A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease
Public ClinicalTrials.gov record NCT07284381. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-masked, Randomized Study to Compare the Efficacy and Safety of the ABBV-444 Tear Formulation With REFRESH OPTIVE® Unit Dose in Patients With Dry Eye Disease
Study identification
- NCT ID
- NCT07284381
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 261 participants
Conditions and interventions
Conditions
Interventions
- ABBV-444 Drug
- REFRESH OPTIVE UD Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2025
- Primary completion
- Jul 31, 2026
- Completion
- Jul 31, 2026
- Last update posted
- Jun 16, 2026
2025 – 2026
United States locations
- U.S. sites
- 20
- U.S. states
- 14
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Trinity Research Group /ID# 279914 | Dothan | Alabama | 36301 | — |
| Arizona Eye Center - West Ray Road /ID# 267993 | Chandler | Arizona | 85224 | — |
| Canyon City Eyecare /ID# 267948 | Azusa | California | 91702 | — |
| Global Research Management /ID# 267980 | Glendale | California | 91204 | — |
| Lakeside Vision Center /ID# 268544 | Irvine | California | 92604 | — |
| Eye Research Foundation /ID# 267931 | Newport Beach | California | 92663 | — |
| Lee Shettle Eye and Hearing /ID# 268118 | Largo | Florida | 33773 | — |
| Clayton Eye Center /ID# 268097 | Morrow | Georgia | 30260 | — |
| Coastal Research Associates - Roswell /ID# 279915 | Roswell | Georgia | 30076 | — |
| Kannarr Eye Care /ID# 267979 | Pittsburg | Kansas | 66762 | — |
| Butchertown Clinical Trials /ID# 267887 | Louisville | Kentucky | 40206 | — |
| Moyes Eye Centers /ID# 267944 | Kansas City | Missouri | 64154 | — |
| Northern New Jersey Eye Institute /ID# 267974 | South Orange | New Jersey | 07079 | — |
| Rochester Ophthalmological Group - Rochester /ID# 268374 | Rochester | New York | 14618 | — |
| Core Inc /ID# 267946 | Shelby | North Carolina | 28150 | — |
| Scott and Christie and Associates /ID# 268119 | Cranberry Township | Pennsylvania | 16066 | — |
| Southern College of Optometry /ID# 267971 | Memphis | Tennessee | 38104 | — |
| Total Eye Care - Memphis /ID# 268327 | Memphis | Tennessee | 38119 | — |
| Advancing Vision Research - Smyrna - Stonecrest Parkway /ID# 267939 | Smyrna | Tennessee | 37167 | — |
| Piedmont Eye Center /ID# 267929 | Lynchburg | Virginia | 24502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07284381, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 16, 2026 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07284381 live on ClinicalTrials.gov.