LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Public ClinicalTrials.gov record NCT07415044. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Multicenter, Double-Blind, Placebo-Controlled Development Program to Evaluate the Efficacy and Safety of LY4268989 (MORF-057) for the Treatment of Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally. The study will last up to approximately 108 weeks, excluding screening.
Study identification
- NCT ID
- NCT07415044
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,431 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 26, 2026 (Actual)
- Primary completion
- Jun 2030 (Estimated)
- Completion
- Jul 2031 (Estimated)
- Last update posted
- Oct 8, 2026
2026 – 2031
United States locations
- U.S. sites
- 52
- U.S. states
- 25
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Valleywise Health Medical Center | Phoenix | Arizona | 85008 | Recruiting |
| One of a Kind Clinical Research Center | Scottsdale | Arizona | 85258 | Not yet recruiting |
| Clinnova Research | Anaheim | California | 92805 | Recruiting |
| GMC Clinical Research | Folsom | California | 95630 | Recruiting |
| Om Research LLC | Temple City | California | 91780 | Recruiting |
| Om Research LLC | Victorville | California | 92395 | Recruiting |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | Recruiting |
| Advanced Research Institute - Denver | Denver | Colorado | 80218 | Suspended |
| Rocky Mountain Gastroenterology Associates - Lakewood | Lakewood | Colorado | 80228 | Recruiting |
| Medical Research Center of Connecticut | Hamden | Connecticut | 06518 | Not yet recruiting |
| K2 Medical Research - Daytona Beach | Daytona Beach | Florida | 32114 | Recruiting |
| Clinical Research of Osceola | Kissimmee | Florida | 34741 | Recruiting |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | Recruiting |
| AdventHealth Orlando | Orlando | Florida | 32803 | Not yet recruiting |
| Treasure Valley Medical Research | Boise | Idaho | 83706 | Recruiting |
| Grand Teton Research Group | Idaho Falls | Idaho | 83404 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Not yet recruiting |
| Rush University Medical Center | Chicago | Illinois | 60612 | Not yet recruiting |
| Midwest Digestive Health & Nutrition | Des Plaines | Illinois | 60016 | Recruiting |
| Springfield Clinic - First | Springfield | Illinois | 62702 | Recruiting |
| Gastroenterology Health Partners | New Albany | Indiana | 47150 | Recruiting |
| Gastroenterology Health Partners | Louisville | Kentucky | 40218 | Recruiting |
| GI Alliance - Gastro Group and Endocenter - Mandeville | Mandeville | Louisiana | 70471 | Recruiting |
| Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center | Wyoming | Michigan | 49519 | Recruiting |
| Mayo Clinic in Rochester, Minnesota | Rochester | Minnesota | 55905 | Not yet recruiting |
| KAD Clinical Research | St Louis | Missouri | 63123 | Recruiting |
| Specialists in Gastroenterology | St Louis | Missouri | 63141 | Recruiting |
| Digestive Disease Specialists - Las Vegas - Crimson Canyon Drive | Las Vegas | Nevada | 89128 | Recruiting |
| Virtua Health & Wellness Center - Moorestown | Moorestown | New Jersey | 08057 | Not yet recruiting |
| Saint Peter's University Hospital | New Brunswick | New Jersey | 08901 | Recruiting |
| Stony Brook University | Stony Brook | New York | 11794 | Not yet recruiting |
| Carolina Digestive Diseases and Endoscopy Center | Greenville | North Carolina | 27834 | Recruiting |
| Wilmington Health, PLLC | Wilmington | North Carolina | 28401 | Recruiting |
| Ohio State University | Hilliard | Ohio | 43026 | Not yet recruiting |
| DSI Research, LLC d/b/a ObjectiveHealth Clinical Research - Springboro | Springboro | Ohio | 45066 | Recruiting |
| Gastro Intestinal Research Institute of Northern Ohio, LLC | Westlake | Ohio | 44145 | Recruiting |
| The Oregon Clinic | Portland | Oregon | 97220 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Not yet recruiting |
| Sanford USD Medical Center | Sioux Falls | South Dakota | 57105 | Recruiting |
| Skyline Gastroenterology of West Tennessee | Jackson | Tennessee | 38301 | Recruiting |
| GI Alliance - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| GI Alliance - Garland | Garland | Texas | 75044 | Recruiting |
| Integrity Advanced Therapeutics | Houston | Texas | 77090 | Recruiting |
| GI Alliance: Mansfield | Mansfield | Texas | 76063 | Recruiting |
| Southern Star Research Institute | San Antonio | Texas | 78229 | Recruiting |
| GI Alliance - San Marcos | San Marcos | Texas | 78666 | Recruiting |
| Tyler Research Institute | Tyler | Texas | 75701 | Recruiting |
| Eximia Research-VA, LLC | Norfolk | Virginia | 23502 | Recruiting |
| Swedish Medical Center | Seattle | Washington | 98104 | Not yet recruiting |
| Principle Research Solutions | Spokane | Washington | 99202 | Recruiting |
| Providence Sacred Heart Medical Center & Children's Hospital | Spokane | Washington | 99208 | Not yet recruiting |
| Washington Gastroenterology - Tacoma | Tacoma | Washington | 98405 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 206 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07415044, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07415044 live on ClinicalTrials.gov.