A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Public ClinicalTrials.gov record NCT07277231. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-Label, Randomized Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Patients With Previously Untreated Chronic Lymphocytic Leukemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to investigate the efficacy and safety of fixed-duration sonrotoclax (also known as BGB-11417) plus zanubrutinib (also known as BGB-3111) (SZ) compared with fixed-duration of venetoclax plus acalabrutinib (AV) in participants with previously untreated chronic lymphocytic leukemia (CLL).
Study identification
- NCT ID
- NCT07277231
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 22, 2026 (Actual)
- Primary completion
- Feb 2031 (Estimated)
- Completion
- Nov 2031 (Estimated)
- Last update posted
- Sep 28, 2026
2026 – 2031
United States locations
- U.S. sites
- 22
- U.S. states
- 16
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope National Medical Center | Duarte | California | 91010-3012 | Recruiting |
| Chao Family Comprehensive Cancer Center | Orange | California | 92868-3201 | Recruiting |
| Stanford Cancer Institute | Palo Alto | California | 94304-2205 | Recruiting |
| Rocky Mountain Cancer Centers (Williams) Usor | Aurora | Colorado | 80012-5405 | Recruiting |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224-1865 | Recruiting |
| Mount Sinai Medical Center Braman Comprehensive Cancer Center | Miami | Florida | 33140 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612-9496 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Midwestern Regional Medical Center | Zion | Illinois | 60099-2676 | Recruiting |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121-2429 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215-5418 | Recruiting |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905-0001 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| Columbia University Medical Center | New York | New York | 10032 | Recruiting |
| Atrium Health Levine Cancer Institute (Lci) | Charlotte | North Carolina | 28204-2990 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27705-3976 | Recruiting |
| Oncology Associates of Oregon Willamette Valley Cancer Center | Eugene | Oregon | 97401 | Recruiting |
| Upmc Hillman Cancer Center(Univ of Pittsburgh) | Pittsburgh | Pennsylvania | 15232-1309 | Recruiting |
| Texas Oncology Tyler | Tyler | Texas | 75702-7522 | Recruiting |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112-5550 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109-4433 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226-3522 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 93 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07277231, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07277231 live on ClinicalTrials.gov.