Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

ClinicalTrials.gov ID: NCT07222566

Public ClinicalTrials.gov record NCT07222566. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 7:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

AN INTERVENTIONAL PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS PEMBROLIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER

Study identification

NCT ID: NCT07222566
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Pfizer; Industry
Enrollment: 1,410 participants

Conditions and interventions

Conditions

Interventions

Chemotherapy Regimen 1 Drug
Chemotherapy Regimen 2 Drug
PF-08634404 Biological
Pembrolizumab Biological

Drug · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 5, 2026
Primary completion: Feb 26, 2029
Completion: Aug 25, 2032
Last update posted: Apr 19, 2026

2026 – 2032

United States locations

U.S. sites: 151
U.S. states: 16
U.S. cities: 127

Facility	City	State	ZIP	Site status
Pioneer Research Center	Bullhead City	Arizona	86442	Recruiting
Ironwood Cancer & Research Centers	Chandler	Arizona	85224	Recruiting
Ironwood Cancer & Research Centers	Gilbert	Arizona	85297	Recruiting
Ironwood Cancer & Research Centers	Glendale	Arizona	85306	Recruiting
Ironwood Cancer & Research Centers	Goodyear	Arizona	85395	Recruiting
Ironwood Cancer & Research Centers	Mesa	Arizona	85202	Recruiting
Ironwood Cancer & Research Centers	Mesa	Arizona	85206	Recruiting
Ironwood Cancer & Research Centers	Phoenix	Arizona	85028	Recruiting
Ironwood Cancer & Research Centers	Scottsdale	Arizona	85260	Recruiting
Highlands Oncology Group	Fayetteville	Arkansas	72703	Recruiting
Highlands Oncology Group	Rogers	Arkansas	72758	Recruiting
Highlands Oncology Group	Springdale	Arkansas	72762	Recruiting
Los Angeles Cancer Network - Anaheim	Anaheim	California	92805	Recruiting
Orange Coast Memorial Medical Center	Fountain Valley	California	92703	Not yet recruiting
Los Angeles Cancer Network - Fountain Valley	Fountain Valley	California	92708	Recruiting
Memorial Care Orange Coast Medical Center Attn	Fountain Valley	California	92708	Not yet recruiting
OC Blood and Cancer Care	Fountain Valley	California	92708	Not yet recruiting
Orange Coast Memorial Medical Center	Fountain Valley	California	92708	Not yet recruiting
Memorial Care Saddleback Medical Center Attn	Laguna Hills	California	92653	Not yet recruiting
Memorial Care Long Beach Medical Center	Long Beach	California	90806	Not yet recruiting
Los Angeles Cancer Network - Good Samaritan	Los Angeles	California	90017	Recruiting
Los Angeles Cancer Network - Riverside	Riverside	California	92501	Recruiting
Sansum Clinic	Santa Barbara	California	93105	Recruiting
Sansum Clinic	Solvang	California	93463	Recruiting
Los Angeles Cancer Network - Valley Presbyterian	Van Nuys	California	91405	Recruiting
Florida Cancer Specialists	Bonita Springs	Florida	34135	Recruiting
Florida Cancer Specialists	Bradenton	Florida	34211	Recruiting
Florida Cancer Specialists	Cape Coral	Florida	33909	Recruiting
Florida Cancer Specialists	Clearwater	Florida	33761	Recruiting
BRCR Global- Coral Springs	Coral Springs	Florida	33065	Recruiting
Florida Cancer Specialists	Daytona Beach	Florida	32117	Recruiting
Florida Cancer Specialists	Fleming Island	Florida	32003	Recruiting
Helios Clinical Research	Fort Lauderdale	Florida	33316	Recruiting
Florida Cancer Specialists - South	Fort Myers	Florida	33901	Recruiting
Florida Cancer Specialists	Fort Myers	Florida	33905	Recruiting
Florida Cancer Specialists	Fort Myers	Florida	33908	Recruiting
Florida Cancer Specialists	Gainesville	Florida	32605	Recruiting
Florida Cancer Specialists	Largo	Florida	33770	Recruiting
Florida Cancer Specialists	Lecanto	Florida	34461	Recruiting
Florida Cancer Specialists	N. Venice	Florida	34275	Recruiting
Florida Cancer Specialists	Naples	Florida	34102	Recruiting
Florida Cancer Specialists	Ocala	Florida	34474	Recruiting
Florida Cancer Specialists	Orange City	Florida	32763	Recruiting
