A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

ClinicalTrials.gov ID: NCT07223840

Public ClinicalTrials.gov record NCT07223840. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 10, 2026, 12:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Multicenter, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Brenipatide Compared With Placebo for Reduction in Risk of Relapse to Cigarette Smoking in Adults (RENEW-Smk-1)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study evaluates the efficacy and safety of brenipatide when compared to placebo for reducing the risk of relapse to cigarette smoking in adults who have recently quit. Study participation will last approximately 34 weeks with up to 17 study visits, which includes a 2-week screening period, 24-week treatment period, 8-week safety follow-up period.

Study identification

NCT ID: NCT07223840
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 222 participants

Conditions and interventions

Conditions

Smoking

Interventions

Brenipatide Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 2, 2025
Primary completion: Jan 31, 2027
Completion: Jan 31, 2027
Last update posted: Aug 20, 2026

2025 – 2027

United States locations

U.S. sites: 18
U.S. states: 12
U.S. cities: 18

Facility	City	State	ZIP	Site status
Woodland Research Northwest	Rogers	Arkansas	72758	Recruiting
Hillcrest Medical Research	DeLand	Florida	32720	Completed
TecTum Research	Hollywood	Florida	33024	Recruiting
K2 Medical Research ORLANDO	Maitland	Florida	32751	Recruiting
GTL Medical & Research Group	Miami	Florida	33173	Recruiting
Conquest Research - Orlando	Orlando	Florida	32832	Not yet recruiting
North Georgia Clinical Research	Woodstock	Georgia	30189	Recruiting
Revival Research Institute, LLC	Dearborn	Michigan	48126	Recruiting
Arch Clinical Trials	St Louis	Missouri	63141	Recruiting
Vector Clinical Trials	Las Vegas	Nevada	89128	Recruiting
Rochester Clinical Research, LLC	Rochester	New York	14609	Recruiting
Coastal Carolina Research Center	North Charleston	South Carolina	29405	Recruiting
Circle Clinical Research	Sioux Falls	South Dakota	57104	Recruiting
FutureSearch Trials of Dallas	Dallas	Texas	75251	Recruiting
Adams Clinical Dallas	DeSoto	Texas	75115	Not yet recruiting
The University of Texas Health Science Center at Houston	Houston	Texas	77054	Recruiting
Health Research of Hampton Roads, Inc.	Newport News	Virginia	23606	Recruiting
Eastside Research Associates	Redmond	Washington	98052	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07223840, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 20, 2026 · Synced Sep 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07223840 live on ClinicalTrials.gov.

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