A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema
Public ClinicalTrials.gov record NCT07216027. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08049820 IN ADULT PARTICIPANTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn if the study medicine (PF-08049820) is safe and effective for the treatment of atopic dermatitis (AD), also known as eczema, or atopic eczema. People with this condition may have severe itching and rashes on the skin. The study is seeking participants who: 1. Are 18 to 64 years of age; 2. Were confirmed to have AD at least 6 months ago; 3. Do not have a suitable prescribed medicine for AD; 4. Are considered by their doctors to have moderate to severe AD. The study has two stages (Stage 1 and Stage 2). In both stages, eligible participants will take either PF-08049820 or placebo as tablets by mouth daily for 12 weeks. A placebo does not have any medicine in it but looks just like the medicine being studied. Participants will visit the clinic on Day 1, Weeks 1, 2, 4, 6, 8 and 12. They will have a follow-up visit at Week 16. During this time, the participant's health and skin condition will be checked. They will have blood and urine tests. They will also have to answer questions about their health, skin condition, and how much their skin condition affects their lives. The experiences of participants receiving the study medicine will be compared to those receiving placebo. This will help to understand if PF-08049820 is safe and effective.
Study identification
- NCT ID
- NCT07216027
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 165 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 64 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 20, 2025 (Actual)
- Primary completion
- Feb 2, 2028 (Estimated)
- Completion
- Feb 2, 2028 (Estimated)
- Last update posted
- Oct 13, 2026
2025 – 2028
United States locations
- U.S. sites
- 17
- U.S. states
- 6
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | Recruiting |
| Mayo Clinic Specialty Building | Phoenix | Arizona | 85054 | Recruiting |
| Mayo Clinic | Scottsdale | Arizona | 85259 | Recruiting |
| Marvel Clinical Research | Huntington Beach | California | 92647 | Recruiting |
| Metropolis Dermatology - DTLA | Los Angeles | California | 90017 | Not yet recruiting |
| Northridge Clinical Trials | Northridge | California | 91325 | Recruiting |
| Clinical Science Institute | Santa Monica | California | 90403 | Recruiting |
| Gsi Clinical Research | Margate | Florida | 33063 | Recruiting |
| Skin Research of South Florida | Miami | Florida | 33173 | Active, not recruiting |
| Montefiore - Jacobi Dermatology Clinic | The Bronx | New York | 10461 | Recruiting |
| Montefiore - Clinical Research Center | The Bronx | New York | 10467 | Recruiting |
| Montefiore - Greene Medical Arts Pavillion | The Bronx | New York | 10467 | Recruiting |
| Montefiore - The Dermatology Center | The Bronx | New York | 10467 | Recruiting |
| Montefiore Medical Center | The Bronx | New York | 10467 | Recruiting |
| Apex Clinical Research Center, LLC. | Mayfield Heights | Ohio | 44124 | Not yet recruiting |
| Paddington Testing Co, Inc | Philadelphia | Pennsylvania | 19103 | Recruiting |
| UPMC Department of Dermatology | Pittsburgh | Pennsylvania | 15213 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07216027, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07216027 live on ClinicalTrials.gov.