LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Public ClinicalTrials.gov record NCT07415044. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Multicenter, Double-Blind, Placebo-Controlled Development Program to Evaluate the Efficacy and Safety of LY4268989 (MORF-057) for the Treatment of Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
Study identification
- NCT ID
- NCT07415044
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 1,431 participants
Conditions and interventions
Conditions
Interventions
- LY4268989 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 25, 2026
- Primary completion
- May 31, 2030
- Completion
- Jun 30, 2031
- Last update posted
- May 12, 2026
2026 – 2031
United States locations
- U.S. sites
- 48
- U.S. states
- 23
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Valleywise Health Medical Center | Phoenix | Arizona | 85008 | Not yet recruiting |
| One of a Kind Clinical Research Center | Scottsdale | Arizona | 85258 | Not yet recruiting |
| Clinnova Research | Anaheim | California | 92805 | Recruiting |
| GMC Clinical Research | Folsom | California | 95630 | Recruiting |
| Om Research LLC | Temple City | California | 91780 | Not yet recruiting |
| Om Research LLC | Victorville | California | 92395 | Not yet recruiting |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | Recruiting |
| Advanced Research Institute - Denver | Denver | Colorado | 80218 | Not yet recruiting |
| Rocky Mountain Gastroenterology Associates - Lakewood | Lakewood | Colorado | 80228 | Not yet recruiting |
| Medical Research Center of Connecticut | Hamden | Connecticut | 06518 | Not yet recruiting |
| K2 Medical Research - Daytona Beach | Daytona Beach | Florida | 32114 | Not yet recruiting |
| Clinical Research of Osceola | Kissimmee | Florida | 34741 | Recruiting |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | Recruiting |
| AdventHealth Orlando | Orlando | Florida | 32803 | Not yet recruiting |
| Treasure Valley Medical Research | Boise | Idaho | 83706 | Not yet recruiting |
| Grand Teton Research Group | Idaho Falls | Idaho | 83404 | Not yet recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Not yet recruiting |
| Rush University Medical Center | Chicago | Illinois | 60612 | Not yet recruiting |
| Midwest Digestive Health & Nutrition | Des Plaines | Illinois | 60016 | Recruiting |
| Springfield Clinic - First | Springfield | Illinois | 62702 | Recruiting |
| Gastroenterology Health Partners | New Albany | Indiana | 47150 | Recruiting |
| Gastroenterology Health Partners | Louisville | Kentucky | 40218 | Recruiting |
| Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center | Wyoming | Michigan | 49519 | Recruiting |
| Mayo Clinic in Rochester, Minnesota | Rochester | Minnesota | 55905 | Not yet recruiting |
| KAD Clinical Research | St Louis | Missouri | 63123 | Not yet recruiting |
| Digestive Disease Specialists - Las Vegas - Crimson Canyon Drive | Las Vegas | Nevada | 89128 | Not yet recruiting |
| Virtua Health & Wellness Center - Moorestown | Moorestown | New Jersey | 08057 | Not yet recruiting |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | Not yet recruiting |
| Stony Brook University | Stony Brook | New York | 11794 | Not yet recruiting |
| Carolina Digestive Diseases and Endoscopy Center | Greenville | North Carolina | 27834 | Recruiting |
| Wilmington Health, PLLC | Wilmington | North Carolina | 28401 | Recruiting |
| Ohio State University | Hilliard | Ohio | 43026 | Not yet recruiting |
| DSI Research - Springboro | Springboro | Ohio | 45066 | Not yet recruiting |
| The Oregon Clinic | Portland | Oregon | 97220 | Not yet recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Not yet recruiting |
| Sanford USD Medical Center | Sioux Falls | South Dakota | 57105 | Not yet recruiting |
| GI Alliance - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| GI Alliance - Garland | Garland | Texas | 75044 | Recruiting |
| Integrity Advanced Therapeutics | Houston | Texas | 77090 | Not yet recruiting |
| GI Alliance: Mansfield | Mansfield | Texas | 76063 | Recruiting |
| Southern Star Research Institute | San Antonio | Texas | 78229 | Not yet recruiting |
| GI Alliance - San Marcos | San Marcos | Texas | 78666 | Not yet recruiting |
| Tyler Research Institute | Tyler | Texas | 75701 | Not yet recruiting |
| Eximia Research-VA, LLC | Norfolk | Virginia | 23502 | Recruiting |
| Swedish Medical Center | Seattle | Washington | 98104 | Not yet recruiting |
| Principle Research Solutions | Spokane | Washington | 99202 | Not yet recruiting |
| Providence Sacred Heart Medical Center & Children's Hospital | Spokane | Washington | 99208 | Not yet recruiting |
| Washington Gastroenterology - Tacoma | Tacoma | Washington | 98405 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 204 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07415044, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 12, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07415044 live on ClinicalTrials.gov.