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Recruiting Phase 3 Interventional Accepts healthy volunteers

A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

ClinicalTrials.gov ID: NCT07282665

Public ClinicalTrials.gov record NCT07282665. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 8:57 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 3, PLACEBO-CONTROLLED, DOUBLE-BLINDED, RANDOMIZED STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF A CLOSTRIDIOIDES DIFFICILE VACCINE IN ADULTS 65 YEARS OF AGE AND OLDER

Study identification

NCT ID
NCT07282665
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Pfizer
Industry
Enrollment
32,000 participants

Conditions and interventions

Interventions

  • C.difficile vaccine Biological
  • Saline Placebo Other

Biological · Other

Eligibility (public fields only)

Age range
65 Years and older
Sex
All
Healthy volunteers
Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 9, 2025
Primary completion
Dec 10, 2028
Completion
Jun 6, 2029
Last update posted
Apr 21, 2026

2025 – 2029

United States locations

U.S. sites
130
U.S. states
30
U.S. cities
91
Facility City State ZIP Site status
North Alabama Research Center Athens Alabama 35611 Recruiting
Lakeview Clinical Research Guntersville Alabama 35976 Recruiting
Medical Affiliated Research Center Huntsville Alabama 35801 Recruiting
Epic Medical Research-Sun City Sun City Arizona 85351 Recruiting
Applied Research Center of Arkansas Little Rock Arkansas 72205 Recruiting
Kaiser Permanente Daly City Daly City California 94015 Recruiting
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 Recruiting
Kaiser Permanente Oncology Pharmacy #014C Los Angeles California 90027 Recruiting
Sacramento VA Medical Center Mather California 95655 Not yet recruiting
Kaiser Permanente Oakland Oakland California 94611 Not yet recruiting
Kaiser Permanente Ontario Medical Center Ontario California 91761 Recruiting
Kaiser Permanente Roseville Roseville California 95661 Recruiting
Kaiser Permanente Sacramento Sacramento California 95815 Recruiting
Kaiser Permanente South Sacramento Sacramento California 95823 Recruiting
Velocity Clinical Research, San Bernardino San Bernardino California 92408 Recruiting
Kaiser Permanente - San Diego Medical Center San Diego California 92123 Recruiting
Kaiser Permanente Viewridge Medical Office San Diego California 92123 Recruiting
Kaiser Permanente San Jose San Jose California 95119 Recruiting
Carbon Health - San Mateo - Hillsdale Mall San Mateo California 94403 Recruiting
Kaiser Permanente Santa Clara Santa Clara California 95051 Recruiting
Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc. Toluca Lake California 91602 Recruiting
Kaiser Permanente Walnut Creek Walnut Creek California 94596 Recruiting
Diablo Clinical Research, Inc. Walnut Creek California 94598 Recruiting
GW Vaccine Research Unit Washington D.C. District of Columbia 20037 Recruiting
The GW Medical Faculty Associates Washington D.C. District of Columbia 20037 Recruiting
Bay Pines VA Healthcare System Bay Pines Florida 33744 Not yet recruiting
Proactive Clinical Research,LLC Fort Lauderdale Florida 33308 Recruiting
Indago Research & Health Center, Inc Hialeah Florida 33012 Recruiting
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare Jacksonville Florida 32256 Recruiting
M3 Wake Research - Lake City Lake City Florida 32055 Recruiting
South Florida Research Organization Medley Florida 33166 Recruiting
Care Research Inc Miami Florida 33130 Recruiting
Entrust Clinical Research Miami Florida 33176 Recruiting
Charisma Medical and Research Center Miami Lakes Florida 33014 Recruiting
Palm Springs Community Health Center Miami Lakes Florida 33014 Not yet recruiting
Innovation Medical Research Center Palmetto Bay Florida 33157 Not yet recruiting
Angels Clinical Research Institute Tampa Florida 33614 Recruiting
Emory Steiner Building Research Center Atlanta Georgia 30303 Not yet recruiting
Emory University Woodruff Extension Building (WEB) Atlanta Georgia 30303 Not yet recruiting
Centricity Research Columbus Georgia Multispecialty Columbus Georgia 31904 Recruiting
The Hope Clinic of Emory University Decatur Georgia 30030 Recruiting
Velocity Clinical Research, Savannah Savannah Georgia 31406 Recruiting
DM Clinical Research - Chicago Melrose Park Illinois 60160 Recruiting
Accellacare - McFarland Ames Iowa 50010 Recruiting
McFarland Clinic, PC Ames Iowa 50010 Recruiting
Velocity Clinical Research, Sioux City Sioux City Iowa 51106 Recruiting
AMR Clinical Newton Kansas 67114 Recruiting
Ochsner Medical Complex - The Grove Baton Rouge Louisiana 70836 Not yet recruiting
Ochsner Clinic Foundation - Kenner Clinical Trials Unit Kenner Louisiana 70065 Not yet recruiting
Ochsner Lafayette General Medical Center Lafayette Louisiana 70503 Not yet recruiting
Johns Hopkins Bloomberg School of Public Health Baltimore Maryland 21205 Not yet recruiting
Revive Research Institute, Inc. Southfield Michigan 48075 Recruiting
DM Clinical Research - Detroit Southfield Michigan 48076 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Sundance Clinical Research St Louis Missouri 63141 Recruiting
Velocity Clinical Research, Grand Island Grand Island Nebraska 68803 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68105 Not yet recruiting
Velocity Clinical Research, Omaha Omaha Nebraska 68134 Recruiting
University Of Nebraska Medical Center Omaha Nebraska 68198 Not yet recruiting
Renown Center for Advanced Medicine Reno Nevada 89502 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Recruiting
