560	Recruiting
OhioHealth Westerville Medical Campus/Westerville Cancer Center	Westerville	Ohio	43082	Recruiting
UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	44145	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	97210	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Legacy Meridian Park Hospital	Tualatin	Oregon	97062	Recruiting
UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	16505	Recruiting
UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	15601	Recruiting
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion	Mechanicsburg	Pennsylvania	17050	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	19114	Recruiting
UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	15237	Recruiting
UPMC Cancer Center-Washington	Washington	Pennsylvania	15301	Recruiting
Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	19090	Recruiting
Women and Infants Hospital	Providence	Rhode Island	02905	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
University of Utah Sugarhouse Health Center	Salt Lake City	Utah	84106	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
South Jordan Health Center	South Jordan	Utah	84009	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Swedish Cancer Institute-Edmonds	Edmonds	Washington	98026	Recruiting
Swedish Cancer Institute-Issaquah	Issaquah	Washington	98029	Recruiting
Swedish Medical Center-First Hill	Seattle	Washington	98122	Recruiting
Legacy Salmon Creek Hospital	Vancouver	Washington	98686	Recruiting
United Hospital Center	Bridgeport	West Virginia	26330	Recruiting
West Virginia University Charleston Division	Charleston	West Virginia	25304	Recruiting
WVUH-Berkely Medical Center	Martinsburg	West Virginia	25401	Recruiting
West Virginia University Healthcare	Morgantown	West Virginia	26506	Recruiting
Camden Clark Medical Center	Parkersburg	West Virginia	26101	Recruiting
Duluth Clinic Ashland	Ashland	Wisconsin	54806	Recruiting
Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	54301	Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	54303	Recruiting
Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	54154	Recruiting
Saint Vincent Hospital Cancer Center at Sheboygan	Sheboygan	Wisconsin	53081	Recruiting
Sheboygan Physicians Group	Sheboygan	Wisconsin	53081	Recruiting
Essentia Health-Spooner Clinic	Spooner	Wisconsin	54801	Recruiting
Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	54235-1495	Recruiting
Essentia Health Saint Mary's Hospital - Superior	Superior	Wisconsin	54880	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07198074, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 7, 2026 · Synced May 9, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07198074 live on ClinicalTrials.gov.

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