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Recruiting Phase 3 Interventional

INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)

ClinicalTrials.gov ID: NCT07429266

Public ClinicalTrials.gov record NCT07429266. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:55 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized, Double-blind, Placebo-controlled Global Study of Sapablursen in Polycythemia Vera

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the efficacy and safety of sapablursen when added on to current standard of care (SOC) for Polycythemia Vera (PV) therapy. The study will be conducted in three sequential parts (Part 1a blinded treatment, Part 1b open-label treatment, \& Part 2 long-term extension). Participants may receive treatment for up to 156 weeks.

Study identification

NCT ID
NCT07429266
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Ono Pharmaceutical Co., Ltd.
Industry
Enrollment
250 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
May 25, 2026 (Actual)
Primary completion
Sep 2028 (Estimated)
Completion
Jan 2031 (Estimated)
Last update posted
Oct 21, 2026

2026 – 2031

United States locations

U.S. sites
12
U.S. states
9
U.S. cities
12
Facility City State ZIP Site status
UC Irvine Health - Chao Family Comprehensive Cancer Center Orange California 93868 Recruiting
Regis Clinical Research LLC. Miami Florida 33126 Recruiting
Florida Clinical Trials Group Plantation Florida 33322 Recruiting
Florida Clinical Trials Group Tamarac Florida 33321 Recruiting
Central Georgia Cancer Care Macon Georgia 31210 Recruiting
The Center for Cancer & Blood Disorders Bethesda Maryland 20817 Recruiting
The Cancer and Hematology Centers Grand Rapids Michigan 49503 Recruiting
Montefiore Medical Center The Bronx New York 10461 Recruiting
Gabrail Cancer Center Research Canton Ohio 44718 Recruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Columbus Ohio 43210 Recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 Recruiting
Hematology Oncology Associates of Fredericksburg Fredericksburg Virginia 22408 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07429266, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 21, 2026 · Synced Oct 21, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07429266 live on ClinicalTrials.gov.

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