ClinicalTrials.gov record
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
ClinicalTrials.gov ID: NCT07222800
Public ClinicalTrials.gov record NCT07222800. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 10, 2026, 10:31 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL, PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS BEVACIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN TREATMENT-NAÏVE PARTICIPANTS WITH METASTATIC COLORECTAL CANCER
Study identification
- NCT ID
- NCT07222800
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 800 participants
Conditions and interventions
Conditions
Interventions
- Bevacizumab Biological
- Chemotherapy Drug
- PF-08634404 Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 10, 2025
- Primary completion
- Mar 28, 2030
- Completion
- Jul 31, 2031
- Last update posted
- Apr 20, 2026
2025 – 2031
United States locations
- U.S. sites
- 109
- U.S. states
- 16
- U.S. cities
- 94
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | Recruiting |
| Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | Recruiting |
| Ironwood Cancer & Research Centers | Glendale | Arizona | 85306 | Recruiting |
| Ironwood Cancer & Research Centers | Goodyear | Arizona | 85395 | Recruiting |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | Recruiting |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | Recruiting |
| Ironwood Cancer & Research Centers | Phoenix | Arizona | 85028 | Recruiting |
| Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | Recruiting |
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | Recruiting |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | Recruiting |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | Recruiting |
| Rocky Mountain Cancer Centers - Boulder | Boulder | Colorado | 80303 | Recruiting |
| Intermountain Health Cancer Center Saint Joseph | Denver | Colorado | 80218 | Not yet recruiting |
| Intermountain Health Saint Joseph Hospital - Research Office | Denver | Colorado | 80218 | Not yet recruiting |
| Intermountain Health Saint Joseph Hospital | Denver | Colorado | 80218 | Not yet recruiting |
| Florida Cancer Specialists | Bonita Springs | Florida | 34135 | Recruiting |
| Florida Cancer Specialists | Bradenton | Florida | 34211 | Recruiting |
| Florida Cancer Specialists | Cape Coral | Florida | 33909 | Recruiting |
| BRCR Global - Coral Springs | Coral Springs | Florida | 33065 | Recruiting |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | Recruiting |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | Recruiting |
| Cancer Care Centers of Brevard, Inc. | Melbourne | Florida | 32935 | Recruiting |
| Florida Cancer Specialists | N. Venice | Florida | 34275 | Recruiting |
| Florida Cancer Specialists | Naples | Florida | 34102 | Recruiting |
| Mid Florida Hematology and Oncology Center | Orange City | Florida | 32763 | Recruiting |
| Cancer Care Centers of Brevard, Inc. | Palm Bay | Florida | 32909 | Recruiting |
| Florida Cancer Specialists | Port Charlotte | Florida | 33980 | Recruiting |
| Cancer Care Centers of Brevard, Inc. | Rockledge | Florida | 32955 | Recruiting |
| Florida Cancer Specialists | Sarasota | Florida | 34236 | Recruiting |
| Illinois Cancer Specialists | Arlington Heights | Illinois | 60005 | Recruiting |
| Illinois CancerCare - Bloomington | Bloomington | Illinois | 61704 | Recruiting |
| Illinois Cancer Specialists | Chicago | Illinois | 60631 | Recruiting |
| Illinois CancerCare - Galesburg | Galesburg | Illinois | 61401 | Recruiting |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | Recruiting |
| Hope and Healing Cancer Services | New Lenox | Illinois | 60451 | Recruiting |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | Recruiting |
| Illinois CancerCare-Ottawa-Fox River Cancer Center | Ottawa | Illinois | 61350 | Recruiting |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | Recruiting |
| Illinois Cancer Care | Peoria | Illinois | 61615 | Recruiting |
| Illinois CancerCare-Peru - Valley Regional Cancer Center | Peru | Illinois | 61354 | Recruiting |
| Illinois CancerCare-Washington | Washington | Illinois | 61571 | Recruiting |
| The Cancer & Hematology Centers | Big Rapids | Michigan | 49307 | Recruiting |
| The Cancer & Hematology Centers | Grand Rapids | Michigan | 49503 | Recruiting |
| The Cancer & Hematology Centers | Grand Rapids | Michigan | 49546 | Recruiting |
| The Cancer & Hematology Centers | Holland | Michigan | 49424 | Recruiting |
| The Cancer & Hematology Centers | Norton Shores | Michigan | 49444 | Recruiting |
| Avera Cancer Institute- Marshall | Marshall | Minnesota | 56258 | Recruiting |
| Cancer Partners of Nebraska | Lincoln | Nebraska | 68516 | Recruiting |
