A Study to Assess the Effectiveness and Safety of IPN10200 in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
Public ClinicalTrials.gov record NCT07427797. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicentre, Double-blind, Randomised, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of a Single Dose of IPN10200 in the Improvement of Moderate to Severe Glabellar Lines in Adult Participants
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the effectiveness and safety of Corabotase (also known as IPN10200) compared to placebo in the improvement of the appearance of moderate to severe glabellar lines in adult participants. Glabellar lines are wrinkle-like lines that appear between the eyebrows and can become more noticeable with age or repeated facial expressions. They may affect a person's appearance and confidence. In this study, all participants will receive a single injection of either Corabotase or placebo (the study drug). There will be 3 periods in this study: * A screening period (up to 20 days) to assess whether the participant can take part, requiring at least 1 visit to the study centre. * A treatment period (Day 1) where all the eligible participants will receive a single injection of IPN10200 or placebo. * A follow-up period (52 weeks) where participants' health will be monitored, consisting of regular visits to the study centre and 1 telephone call visit. Participants will undergo health measurements and observation, including blood sampling, physical examinations, clinical evaluations and electrocardiograms (ECG: recording of the electrical activity of heart). They will also be asked to fill in questionnaires and keep a diary. Each participant will be in this study for up to 55 weeks. Participants may withdraw consent to participate at any time.
Study identification
- NCT ID
- NCT07427797
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 300 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 26, 2026
- Primary completion
- Dec 14, 2026
- Completion
- Jul 14, 2027
- Last update posted
- Jul 27, 2026
2026 – 2027
United States locations
- U.S. sites
- 17
- U.S. states
- 8
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Skin Wellness Dermatology - Homewood | Birmingham | Alabama | 35209 | Recruiting |
| Advanced Research Associates | Glendale | Arizona | 85308 | Recruiting |
| Avacare | Scottsdale | Arizona | 85260 | Not yet recruiting |
| Investigate MD, LLC | Scottsdale | Arizona | 85260 | Recruiting |
| Ablon Skin Institute and Research Center | Manhattan Beach | California | 90266 | Recruiting |
| Keith A. Marcus, MD Inc | Redondo Beach | California | 90277 | Recruiting |
| West Dermatology | San Diego | California | 92121 | Not yet recruiting |
| Ava T. Shamban, M.D., Inc. | Santa Monica | California | 90404 | Recruiting |
| Art of Skin MD | Solana Beach | California | 92075 | Recruiting |
| Pacific Clinical Innovations Inc. | Vista | California | 92083 | Recruiting |
| Skin Research Institute | Coral Gables | Florida | 33146 | Recruiting |
| ICON Dermatology and Aesthetics | Bethesda | Maryland | 20852 | Recruiting |
| Clinical Research Center of the Carolinas | Charleston | South Carolina | 29407 | Not yet recruiting |
| Westlake Dermatology & Cosmetic Surgery - Westlake | Austin | Texas | 78746-5059 | Recruiting |
| Dermatology and Laser Surgery Center | Houston | Texas | 77004 | Recruiting |
| Pflugerville Dermatology Clinical Research Center, Inc. d/b/a Austin Institute for Clinical Research | Pflugerville | Texas | 78660 | Recruiting |
| SkinDC | Arlington | Virginia | 22209 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07427797, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 27, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07427797 live on ClinicalTrials.gov.