Mid Florida Hematology and Oncology Center	Orange City	Florida	32763	Recruiting
Florida Cancer Specialists	Orlando	Florida	32806	Recruiting
Orlando Health Ambulatory Care Center	Orlando	Florida	32806	Not yet recruiting
Orlando Health Cancer Institute	Orlando	Florida	32806	Not yet recruiting
Orlando Health Orlando Regional Medical Center	Orlando	Florida	32806	Not yet recruiting
Cancer Care Centers of Brevard, Inc.	Palm Bay	Florida	32901	Recruiting
Florida Cancer Specialists	Palm Beach Gardens	Florida	33410	Recruiting
Florida Cancer Specialists	Port Charlotte	Florida	33980	Recruiting
Hematology Oncology Associates of the Treasure Coast	Port Saint Lucie	Florida	34952	Recruiting
Florida Cancer Specialists	Sarasota	Florida	34236	Recruiting
Florida Cancer Specialists	Sebring	Florida	33870	Recruiting
Florida Cancer Specialists	St. Petersburg	Florida	33701	Recruiting
Florida Cancer Specialists	St. Petersburg	Florida	33705	Recruiting
Florida Cancer Specialists	Tallahassee	Florida	32308	Recruiting
BRCR Global - Tamarac	Tamarac	Florida	33321	Recruiting
Florida Cancer Specialists	Tampa	Florida	33607	Recruiting
Florida Cancer Specialists	Tavares	Florida	32778	Recruiting
Florida Cancer Specialists	The Villages	Florida	32159	Recruiting
Florida Cancer Specialists	Trinity	Florida	34655	Recruiting
Florida Cancer Specialists	Wellington	Florida	33414	Recruiting
Florida Cancer Specialists - East	West Palm Beach	Florida	33401	Recruiting
Florida Cancer Specialists	Winter Park	Florida	32789	Recruiting
Illinois Cancer Specialists	Arlington Heights	Illinois	60005	Recruiting
Illinois CancerCare - Bloomington	Bloomington	Illinois	61704	Recruiting
Illinois CancerCare - Galesburg	Galesburg	Illinois	61401	Recruiting
Hope and Healing Cancer Services	Hinsdale	Illinois	60521	Recruiting
Hope and Healing Cancer Services	New Lenox	Illinois	60451	Recruiting
Illinois CancerCare-Ottawa-Fox River Cancer Center	Ottawa	Illinois	61350	Recruiting
Illinois CancerCare-Pekin	Pekin	Illinois	61554	Recruiting
Illinois CancerCare, P.C.	Peoria	Illinois	61615	Recruiting
Illinois CancerCare-Peru - Valley Regional Cancer Center	Peru	Illinois	61354	Recruiting
Illinois CancerCare-Washington	Washington	Illinois	61571	Recruiting
Maryland Oncology Hematology, P.A.	Annapolis	Maryland	21401	Recruiting
Maryland Oncology Hematology, P.A.	Bethesda	Maryland	20817	Recruiting
Maryland Oncology Hematology, P.A.	Brandywine	Maryland	20613	Recruiting
Maryland Oncology Hematology - Columbia	Columbia	Maryland	21044	Recruiting
Maryland Oncology Hematology, P.A.	Germantown	Maryland	20876	Recruiting
Maryland Oncology Hematology, P.A.	Largo	Maryland	20774	Recruiting
Maryland Oncology Hematology, P.A.	Rockville	Maryland	20850	Recruiting
Maryland Oncology Hematology, P.A.	Silver Spring	Maryland	20904	Recruiting
Minnesota Oncology Hematology, P.A.	Burnsville	Minnesota	55337	Recruiting
Minnesota Oncology Hematology, P.A.	Chaska	Minnesota	55318	Recruiting
Minnesota Oncology Hematology, P.A.	Coon Rapids	Minnesota	55433	Recruiting
Minnesota Oncology Hematology, P.A.	Edina	Minnesota	55435	Recruiting
Minnesota Oncology Hematology, P.A.	Maple Grove	Minnesota	55369	Recruiting
Minnesota Oncology Hematology, P.A.	Maplewood	Minnesota	55109	Recruiting
Minnesota Oncology Hematology, P.A.	Woodbury	Minnesota	55125	Recruiting
NHO Revive Research Institute, LLC	Lincoln	Nebraska	68506	Not yet recruiting
Cancer Partners of Nebraska - April Sampson Cancer Center	Lincoln	Nebraska	68516	Recruiting
New York Oncology Hematology	Albany	New York	12206	Recruiting
New York Oncology Hematology	Clifton Park	New York	12065	Recruiting
Hematology Oncology Associates of Rockland	Nyack	New York	10960	Recruiting
Carolina Cancer Research Center	Wilson	North Carolina	27893	Not yet recruiting
Oncology Hematology Care Clinical Trials	Cincinnati	Ohio	45211	Recruiting
Oncology Hematology Care Clinical Trials	Cincinnati	Ohio	45242	Recruiting