| Renown Regional Medical Center | Reno | Nevada | 89502 | Recruiting |
| Hematology-Oncology Associates of Central New York, PC | Camillus | New York | 13031 | Recruiting |
| Hematology-Oncology Associates of Central New York, PC | East Syracuse | New York | 13057 | Recruiting |
| Hematology Oncology Associates of Rockland | Nyack | New York | 10960 | Recruiting |
| Oncology Hematology Care - Eastgate | Cincinnati | Ohio | 45245 | Recruiting |
| Oncology Hematology Care Clinical Trials, LLC | Fairfield | Ohio | 45014 | Recruiting |
| Oncology Associates of Oregon, P.C. | Albany | Oregon | 97321 | Recruiting |
| Kaiser Permanente Sunnyside Medical Center | Clackamas | Oregon | 97015 | Not yet recruiting |
| Oncology Associates of Oregon, P.C. | Corvallis | Oregon | 97330 | Recruiting |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | Recruiting |
| Kaiser Permanente Westside Medical Center | Hillsboro | Oregon | 97124 | Not yet recruiting |
| Kaiser Permanente Interstate Medical Office Central | Portland | Oregon | 97227 | Not yet recruiting |
| Oncology Associates of Oregon, P.C. | Springfield | Oregon | 97477 | Recruiting |
| Avera Cancer Institute- Aberdeen | Aberdeen | South Dakota | 57401 | Recruiting |
| Avera Cancer Institute- Mitchell | Mitchell | South Dakota | 57301 | Recruiting |
| Avera Cancer Institute- Pierre | Pierre | South Dakota | 57501 | Recruiting |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | Recruiting |
| AMG Oncology & Hematology -Yankton | Yankton | South Dakota | 57078 | Recruiting |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | Not yet recruiting |
| Texas Oncology - West Texas | Abilene | Texas | 79606 | Recruiting |
| Texas Oncology - West Texas | Amarillo | Texas | 79124 | Recruiting |
| Texas Oncology - Gulf Coast | Beaumont | Texas | 77702 | Recruiting |
| Texas Oncology - Northeast Texas | Denison | Texas | 75020 | Recruiting |
| Texas Oncology - Northeast Texas | Denton | Texas | 76201 | Recruiting |
| Texas Oncology - West Texas | El Paso | Texas | 79902 | Recruiting |
| Texas Oncology - West Texas | El Paso | Texas | 79915 | Recruiting |
| Texas Oncology - West Texas | El Paso | Texas | 79938 | Recruiting |
| Texas Oncology - Northeast Texas | Flower Mound | Texas | 75028 | Recruiting |
| Oncology Consultants P.A. | Houston | Texas | 77008 | Recruiting |
| Oncology Consultants P.A. | Houston | Texas | 77024 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77024 | Recruiting |
| Oncology Consultants P.A. | Houston | Texas | 77030 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77054 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77070 | Recruiting |
| Radnet/Houston Medical Imaging | Houston | Texas | 77098 | Recruiting |
| Texas Oncology - Gulf Coast | Humble | Texas | 77338 | Recruiting |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | Recruiting |
| US Oncology Investigational Products Center | Irving | Texas | 75063 | Recruiting |
| Texas Oncology - Northeast Texas | Longview | Texas | 75601 | Recruiting |
| Texas Oncology - West Texas | Midland | Texas | 79701 | Recruiting |
| Texas Oncology - West Texas | Odessa | Texas | 79761 | Recruiting |
| Texas Oncology - Gulf Coast | Pearland | Texas | 77584 | Recruiting |
| Texas Oncology - Gulf Coast | Sugar Land | Texas | 77479 | Recruiting |
| Texas Oncology - Gulf Coast | The Woodlands | Texas | 77380 | Recruiting |
| Texas Oncology - Northeast Texas | Tyler | Texas | 75702 | Recruiting |
| Texas Oncology - West Texas | Wichita Falls | Texas | 76310 | Recruiting |
| Virginia Cancer Specialists, PC | Arlington | Virginia | 22201 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | Recruiting |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | Recruiting |
| Virginia Cancer Specialists, PC | Manassas | Virginia | 20110 | Recruiting |
| Virginia Cancer Institute | Mechanicsville | Virginia | 23116 | Not yet recruiting |
| Virginia Cancer Institute | Midlothian | Virginia | 23112 | Not yet recruiting |
| Virginia Cancer Institute | Petersburg | Virginia | 23805 | Not yet recruiting |
| Virginia Cancer Specialists, PC | Reston | Virginia | 20190 | Recruiting |
| Virginia Cancer Institute | Richmond | Virginia | 23229 | Not yet recruiting |
| Virginia Cancer Institute | Richmond | Virginia | 23235 | Not yet recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Salem | Virginia | 24153 | Recruiting |
| Virginia Cancer Specialists, PC | Woodbridge | Virginia | 22191 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 47 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07222800, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 20, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07222800 live on ClinicalTrials.gov.