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Recruiting Phase 3 Interventional

Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial

ClinicalTrials.gov ID: NCT07388524

Public ClinicalTrials.gov record NCT07388524. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 25, 2026, 3:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Evaluating Adjuvant Atezolizumab or Atezolizumab and Hyaluronidase-TQJS to Prevent Recurrence in Stage I Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase III Trial (AASI-NSCLC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares the effect of atezolizumab (or atezolizumab and recombinant human hyaluronidase) to standard observation for preventing cancer return after surgery (recurrence) in patients who have undergone a complete surgical removal (resection) of stage I non-small cell lung cancer (NSCLC). Patients who have undergone resection for lung cancer are typically followed by observation or active surveillance, which involves closely watching a patient's condition but not giving treatment unless there are changes in test results. During active surveillance, patients are given certain exams and tests done on a regular schedule. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Atezolizumab and recombinant human hyaluronidase is a formulation of atezolizumab combined with an enzyme called hyaluronidase, which helps increase tissue absorption of the drug. Giving atezolizumab or atezolizumab and recombinant human hyaluronidase after resection may be effective for preventing NSCLC recurrence, and may be a better approach to treating patients with stage I NSCLC than the usual observation approach.

Study identification

NCT ID
NCT07388524
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
336 participants

Conditions and interventions

Interventions

Biological · Procedure · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 2, 2027 (Estimated)
Primary completion
Sep 30, 2032 (Estimated)
Completion
Sep 30, 2032 (Estimated)
Last update posted
Oct 23, 2026

2027 – 2032

United States locations

U.S. sites
108
U.S. states
19
U.S. cities
93
Facility City State ZIP Site status
Tower Cancer Research Foundation Beverly Hills California 90211 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
Cedars-Sinai Cancer - Tarzana Tarzana California 91356 Recruiting
Torrance Memorial Physician Network - Cancer Care Torrance California 90505 Recruiting
Beebe South Coastal Health Campus Millville Delaware 19967 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
Beebe Health Campus Rehoboth Beach Delaware 19971 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Recruiting
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Carle BroMenn Medical Center Normal Illinois 61761 Recruiting
Carle Cancer Institute Normal Normal Illinois 61761 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
HSHS Saint Elizabeth's Hospital O'Fallon Illinois 62269 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
Northwest Cancer Center - Crown Point Crown Point Indiana 46307 Recruiting
Northwest Oncology LLC Dyer Indiana 46311 Recruiting
Saint Mary Medical Center Hobart Indiana 46342 Recruiting
Saint Catherine Hospital Indianapolis Indiana 46312 Recruiting
The Community Hospital Munster Indiana 46321 Recruiting
Women's Diagnostic Center - Munster Munster Indiana 46321 Recruiting
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
Physicians' Clinic of Iowa PC Cedar Rapids Iowa 52402 Recruiting
Mercy Hospital Cedar Rapids Iowa 52403 Recruiting
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403 Recruiting
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 Recruiting
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 Recruiting
Owensboro Health Mitchell Memorial Cancer Center Owensboro Kentucky 42303 Recruiting
Bronson Battle Creek Battle Creek Michigan 49017 Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 Recruiting
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids Michigan 49503 Recruiting
Bronson Methodist Hospital Kalamazoo Michigan 49007 Recruiting
West Michigan Cancer Center Kalamazoo Michigan 49007 Recruiting
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120 Recruiting
Corewell Health Reed City Hospital Reed City Michigan 49677 Recruiting
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 Recruiting
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085 Recruiting
Munson Medical Center Traverse City Michigan 49684 Recruiting
University of Michigan Health - West Wyoming Michigan 49519 Recruiting
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 Recruiting
Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Essentia Health - Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota 56501 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Saint Francis Medical Center Cape Girardeau Missouri 63703 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Bozeman Health Deaconess Hospital Bozeman Montana 59715 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Logan Health Medical Center Kalispell Montana 59901 Recruiting
Community Medical Center Missoula Montana 59804 Recruiting
Ocean University Medical Center Brick New Jersey 08724 Recruiting
Southern Ocean County Medical Center Manahawkin New Jersey 08050 Recruiting
Jersey Shore Medical Center Neptune City New Jersey 07753 Recruiting
Riverview Medical Center/Booker Cancer Center Red Bank New Jersey 07701 Recruiting
Roswell Park Cancer Institute Buffalo New York 14263 Recruiting
Hematology Oncology Associates of CNY at Camillus Camillus New York 13031 Recruiting
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse New York 13057 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina 28374 Recruiting
Essentia Health Cancer Center-South University Clinic Fargo North Dakota 58103 Recruiting
ProMedica Flower Hospital Sylvania Ohio 43560 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 Recruiting
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 Recruiting
Swedish Medical Center-First Hill Seattle Washington 98122 Recruiting
Duluth Clinic Ashland Ashland Wisconsin 54806 Recruiting
Bellin Memorial Hospital Green Bay Wisconsin 54301 Recruiting
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Recruiting
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151 Recruiting
Drexel Town Square Health Center Oak Creek Wisconsin 53154 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Recruiting
Essentia Health Saint Mary's Hospital - Superior Superior Wisconsin 54880 Recruiting
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07388524, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 23, 2026 · Synced Oct 25, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07388524 live on ClinicalTrials.gov.

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