Oncology Hematology Care Clinical Trials	Cincinnati	Ohio	45245	Recruiting
Oncology Hematology Care Clinical Trials	Fairfield	Ohio	45014	Recruiting
Northwest Cancer Specialists, P.C.	Portland	Oregon	97213	Recruiting
Northwest Cancer Specialists, P.C.	Portland	Oregon	97227	Recruiting
Northwest Cancer Specialists, P.C.	Tigard	Oregon	97223	Recruiting
Tennessee Oncology, PLLC - Chattanooga Downtown	Chattanooga	Tennessee	37403	Recruiting
Tennessee Oncology, PLLC - Chattanooga - Medical Park II	Chattanooga	Tennessee	37404	Recruiting
Tennessee Oncology, PLLC - Franklin	Franklin	Tennessee	37067	Recruiting
Tennessee Oncology, PLLC - Gallatin	Gallatin	Tennessee	37066	Recruiting
Tennessee Cancer Specialists Dowell Springs location	Knoxville	Tennessee	37909	Recruiting
Tennessee Oncology, PLLC - Lebanon	Lebanon	Tennessee	37090	Recruiting
Tennesseee Oncology, PLLC - Mount Juliet	Mount Juliet	Tennessee	37122	Recruiting
Tennessee Oncology, PLLC - Murfreesboro	Murfreesboro	Tennessee	37129	Recruiting
SCRI Oncology Partners	Nashville	Tennessee	37203	Recruiting
Tennessee Oncology, PLLC-Elliston Place Plaza Medical Oncology &Hematology	Nashville	Tennessee	37203	Recruiting
Tennessee Oncology, PLLC - Saint Thomas West	Nashville	Tennessee	37205	Recruiting
Tennessee Oncology, PLLC -Shelbyville	Shelbyville	Tennessee	37160	Recruiting
Texas Oncology - West Texas	Abilene	Texas	79606	Recruiting
Texas Oncology - Northeast Texas	Allen	Texas	75013	Recruiting
Texas Oncology - West Texas	Amarillo	Texas	79124	Recruiting
Texas Oncology - Central/South Texas	Austin	Texas	78758	Recruiting
Texas Oncology - Gulf Coast	Beaumont	Texas	77702	Recruiting
Texas Oncology - Northeast Texas	Denison	Texas	75020	Recruiting
Texas Oncology - Northeast Texas	Denton	Texas	76201	Recruiting
Texas Oncology - West Texas	El Paso	Texas	79902	Recruiting
Texas Oncology - West Texas	El Paso	Texas	79915	Recruiting
Texas Oncology - West Texas	El Paso	Texas	79938	Recruiting
Texas Oncology - Northeast Texas	Flower Mound	Texas	75028	Recruiting
Texas Oncology - Central/South Texas	Harlingen	Texas	78550	Recruiting
Texas Oncology - Gulf Coast	Houston	Texas	77024	Recruiting
Texas Oncology - Gulf Coast	Houston	Texas	77054	Recruiting
Texas Oncology - Gulf Coast	Houston	Texas	77070	Recruiting
Texas Oncology - Gulf Coast	Humble	Texas	77338	Recruiting
US Oncology Investigational Products Center (IPC)	Irving	Texas	75063	Recruiting
US Oncology Investigational Products Center	Irving	Texas	75063	Recruiting
Texas Oncology - Northeast Texas	Lewisville	Texas	75056	Recruiting
Texas Oncology - Northeast Texas	Longview	Texas	75601	Recruiting
Texas Oncology - Central/South Texas	McAllen	Texas	78503	Recruiting
Texas Oncology - Northeast Texas	McKinney	Texas	75071	Recruiting
Texas Oncology - West Texas	Midland	Texas	79701	Recruiting
Texas Oncology - West Texas	Odessa	Texas	79761	Recruiting
Texas Oncology - Northeast Texas	Palestine	Texas	75801	Recruiting
Texas Oncology - Northeast Texas	Paris	Texas	75460	Recruiting
Texas Oncology - Gulf Coast	Pearland	Texas	77584	Recruiting
Texas Oncology - Gulf Coast	Sugar Land	Texas	77479	Recruiting
Texas Oncology - Gulf Coast	The Woodlands	Texas	77380	Recruiting
Texas Oncology - Northeast Texas	Tyler	Texas	75702	Recruiting
Texas Oncology - Central/South Texas	Waco	Texas	76712	Recruiting
Texas Oncology - Gulf Coast	Webster	Texas	77598	Recruiting
Texas Oncology - Central/South Texas	Weslaco	Texas	78596	Recruiting
Texas Oncology - West Texas	Wichita Falls	Texas	76310	Recruiting
Northwest Cancer Specialists - Vancouver	Vancouver	Washington	98684	Recruiting
Minnesota Oncology Hematology, P.A.	Hudson	Wisconsin	54016	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 78 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07222566, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 19, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07222566 live on ClinicalTrials.gov.

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