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Recruiting Phase 3 Interventional

Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

ClinicalTrials.gov ID: NCT07215910

Public ClinicalTrials.gov record NCT07215910. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 11:35 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Trial of Radiotherapy Followed by Adjuvant Temozolomide in Combination With the IDH Inhibitor Vorasidenib vs Placebo in IDH-Mutated Newly-Diagnosed Grade 3 Astrocytomas

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares the effect of vorasidenib to placebo in combination with usual treatment, temozolomide, in treating patients with newly diagnosed grade 3 astrocytoma after radiation. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid and may kill tumor cells and slow down or stop tumor growth. Vorasidenib citrate blocks the proteins made by the mutated IDH1 and IDH2 genes, which may help keep tumor cells from growing. It is a type of enzyme inhibitor and a type of targeted therapy. Adding vorasidenib to the usual treatment, temozolomide, may be more effective than temozolomide alone in treating patients with newly diagnosed grade 3 astrocytoma after radiation therapy.

Study identification

NCT ID
NCT07215910
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
408 participants

Conditions and interventions

Eligibility (public fields only)

Age range
12 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 23, 2026
Primary completion
May 30, 2033
Completion
Dec 31, 2039
Last update posted
Sep 1, 2026

2026 – 2040

United States locations

U.S. sites
121
U.S. states
24
U.S. cities
99
Facility City State ZIP Site status
AIS Cancer Center at San Joaquin Community Hospital Bakersfield California 93301 Recruiting
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
Yale University New Haven Connecticut 06520 Recruiting
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 Recruiting
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs Coral Springs Florida 33065 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood Florida 33021 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia North Miami Florida 33181 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
OSF Saint Joseph Medical Center Bloomington Illinois 61701 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026 Recruiting
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois 61615 Recruiting
OSF Saint Francis Medical Center Peoria Illinois 61637 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
Midwestern Regional Medical Center Zion Illinois 60099 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Broadlawns Medical Center Des Moines Iowa 50314 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
UI Healthcare Mission Cancer and Blood - Pella Pella Iowa 50219 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Recruiting
University of Kansas Hospital-Indian Creek Campus Overland Park Kansas 66211 Recruiting
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 Recruiting
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 Recruiting
UofL Health Medical Center Northeast Louisville Kentucky 40245 Recruiting
West Jefferson Medical Center Marrero Louisiana 70072 Recruiting
East Jefferson General Hospital Metairie Louisiana 70006 Recruiting
University Medical Center New Orleans New Orleans Louisiana 70112 Recruiting
Children's Hospital New Orleans New Orleans Louisiana 70118 Recruiting
MaineHealth Coastal Cancer Treatment Center Bath Maine 04530 Recruiting
MaineHealth Maine Medical Center - Portland Portland Maine 04102 Recruiting
MaineHealth Cancer Care Center of York County Sanford Maine 04073 Recruiting
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 Recruiting
University of Michigan - Brighton Center for Specialty Care Brighton Michigan 48116 Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 Recruiting
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids Michigan 49503 Recruiting
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 Suspended
University of Michigan Health - West Wyoming Michigan 49519 Recruiting
Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Fairview Southdale Hospital Edina Minnesota 55435 Recruiting
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
University of Kansas Cancer Center - Briarcliff Kansas City Missouri 64116 Recruiting
University of Kansas Cancer Center - North Kansas City Missouri 64154 Recruiting
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 Recruiting
Mercy Hospital Springfield Springfield Missouri 65804 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Hackensack University Medical Center Hackensack New Jersey 07601 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Northwell Health Imbert Cancer Center Bay Shore New York 11706 Recruiting
NYU Langone Hospital - Brooklyn Brooklyn New York 11220 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Memorial Sloan Kettering Westchester Harrison New York 10604 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Northern Westchester Hospital Mount Kisco New York 10549 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 Recruiting
UPMC Hillman Cancer Center Erie Erie Pennsylvania 16505 Recruiting
Forbes Hospital Monroeville Pennsylvania 15146 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
Allegheny General Hospital Pittsburgh Pennsylvania 15212 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
UPMC-Shadyside Hospital Pittsburgh Pennsylvania 15232 Recruiting
Wexford Health and Wellness Pavilion Wexford Pennsylvania 15090 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Recruiting
University of Vermont Medical Center Burlington Vermont 05401 Recruiting
University of Vermont and State Agricultural College Burlington Vermont 05405 Recruiting
Swedish Medical Center-First Hill Seattle Washington 98122 Recruiting
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Suspended
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151 Recruiting
Drexel Town Square Health Center Oak Creek Wisconsin 53154 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Suspended
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Suspended
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07215910, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 1, 2026 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07215910 live on ClinicalTrials.gov.

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