Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

ClinicalTrials.gov ID: NCT07383441

Public ClinicalTrials.gov record NCT07383441. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 20, 2026, 7:11 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Double Blinded Trial of Immune-Based Therapy With a Live Biotherapeutic MO-03 or Placebo for Frontline Therapy of Advanced Clear Cell Renal Cell Carcinoma [BioFront Trial]

Study identification

NCT ID: NCT07383441
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: SWOG Cancer Research Network; Network
Enrollment: 718 participants

Conditions and interventions

Conditions

Interventions

Axitinib Drug
Biospecimen Collection Procedure
Bone Scan Procedure
Cabozantinib Drug
Clostridium butyricum CBM 588 Probiotic Strain Drug
Computed Tomography Procedure
Ipilimumab Biological
Lenvatinib Drug
Magnetic Resonance Imaging Procedure
Nivolumab Biological
Nivolumab and Recombinant Human Hyaluronidase Drug
Pembrolizumab Biological
Placebo Administration Drug

Drug · Procedure · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 4, 2026
Primary completion: Jan 30, 2033
Completion: Jan 30, 2034
Last update posted: Jun 10, 2026

2026 – 2034

United States locations

U.S. sites: 41
U.S. states: 8
U.S. cities: 39

Facility	City	State	ZIP	Site status
Highlands Oncology Group - Fayetteville	Fayetteville	Arkansas	72703	Recruiting
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	72401	Recruiting
Highlands Oncology Group - Rogers	Rogers	Arkansas	72758	Recruiting
Highlands Oncology Group	Springdale	Arkansas	72762	Recruiting
Illinois CancerCare-Bloomington	Bloomington	Illinois	61704	Recruiting
Illinois CancerCare-Canton	Canton	Illinois	61520	Recruiting
Illinois CancerCare-Carthage	Carthage	Illinois	62321	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Illinois CancerCare-Eureka	Eureka	Illinois	61530	Recruiting
Illinois CancerCare-Galesburg	Galesburg	Illinois	61401	Recruiting
Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	61443	Recruiting
Illinois CancerCare-Macomb	Macomb	Illinois	61455	Recruiting
Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	61350	Recruiting
Illinois CancerCare-Pekin	Pekin	Illinois	61554	Recruiting
Illinois CancerCare-Peoria	Peoria	Illinois	61615	Recruiting
Illinois CancerCare-Peru	Peru	Illinois	61354	Recruiting
Illinois CancerCare-Princeton	Princeton	Illinois	61356	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Illinois CancerCare - Washington	Washington	Illinois	61571	Recruiting
Mercy Hospital	Cedar Rapids	Iowa	52403	Recruiting
Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	52403	Recruiting
Lahey Hospital and Medical Center	Burlington	Massachusetts	01805	Recruiting
Lahey Medical Center-Peabody	Peabody	Massachusetts	01960	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	39705	Recruiting
Baptist Cancer Center-Grenada	Grenada	Mississippi	38901	Recruiting
Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	38652	Recruiting
Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	38655	Recruiting
Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	38671	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Parkland Health Center - Farmington	Farmington	Missouri	63640	Recruiting
Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	63670	Recruiting
Missouri Baptist Medical Center	St Louis	Missouri	63131	Recruiting
Missouri Baptist Sullivan Hospital	Sullivan	Missouri	63080	Recruiting
Baptist Memorial Hospital and Cancer Center-Collierville	Collierville	Tennessee	38017	Recruiting
Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	38120	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07383441, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 10, 2026 · Synced Jul 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07383441 live on ClinicalTrials.gov.

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