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Recruiting Phase 3 Interventional

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

ClinicalTrials.gov ID: NCT07391774

Public ClinicalTrials.gov record NCT07391774. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 1, 2026, 7:40 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Trial of Rx Therapy Guided by Genomic Risk Assessment For High Anatomic Stage ER-pos/HER2-neg Breast Cancer With RS Less Than or Equal to 25 (RxFINE-Low)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the cancer returning (low risk recurrence). Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy, with letrozole, anastrozole or exemestane, lowers the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hormone therapy plus ribociclib may work as well as chemotherapy followed by hormone therapy plus ribociclib for the treatment of high anatomic stage breast cancer with low recurrence risk.

Study identification

NCT ID
NCT07391774
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
1,978 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 9, 2026
Primary completion
Jul 30, 2029
Completion
Jul 30, 2029
Last update posted
Aug 31, 2026

2026 – 2029

United States locations

U.S. sites
143
U.S. states
23
U.S. cities
121
Facility City State ZIP Site status
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro Arkansas 72401 Recruiting
Sutter Auburn Faith Hospital Auburn California 95602 Recruiting
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 Recruiting
Tower Cancer Research Foundation Beverly Hills California 90211 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
Palo Alto Medical Foundation Health Care Palo Alto California 94301 Recruiting
Sutter Roseville Medical Center Roseville California 95661 Recruiting
Sutter Medical Center Sacramento Sacramento California 95816 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
California Pacific Medical Center-Pacific Campus San Francisco California 94115 Recruiting
Mills Health Center San Mateo California 94401 Recruiting
Ridley-Tree Cancer Center Santa Barbara California 93105 Recruiting
Cedars-Sinai Cancer - Tarzana Tarzana California 91356 Recruiting
Sutter Solano Medical Center/Cancer Center Vallejo California 94589 Recruiting
UCI Health - Yorba Linda Yorba Linda California 92886 Recruiting
Stamford Hospital/Bennett Cancer Center Stamford Connecticut 06904 Recruiting
Beebe South Coastal Health Campus Millville Delaware 19967 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
Beebe Health Campus Rehoboth Beach Delaware 19971 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Recruiting
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
SIH Cancer Institute Carterville Illinois 62918 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
Northwestern Medicine Cancer Center Old Irving Park Chicago Illinois 60641 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 Recruiting
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 Recruiting
Northwestern Medicine Glenview Outpatient Center Glenview Illinois 60026 Recruiting
Northwestern Medicine Grayslake Outpatient Center Grayslake Illinois 60030 Recruiting
Northwestern Medicine Huntley Hospital Huntley Illinois 60142 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Northwestern Medicine McHenry Hospital McHenry Illinois 60050 Recruiting
SSM Health Good Samaritan Mount Vernon Illinois 62864 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
HSHS Saint Elizabeth's Hospital O'Fallon Illinois 62269 Recruiting
Northwestern Medicine Oak Brook Oak Brook Illinois 60523 Recruiting
Northwestern Medicine Orland Park Orland Park Illinois 60462 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
Saint Anthony Regional Hospital Carroll Iowa 51401 Recruiting
Mercy Hospital Cedar Rapids Iowa 52403 Recruiting
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Broadlawns Medical Center Des Moines Iowa 50314 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 Recruiting
UI Healthcare Mission Cancer and Blood - Fort Dodge Fort Dodge Iowa 50501 Recruiting
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
University of Kansas Health System Saint Francis Campus Topeka Kansas 66606 Recruiting
UM Upper Chesapeake Hematology and Oncology - Aberdeen Aberdeen Maryland 21001 Recruiting
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201 Recruiting
Greater Baltimore Medical Center Baltimore Maryland 21204 Recruiting
UM Upper Chesapeake Medical Center Bel Air Maryland 21014 Recruiting
University of Maryland Shore Medical Center at Easton Easton Maryland 21601 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 Recruiting
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 Recruiting
Essentia Health - Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota 56501 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Miller-Dwan Hospital Duluth Minnesota 55805 Recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Saint Francis Regional Medical Center Shakopee Minnesota 55379 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi 39705 Recruiting
Baptist Cancer Center-Grenada Grenada Mississippi 38901 Recruiting
Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi 38652 Recruiting
Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi 38655 Recruiting
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi 38671 Recruiting
Saint Francis Medical Center Cape Girardeau Missouri 63703 Recruiting
Parkland Health Center - Farmington Farmington Missouri 63640 Recruiting
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 Recruiting
Missouri Baptist Medical Center St Louis Missouri 63131 Recruiting
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Bozeman Health Deaconess Hospital Bozeman Montana 59715 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Community Medical Center Missoula Montana 59804 Recruiting
Jefferson Cherry Hill Hospital Cherry Hill New Jersey 08002 Recruiting
Sidney Kimmel Cancer Center Washington Township Sewell New Jersey 08080 Recruiting
Roswell Park Cancer Institute Buffalo New York 14263 Recruiting
Mount Sinai Chelsea New York New York 10011 Recruiting
Mount Sinai West New York New York 10019 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Good Samaritan University Hospital West Islip New York 11795 Recruiting
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 Recruiting
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 Recruiting
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 Recruiting
Essentia Health Cancer Center-South University Clinic Fargo North Dakota 58103 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
Jefferson Torresdale Hospital Philadelphia Pennsylvania 19114 Recruiting
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 Recruiting
Lexington Health West Columbia South Carolina 29169 Recruiting
Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee 38017 Recruiting
Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee 38120 Recruiting
Duluth Clinic Ashland Ashland Wisconsin 54806 Recruiting
Northwest Wisconsin Cancer Center Ashland Wisconsin 54806 Recruiting
Essentia Health-Hayward Clinic Hayward Wisconsin 54843 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Recruiting
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Recruiting
Essentia Health-Spooner Clinic Spooner Wisconsin 54801 Recruiting
Essentia Health Saint Mary's Hospital - Superior Superior Wisconsin 54880 Recruiting
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07391774, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 31, 2026 · Synced Sep 1, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07391774 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →