An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers
Public ClinicalTrials.gov record NCT07426757. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN OPEN-LABEL PHASE 1 STUDY TO EVALUATE PF-07994525 IN PARTICIPANTS WITH ADVANCED MALIGNANCIES
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an open-label, dose escalation and dose expansion study evaluating the safety, tolerability, Pharmacokinetic (PK), Pharmacodynamic (PD), and antitumor activity of PF-07994525 in participants with R/R MM. The study will consist of 2 parts: Part 1 (Dose Escalation) will consist of PF-07994525 dose escalation to assess the safety, tolerability, and preliminary antitumor activity in participants with R/R MM. In Part 2 (Dose expansion), PF-07994525 may be evaluated in additional participants with R/R MM to further assess safety, PK, PD, and preliminary anti-tumor activity.
Study identification
- NCT ID
- NCT07426757
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 120 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1, 2026 (Actual)
- Primary completion
- Jul 10, 2029 (Estimated)
- Completion
- Jul 10, 2030 (Estimated)
- Last update posted
- Oct 13, 2026
2026 – 2030
United States locations
- U.S. sites
- 24
- U.S. states
- 5
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | Recruiting |
| Presbyterian/St. Luke's Medical Center | Denver | Colorado | 80218 | Recruiting |
| Smilow Cancer Hospital - Yale New Haven Health | New Haven | Connecticut | 06510 | Recruiting |
| Yale-New Haven Hospital-Yale Cancer Center | New Haven | Connecticut | 06510 | Recruiting |
| Smilow Cancer Hospital Phase 1 Unit | New Haven | Connecticut | 06511 | Recruiting |
| Yale University - Smilow Cancer Hospital; C/O Thomas Ferencz, RPh, BCOP | New Haven | Connecticut | 06511 | Recruiting |
| Smilow Cancer Hospital - North Haven | North Haven | Connecticut | 06473 | Recruiting |
| Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center | Coral Gables | Florida | 33146 | Recruiting |
| Sylvester Comprehensive Cancer Center - Coral Springs | Coral Springs | Florida | 33065 | Recruiting |
| University of Miami Hospital and Clinics - Deerfield Beach | Deerfield Beach | Florida | 33442 | Recruiting |
| Sylvester Comprehensive Cancer Center- Doral | Doral | Florida | 33166 | Recruiting |
| Sylvester Comprehensive Cancer Center - Hollywood | Hollywood | Florida | 33021 | Recruiting |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | Recruiting |
| University of Miami Hospital and Clinics | Miami | Florida | 33136 | Recruiting |
| Sylvester Comprehensive Cancer Center- Kendall | Miami | Florida | 33176 | Recruiting |
| Sylvester Comprehensive Cancer Center - Sole Mia | North Miami | Florida | 33181 | Recruiting |
| Sylvester Comprehensive Cancer Center - Plantation | Plantation | Florida | 33324 | Recruiting |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | Recruiting |
| Emory University Hospital | Atlanta | Georgia | 30322 | Recruiting |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | Recruiting |
| Sarah Cannon Research Institute - Pharmacy | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Tristar BMT | Nashville | Tennessee | 37203 | Recruiting |
| TriStar Centennial Medical center | Nashville | Tennessee | 37203 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07426757, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07426757 live on ClinicalTrials.gov.