A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
Public ClinicalTrials.gov record NCT07432958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2, Double-blind, Placebo-controlled Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
Study identification
- NCT ID
- NCT07432958
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Appello Pharmaceuticals, Inc.
- Industry
- Enrollment
- 150 participants
Conditions and interventions
Conditions
Interventions
- AP-472 Drug
- Placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 30 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 24, 2026
- Primary completion
- Sep 2, 2027
- Completion
- Jan 2, 2028
- Last update posted
- Jul 19, 2026
2026 – 2028
United States locations
- U.S. sites
- 30
- U.S. states
- 17
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arkansas for Medical Sciences (Site #208) | Little Rock | Arkansas | 72205-5551 | Not yet recruiting |
| Profound Research LLC (Site #222) | Carlsbad | California | 92011 | Recruiting |
| Collaborative Neuroscience Network - Los Alamitos- CenExel - PPDS (Site #217) | Los Alamitos | California | 90720-3108 | Recruiting |
| Keck Medicine of USC - USC Healthcare Center 2 (Site #221) | Los Angeles | California | 90033-5310 | Not yet recruiting |
| Parkinson's Research Centers of America (Site #218) | Palo Alto | California | 94301 | Recruiting |
| Rocky Mountain Clinical Research - CenExel - PPDS (Site #215) | Englewood | Colorado | 80113-2776 | Recruiting |
| Parkinson's Disease & Movement Disorders Center of Boca Raton (Site #227) | Boca Raton | Florida | 33486 | Recruiting |
| UM-UHealth at Boca Raton (Site #226) | Boca Raton | Florida | 33486 | Not yet recruiting |
| Velocity Clinical Research - Hallandale Beach (Site #228) | Hallandale | Florida | 33009 | Recruiting |
| University of Miami (Site #220) | Miami | Florida | 33136-1051 | Not yet recruiting |
| Neurology One (Site #205) | Orlando | Florida | 32825 | Recruiting |
| USF Parkinson's Disease and Movement Disorders Center (Site #206) | Tampa | Florida | 33613-4808 | Not yet recruiting |
| Augusta University Medical Center (Site #212) | Augusta | Georgia | 30912-0020 | Not yet recruiting |
| Josephson Wallack Munshower Neurology PC (Site #231) | Indianapolis | Indiana | 46256 | Not yet recruiting |
| The University of Kansas (KU) (Site #216) | Kansas City | Kansas | 66160 | Recruiting |
| Kentucky Neuroscience Institute (Site #213) | Lexington | Kentucky | 40536-0001 | Recruiting |
| Beth Israel Deaconess Medical Center (Site #211) | Boston | Massachusetts | 02215-5400 | Not yet recruiting |
| University of Michigan Health System (UMHS) (Site #202) | Ann Arbor | Michigan | 48109 | Not yet recruiting |
| Quest Research Institute - Alcanza - PPDS (Site #201) | Farmington Hills | Michigan | 48334-2973 | Recruiting |
| University of New Mexico Health Sciences Center (Site #225) | Albuquerque | New Mexico | 87106 | Recruiting |
| Joan and Sanford I. Weill Department of Medicine (Site #224) | New York | New York | 10021 | Not yet recruiting |
| Mount Sinai School of Medicine (Site #209) | New York | New York | 10029-6501 | Recruiting |
| Asheville Neurology Specialists, P.A. (Site #229) | Asheville | North Carolina | 28806 | Recruiting |
| Duke Neurological Disorders Clinic (Site #210) | Durham | North Carolina | 27705 | Not yet recruiting |
| Cleveland Clinic (Site #223) | Cleveland | Ohio | 44195-0001 | Not yet recruiting |
| The Ohio State University Wexner Medical Center (site #207) | Columbus | Ohio | 43210 | Recruiting |
| Vanderbilt University Medical Center (Site #204) | Nashville | Tennessee | 37232 | Not yet recruiting |
| Horizon Clinical Research: Gill Neuroscience - Houston (Site #232) | Cypress | Texas | 77429 | Not yet recruiting |
| Central Texas Neurology Consultants (Site #203) | Round Rock | Texas | 78681-3578 | Recruiting |
| EvergreenHealth (Site #219) | Kirkland | Washington | 98034-3013 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07432958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 19, 2026 · Synced Jul 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07432958 live on ClinicalTrials.gov.