A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
Public ClinicalTrials.gov record NCT07228390. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, 16-WEEK STUDY EVALUATING THE SAFETY AND EFFICACY OF RITLECITINIB (PF-06651600) IN ADULTS WITH MODERATE TO SEVERE HIDRADENITIS SUPPURATIVA
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn about the safety and effects of the study medicine (called Ritlecitinib) for the possible treatment of hidradenitis suppurativa (HS). HS is a disease causing long lasting painful red skin lumps. This study is seeking participants who: * have moderate or severe HS * have previously received antibiotics for HS that did not help, or could not tolerate antibiotics Participants will be randomly (like a flip of coin) assigned to receive either the study medicine or a placebo (a pill that looks like the study medicine but does not contain any medicine). The study medicine or placebo will be taken by mouth once daily at home. For the first part of the study, participants will receive a loading (starting) dose. For the next part of the study, participants will receive a maintenance (ongoing) dose. Participants will take part in the study for about 24 weeks (about 6 months). There will be about 10 study clinic visits: a screening visit, Day 1, and then every 1, 2, or 4 weeks until week 16. At each visit, participants will report on their health and have tests such as physical exams, blood and urine tests, vital signs, chest X-rays, ECGs, hearing tests, and questionnaires. Participants will record when they take the study medicine and their HS symptoms every day in an eDiary on a mobile phone. The experiences of participants receiving the study medicine will be compared to those receiving placebo to help see if the study medicine is safe and effective.
Study identification
- NCT ID
- NCT07228390
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 128 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 13, 2025 (Actual)
- Primary completion
- Dec 8, 2026 (Estimated)
- Completion
- Jan 5, 2027 (Estimated)
- Last update posted
- Oct 20, 2026
2025 – 2027
United States locations
- U.S. sites
- 30
- U.S. states
- 14
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Burke Pharmaceutical Research | Hot Springs | Arkansas | 71913 | — |
| First OC Dermatology Research Inc | Fountain Valley | California | 92708 | — |
| Northridge Clinical Trials | Northridge | California | 91325 | — |
| Integrative Skin Science and Research | Sacramento | California | 95815 | — |
| Wolverine Clinical Trials | Santa Ana | California | 92706 | — |
| Skin Care Research | Boca Raton | Florida | 33486 | — |
| Olympian Clinical Research | Largo | Florida | 33770 | — |
| Ziaderm Research LLC | North Miami Beach | Florida | 33162 | — |
| D&H Tamarac Research Center | Tamarac | Florida | 33321 | — |
| NMC Research LLC | Tampa | Florida | 33607 | — |
| USF - Carol and Frank Morsani Center for Advanced Healthcare-Clinical Research Center | Tampa | Florida | 33612 | — |
| Alliance Clinical Research of Tampa | Tampa | Florida | 33615 | — |
| Olympian Clinical Research | Tampa | Florida | 33615 | — |
| USF Florida Hearing Clinic | Tampa | Florida | 33620 | — |
| TruDerm & TruSpa | Wellington | Florida | 33449 | — |
| Advanced Medical Research, PC. | Sandy Springs | Georgia | 30328 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| The Indiana Clinical Trials Center, PC | Plainfield | Indiana | 46168 | — |
| Options Research Group | West Lafayette | Indiana | 47906 | — |
| Essential Medical Research - Overland Park | Overland Park | Kansas | 66213 | — |
| Skin and Hair Center | Overland Park | Kansas | 66213 | — |
| DS Research of Kentucky | Louisville | Kentucky | 40241 | — |
| Revival Research Institute, LLC | Southfield | Michigan | 48034 | — |
| Revival Research Institute, LLC | Troy | Michigan | 48084 | — |
| Stracskin | Portsmouth | New Hampshire | 03801 | — |
| ClinOhio Research Services | Columbus | Ohio | 43213 | — |
| Columbia Dermatology & Aesthetics | Columbia | South Carolina | 29212 | — |
| Palmetto Clinical Trial Services - Greenville | Greenville | South Carolina | 29615 | — |
| Center for Clinical Studies, LTD. LLP | Houston | Texas | 77004 | — |
| Eurofins CRL | Forest | Virginia | 24551 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07228390, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07228390 live on ClinicalTrials.gov.