University Health Reno Nevada 89519 Recruiting
Hackensack Meridian Health Hackensack University Medical Center Hackensack New Jersey 07601 Recruiting
HMH David Jurist Research Building Hackensack New Jersey 07601 Recruiting
HMH Hackensack University Medical Center Hackensack New Jersey 07601 Recruiting
Hackensack Meridian Jersey Shore University Medical Center Neptune City New Jersey 07753 Recruiting
HOPE Tower at Jersey Shore University Medical Center Neptune City New Jersey 07753 Recruiting
Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey 08901 Not yet recruiting
South Jersey Infectious Disease Somers Point New Jersey 08244 Recruiting
Albuquerque Clinical Trials, Inc. Albuquerque New Mexico 87102 Recruiting
NYU Langone Health Brooklyn New York 11220 Recruiting
Upstate Global Health Institute East Syracuse New York 13057 Recruiting
Mount Sinai Queens Long Island City New York 11102 Recruiting
North Shore University Hospital Manhasset New York 11030 Recruiting
Northwell Health Infectious Disease Manhasset New York 11030 Recruiting
NYU Langone Health Mineola New York 11501 Recruiting
Northern Westchester Hospital Mount Kisco New York 10549 Recruiting
NYU Langone Health New York New York 10016 Recruiting
Mount Sinai West New York New York 10019 Recruiting
Mount Sinai Morningside New York New York 10025 Recruiting
Icahn School of Medicine at Mount Sinai New York New York 10029 Recruiting
Columbia University Irving Medical Center New York New York 10032 Not yet recruiting
Rochester Clinical Research, LLC Rochester New York 14609 Recruiting
Phelps Hospital Geriatric Medicine & Improvement Science Sleepy Hollow New York 10591 Recruiting
Montefiore Medical Center The Bronx New York 10467 Recruiting
Accellacare - Cary Cary North Carolina 27518 Recruiting
Duke Vaccine and Trials Unit Durham North Carolina 27703 Recruiting
Medication Management Greensboro North Carolina 27405 Recruiting
Accellacare - Hickory Hickory North Carolina 28601 Recruiting
Atrium Health Wake Forest Baptist Infectious Disease-High Point High Point North Carolina 27262 Recruiting
Accellacare - Raleigh Raleigh North Carolina 27609 Recruiting
Duke University Health System Raleigh North Carolina 27609 Recruiting
Accellacare - Salisbury Salisbury North Carolina 28144 Recruiting
Accellacare - Wilmington Wilmington North Carolina 28401 Recruiting
Accellacare - Winston-Salem Winston-Salem North Carolina 27103 Recruiting
Wake Forest Baptist Health Winston-Salem North Carolina 27157 Recruiting
CTI Clinical Research Center Cincinnati Ohio 45212 Recruiting
VA Northeast Ohio Healthcare System Louis Stokes Cleveland VA Medical Center Cleveland Ohio 44106 Recruiting
Kaiser Permanente Center for Health Research Portland Oregon 97227 Recruiting
Capital Area Research, LLC Camp Hill Pennsylvania 17011 Recruiting
DM Clinical Research - Philadelphia Philadelphia Pennsylvania 19107 Recruiting
Walker Family Care Little River South Carolina 29566 Recruiting
Trial Management Associates, LLC Myrtle Beach South Carolina 29572 Recruiting
Trial Management Associates Myrtle Beach South Carolina 29572 Recruiting
Velocity Clinical Research, Spartanburg Spartanburg South Carolina 29303 Recruiting
New Phase Research and Development Knoxville Tennessee 37909 Recruiting
Clinical Neuroscience Solutions Inc. Memphis Tennessee 38119 Recruiting
The Vanderbilt Vaccine Research Program Clinic at The Village at Vanderbilt Nashville Tennessee 37212 Not yet recruiting
Vanderbilt Investigational Drug Service (IDS) Nashville Tennessee 37232 Not yet recruiting
Vanderbilt University Medical Center Nashville Tennessee 37232 Not yet recruiting
Vanderbilt Vaccine Research Program Laboratory Nashville Tennessee 37232 Not yet recruiting
Vanderbilt Vaccine Research Program Nashville Tennessee 37232 Not yet recruiting
Family Health Watch - KeyPoint Clinical Research Dallas Texas 75237 Recruiting
KeyPoint Clinical Research Dallas Texas 75240 Recruiting
North Texas Infectious Diseases Consultants, P.A Dallas Texas 75246 Recruiting
Cedar Health Research - Euless Euless Texas 76040 Recruiting
Memorial Hermann Hospital - TMC Houston Texas 77030 Not yet recruiting
The University of Texas Health Science Center at Houston Houston Texas 77030 Not yet recruiting
UT Physicians Houston Texas 77030 Not yet recruiting
DM Clinical Research- Cyfair Houston Texas 77065 Recruiting
Mercury Clinical Research - Santa Clara Family Clinic Houston Texas 77087 Recruiting
Dynamed Clinical Research, LP d/b/a DM Clinical Research Tomball Texas 77375 Recruiting
Northwest Houston Heart Center Tomball Texas 77375 Recruiting
J. Lewis Research, Inc. / Foothill Family Clinic South Salt Lake City Utah 84121 Recruiting
The University of Vermont Medical Center Inc. Burlington Vermont 05401 Not yet recruiting
UVM Larner College of Medicine MMG/VCT Burlington Vermont 05401 Not yet recruiting
Clinical Research Partners, LLC Richmond Virginia 23226 Not yet recruiting
Providence Regional Medical Center Everett Everett Washington 98201 Not yet recruiting
Kaiser Permanente Washington Health Research Institute (KPWHRI) Seattle Washington 98101 Not yet recruiting
University of Washington - Harborview Medical Center Seattle Washington 98104 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 28 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07282665, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 21, 2026 · Synced Apr 29, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07282665 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →