A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years

ClinicalTrials.gov ID: NCT07413666

Open the official record

This page only displays public information reproduced from the official ClinicalTrials.gov record NCT07413666. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:13 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Safety, Tolerability, Pharmacokinetic, Food Effect, and Proof-of-Concept Study of Single and Multiple Doses of ORX489 in Healthy Adults

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Characterize the safety, tolerability and pharmacokinetics of ORX489 following single and multiple doses.

Study identification

NCT ID: NCT07413666
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Centessa Pharmaceuticals (UK) Limited; Industry
Enrollment: 212 participants

Conditions and interventions

Conditions

Healthy Adult Male and Female Volunteers

Interventions

ORX489 Tablets Drug
Placebo Tablets Other

Drug · Other

Eligibility (public fields only)

Age range: 18 Years to 60 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 25, 2026 (Estimated)
Primary completion: Jun 30, 2027 (Estimated)
Completion: Jun 30, 2027 (Estimated)
Last update posted: Feb 25, 2026

2026 – 2027

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Celerion	Lincoln	Nebraska	68502	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07413666, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 25, 2026 · Synced Nov 15, 2026